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This paper aims at the study of the toxic mechanism of gelsemium total alkaloids ,i.e. their impacts on respiration,heart rate and blood pressure by 5 different concentrations(0.5,1.0,2.0,4.0,8.0 mg/kg).
为有效合理地利用钩吻，以家兔作为研究对象，每公斤体重分别静脉注射0.5，1.0，2.0，4.0，8.0mg的钩吻总碱，研究钩吻总碱对家兔的呼吸、心率和血压的影响，综合分析其毒理作用。
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The dose-response curve of histamine was shifted parallely to the right. pA2 was 9.34±0.61. The guinea-pigs were effectively reduced the rate of histamine induced death, decreased reaction extent of shock (P＜0.01) and prolonged latency period of shock (P＜0.05) by orally administered cetirizine ranged from 0.1, 0.2 and 0.4 mg.kg-1. The capillary permeability to intracutaneous injection of histamine was potently inhibited by orally administered cetirizine ranged from 0.0625 to 0.25 mg.kg-1 in mice, blue area obviously decreased (P＜0.01), and dose-response curve existed obviously. In which the effect of these dosage groups were superior to the group of chlorphenamine.
结果：西替利嗪3×10-8～3×10-7mol.L-1可剂量依赖性地对抗组胺引起的肠肌收缩，使组胺的量效曲线平行右移，pA2为9.34 ± s 0.61，西替利嗪0.1，0.2及0.4 mg.kg-1口服给药时，能明显减轻豚鼠静脉注射组胺所致休克反应的严重程度(P＜0.01)，并可延长豚鼠惊厥反应的潜伏期及降低死亡率(P＜0.05)，西替利嗪0.0625～0.25 mg.kg-1口服给药可显著对抗组胺引起的小鼠皮肤血管通透性的增高，使蓝染面积显著缩小(P＜0.01)，且存在明显的量效关系，3个剂量组的作用均优于氯苯那敏组。
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Intravoneous injection of 0.5mg/kgBW jingsongling cause the 60 minutesrelaxation of goat gastric motor.The effects of jingsongling on the gastric motor ofgoat is major of effects of α2 -adrenoceptor agonist,as well as that of α1 -adrenoceptor agonist,the effects of α1 -adrenoceptor agonist concentrate at thecardic and pylorus;the function of α2 -adrenoceptor exit widely at cardic,pylorus,rumen,reticulum,omasum and abomasum,the function at different part is not the same.The lowestdose of jingsonglinginhibiting the amplitude and frequency of the gastricmyoelectric is 0.01mg/kgBW;the influence of jingsonglingto the gastricmotility of goat is dose-dependent,and the amplitude regain after the frequency ofgastric myoelectriv wave.When the goat revived,the gastric motor function is notreach the level of the normal;the major reason ofjingsongling cause the goat gastricrelaxation is the amplitude renew slowly.The intravoneous injection ofjingsonglingfirst,after 5 minutes,intravoneous injection the antagonist,the effect of prazosin and idazoxan mixed is best,which can fast reversal of theinhibition of jingsongling on the gastric motor of goat,the effects of idazoxan isgood,and the prazosin block the effection of jingsongling is better than that ofxylazine,especially at cardia and pylorus.When intravoneous injection of0.5mg/kgBW idazoxan and/or prazosin only,the amplitude of gastric myoelectric ingoat increases at a certain degree,but the frequency is not changed.
静脉注射0.5mk/kgBW的静松灵引起山羊胃蠕动弛缓长达60分钟；静脉注射0.5mg/kgBW的静松灵对山羊胃蠕动机能的影响是以α2肾上腺素受体作用为主的，兼有α1肾上腺素受体的作用，而且静松灵的α1肾上腺素受体的作用主要集中在幽门和贲门；α2肾上腺素受体的作用广泛存在于贲门、瘤胃、网胃、瓣胃、皱胃和幽门中，不同部位间有功能上的差异；静注0.01mg/kgBW的静松灵是对山羊的贲门、瘤胃、网胃、瓣胃、皱胃和幽门的肌电波频率和振幅均产生影响的最低剂量；静注一定剂量的静松灵对山羊胃蠕动的抑制作用与剂量呈相关性；而且山羊胃肌电波振幅的恢复比肌电波频率的恢复慢；苏醒时山羊的胃蠕动机能尚未恢复到正常状态；静松灵引起山羊胃弛缓的主要原因是由于胃肌电波的振幅恢复慢；静注0.5mg/kgBW的静松灵，5分钟后静注0.5mg/kgBW的拮抗剂时，咪唑克生+哌唑嗪的作用最好，能迅速地逆转静松灵对山羊胃蠕动的抑制作用，咪唑克生也有很强的拮抗作用，而哌唑嗪对静松灵的拮抗效果好于对隆朋的拮抗；单独静注0.5mg/kgBW的咪唑克生和/或哌唑嗪时，山羊的瘤胃、网胃、瓣胃、皱胃、贲门和幽门的肌电波振幅有一定程度的增强，而肌电波频率未见变化。
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Objective To observe the effect of dexamethasone iv on the decrease of epidural morphine related postoperative nausea and vomiting.
目的 观察静脉注射地塞米松对减少手术后与硬膜外吗啡镇痛有关的恶心呕吐发生率的作用。
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All patients we re randomly divided into four groups.Mannitol group,in which patients were trea ted only with mannitol .Permutation group in which patient's were treated with mannitol f ollowed cerebrospinal fluid permutation.
将患者随机分为4组治疗：单独应用甘露醇治疗头痛及在甘露醇应用的基础上行脑脊液置换、地塞米松鞘内注射和静脉注射，对比观察4个组的止痛效果。
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Diazepam can cause significant discomfort on intravenous infusion, and if patients are followed for a number of days after injection it has been shown to cause thrombophlebitis in a significant number of cases.
地西泮静脉注射时有显著的不适感，如果连续几天注射，有很多病例产生了静脉血栓。
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Objective:To assess the effect of a course of intravenous dexamethasone on pain after tonsillectomy.
目的：评价地塞米松静脉注射对减轻扁桃体切除术后疼痛的效果。
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Antiophidic serum was given by intravenous injection according to the skin test with certain venin serum, at the same time given intravenous drip of dexamethasone 20-30mg/d and procaine 10-30ml (0.25-0.5%) by circle block therapy near the area of swelling and numbness of snakebite.
根据不同种类毒蛇的咬伤，选用相对应的蛇毒血清皮试，阴性后直接静脉注射，同时静脉滴注地塞米松20～30mg/d，给予普鲁卡因0.25～0.5%10～30ml于受伤肢体肿胀或麻木部位近心端做环状封闭。
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The colon temperatures were measured by a thermistor and the cytosolic free calcium concentration ([Ca2+]i) in dissociated brain cells was measured by Fura 2-AM. The results demonstrated that the pyretic action of egtazic acid (0.6 μmol, icv) was markedly inhibited by DEX (5 mg/kg,iv), but DEX (60-120 μmol/L) did′t affect [Ca2+]i in dissociated hypothalamus cells. Actinomycin D, which interferes with gene transcription (3 nmol, icv), completely abolished the antipyretic action of DEX on egtazic acid-induced fever.
结果发现：脑室灌注乙二醇双(2-氨基乙醚)四乙酸(0.6 nmol)引起家兔结肠温度明显升高，静脉注射地塞米松(5 mg/kg)显著抑制家兔乙二醇双(2-氨基乙醚)四乙酸性发热，地塞米松(60-120 μmol/L)并不影响下丘脑细胞内[Ca2+]i，而事先脑室灌注抑制基因转录的放线菌素D(3 nmol)则完全取消了地塞米松对乙二醇双(2-氨基乙醚)四乙酸性发热的解热作用。
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Methods Diazepam and sodium valproate were continuously infused to patients by infusion pump. Meanwhile, CRRT was used to eliminate tetramethylene disulfotetramine.
采用静脉微量注射泵静脉注射地西浮和德巴金，同时应用CRRT治疗重度毒鼠强中毒。
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Powders：药丸 粉末 液体 静脉注射液体
- Stop it. - Neither do I. But it's a lo... | Pills, powders, liquids, I. V. Fluids.|药丸 粉末 液体 静脉注射液体 | Somewhere at a party, in his coffee, up his nose, in his ear, this kid had some.|某个地...
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liquids：药丸 粉末 液体 静脉注射液体
- Stop it. - Neither do I. But it's a lo... | Pills, powders, liquids, I. V. Fluids.|药丸 粉末 液体 静脉注射液体 | Somewhere at a party, in his coffee, up his nose, in his ear, this kid had some.|某个地...