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Through the multiple stepwise regression analysis, the duration of the disease and serum GH level were the main influencing factors of acromegalic cardiomyopathy. 2 Ejection fraction and fractional shortening, were decreased, compared to control group, they still remained in normal range. 3 Isovolumic relaxation time and E wave descending time, were delayed apparently compared to control group, indicating the damage of cardiac relaxation. 4 Subgroup analysis in acromegalic: The comparison between patients with diabetes mellitus and impaired glucose tolerance and patients without DM/IGT showed that there was no significant difference in terms of the parameters in the two groups, in spite of an mild increase of IVST in the former group.
经多元逐步回归分析，病程和血清生长激素浓度为心肌肥厚的主要影响因素。2实验组射血分数和左心室短轴缩短率虽较对照组低，但仍在正常范围。3实验组左心室等容舒张时间和二尖瓣减速时间较对照组明显延长。4实验组中继发糖尿病／糖耐量减低组与非DM/IGT组进行比较，前者仅室间隔有较明显增厚，其余各项参数2组间差异均无统计学意义。
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The typical apoptotic morphological features appeared in MUTZ1 cells treated with 4 mmol/L VPA for 72 hours. Pyknosis of cells and nuclei, disintegration of nuclear chromatin and apoptotic body could be observed by light microscopy. Aggregation and margination of nuclear chromatin, concentration of plasm, increment of density and chromatin mass of irregular size could be observed by transmission electronmicroscope. The flow cytometric analysis indicated that the VPA could induce cell apoptosis, apoptosis rate increased in dosedependent manner, ratio of cells at G0/G1 phase increased and ratio of cells at S phase decreased in dosedependent manner, the cells were arrested at G0/G1 phase.
结果显示： VPA对MUTZ1细胞的生长抑制作用呈现时间和剂量依赖性；经4 mmol/L VPA处理MUTZ1细胞72小时后，细胞呈现典型的凋亡形态特征，光学显微镜下可见凋亡细胞胞体固缩、核固缩、核碎裂及凋亡小体；透射电子显微镜下可见凋亡细胞核染色质边集、胞浆浓缩、密度增加，胞浆内大小不规则的染色质团块；流式细胞术结果表明，细胞凋亡率随着VPA浓度的增加而逐步增高，G0/G1期细胞比例随着VPA浓度的增加而逐渐增多，S期细胞比例逐渐减低，细胞被阻滞在G0/G1期。
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The typical apoptotic morphological features appeared in MUTZ-1 cells treated with 4mmol/L VPA for 72hours. Pyknosis of cells and nuclei, disintegration of nuclear chromatin and apoptotic body could be observed by light microscopy. Aggregation and margination of nuclear chromatin, concentration of plasm, increment of density and chromatin mass of irregular size could be observed by transmission electronmicroscope. The flow cytometric analysis indicated that the VPA could induce cell apoptosis, apoptosis rate increased in dose-dependent manner, ratio of cells at G0/G1 phase increased and ratio of cells at S phase decreased in dose-dependent manner, the cells were arrested at G0/G1 phase.
结果显示：VPA对MUTZ-1细胞的生长抑制作用呈现时间和剂量依赖性；经4mmol/LVPA处理MUTZ-1细胞72小时后，细胞呈现典型的凋亡形态特征，光学显微镜下可见凋亡细胞胞体固缩、核固缩、核碎裂及凋亡小体；透射电子显微镜下可见凋亡细胞核染色质边集、胞浆浓缩、密度增加，胞装内大小不规则的染色质团块；流式细胞术结果表明，细胞凋亡率随着VPA浓度的增加而逐步增高，G0/G1期细胞比例随着VPA浓度的增加而逐渐增多，S期细胞比例逐渐减低，细胞被阻滞在G0/G1期。
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de-escalate：逐步降级
de-emphasize 不再强调 | de-escalate 逐步降级 | de-escalation 减低战争范围