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Results: The PCNA mean labelling index was 48.84％± 13.63％, and the apoptotic labelling index was12.26‰± 5.20‰. The Kaplan-Meier survival curves showed that the postoperative survival time of the patient was shorter when the tumor infiltrated to the adventitia of esophagus,with lymph node metastasis, without keratinization, PI ≥ 40％ or AI＜10‰. Using forward multivariate Cox regression analysis, only the parameters of pN category and PI could be verified as independent prognostic factors.
结果：36例手术切除的食管鳞癌组织平均PCNA表达指数(PCNAlabellingindex，PI)为48.84％±13.63％，细胞凋亡指数(apoptosisindex，AI)为12.26‰±5.20‰；PI升高与患者年龄小、分化程度低、有淋巴结转移和肿瘤进行性浸润呈正相关，而AI升高与分化程度高、角化明显呈正相关；绘制Kaplan－Meier生存曲线，发现病变侵及食管外膜、有淋巴结转移、无角化、PI≥40％或AI＜10‰的患者术后生存率明显降低；COX比例风险模型分析，发现只有淋巴结转移和PI是影响预后的独立因素。
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The character of X|ray shows that located pleural incrassation, and find malignant tumor cells in thorax water, and have the character of double differentiation in pathologic section.
结果 80%病人临床上有胸痛且进行性加重，并有胸腔积液。X光有局限性胸膜增厚，胸水显示出现恶性瘤细胞，病理切片有双向分化特点。
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Both Fas and NO can lead chondrocyte apoptosis respectively and cause articular cartilage destruction. IGF-Ⅰ, TGF-β, bFGF, BMP and other growth factors are polypeptide agents that can influence cell activity by signal convection. They can accelerate chondrocyte proliferation and proteoglycan synthesis, play the local regulation action on formation and plerosis of bone and cartilage tissue by autocrine or paracrine. They have the ability to induce cartilage formation. Some investigations showed that growth factors can influence chondrocyte metabolism, synthesis of specific Ⅱ type collagen and proteoglycan by co-operation and inhibition. 1. 3 Situation of OA therapeutics The therapeutic methods of OA mainly comprised non-drug treatment, drug treatment, operation treatment, tissue and genetic engineering, et al. Drug treatment is the chief method among them.
若其活性发生改变，则将导致关节软骨基质成分的丢失和进行性破坏；软骨细胞凋亡与OA的发病密切相关，Fas与NO可各自独立介导软骨细胞凋亡，造成关节软骨破坏；IGF-Ⅰ、TGF-β、bFGF、BMP等生长因子是一组通过细胞间信号传递影响细胞活动的多肽因子，具有促进细胞生长、增殖与合成等作用，可通过自分泌或旁分泌方式对骨和软骨的形成和修复起局部调节作用，可促进软骨细胞增殖、分化与蛋白多糖的合成，具有较强的诱导软骨形成的能力，研究表明多种生长因子相互促进、相互抑制，以协同或拮抗方式影响软骨细胞代谢，影响软骨细胞特异性Ⅱ型胶原和蛋白多糖的合成分泌。
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lymphoma：淋巴瘤
淋巴瘤(lymphoma)是起源于淋巴结和淋巴组织的免疫系统恶性肿瘤,其发生大多与免疫应答过程中淋巴细胞增殖分化产生的某种免疫细胞恶变有关,以无痛性进行性的淋巴结肿大和局部肿块为其特征性的临床表现,并可有相应器官压迫症状.