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The cytotoxicity of these compounds were valuated by MTT and SRB methods using three cancer cell lines: HL-60, A-549, P-388. Cyclo-shikonin, and cyclo-alkannin have high cytotoxicity against HL-60.The chiral center of side chain has no effect on their activity. 2- 1-(Acetyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (105) has strong inhibition effect on P-388 cells. 2- 1-(isooctyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (108) and 2- 1-(2-furoyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (112) have high inhibition on A-549.Shikonin (1), alkannin (2), and their derivatives have the structural features of a planar chromophores and short side chain. We examined the ability to inhibit the telomerase.
抗肿瘤活性初步筛选测试采用小鼠白血病P-388肿瘤细胞和人肺癌A-549肿瘤细胞进行,结果表明侧链羟基的手性对抗肿瘤活性无明显影响;有数个化合物具有很好的体外抑制活性,特别是化合物2-(1-异辛酰氧基-4-甲基-3-戊烯基)-5,8-二羟基-1,4-萘醌(108)和2-[1-(2-呋喃甲酰氧基)-4-甲基-3-戊烯基]-5,8-二羟基-1,4-萘醌(112)体外显示对人肺癌A-549肿瘤细胞有强效;2-(1-乙酰氧基-4-甲基-3-戊烯基)-5,8-二羟基-1,4-萘醌(105)对小鼠白血病P-388肿瘤细胞有强效;环紫草素和环异紫草素对人白血病HL-60细胞有强烈抑制作用。
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Amino(9-deoxy)epicinchonine was synthesized from cinchonine through the Mitsunobu reaction and was treated with p-toluenesulfonyl chloride,4-chlorobenzene sulfonyl chloride respectively to give two new chiral sulfonamide s.
以辛可宁为原料,经Mitsunobu反应合成了9-氨基(9-脱氧)表辛可宁,然后分别与对甲苯磺酰氯、对氯苯磺酰氯反应,合成了两个新手性磺酰胺,其结构经红外光谱和核磁共振确证。
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Amino(9-deoxy)epi cinchonine was synthesized from cinchonine through the Mitsunobu reaction and was treated with p-toluenesulfonyl chloride,4-chlorobenzene sulfonyl chloride respectively to give two new chiral sulfonamides.
以辛可宁为原料,经Mitsunobu反应合成了9-氨基(9-脱氧)表辛可宁,然后分别与对甲苯磺酰氯、对氯苯磺酰氯反应,合成了两个新手性磺酰胺,其结构经红外光谱和核磁共振确证。
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Water,Hydrogenated Polyisobutene,Cyclohexasiloxane,Glycerin,Alcohol Denat,Cetearyl Alcohol,PEG-20,Petrolatum,C13-14 Isoparaffin,Zea Mays Oil,Tocopheryl Acetate,Hydroxypropyl Tetrahydropyrantriol,Hydrolyzed Soy Protein,CI 14700/Red 4,Phenoxyethanol,Adenosine,PEG-100 Stearate,Ethylparaben,Triethanolamine,Polyacrylamide,Malus Domestica Stem Cell Culture,CI 19140/Yellow 5,Dimethyl Isosorbide,Dimethicone,Dimethiconol,Limonene,Xanthan Gum,Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate,Linalool,2-Oleamido-1,3-Octadecanediol,Capryloyl Salicylic Acid,Acrylates/C10-30 Alkyl Acrylate Crosspolymer,Passiflora Edulis Seed Oil,Disodium EDTA,Castanea Sativa Seed Extract,Butyrospermum Parkii· Cetyl Alcohol,Butylene Glycol,Octyldodecanol,Cetearyl Glucoside,Methylparaben,Citronellol,Prunus Armeniaca Kernel Oil,Laureth-7,Coumarin,Oryza Sativa Bran Oil,Glyceryl Stearate,Fragrance
水,甘油,氢化聚异丁烯,液体石蜡/矿油,丁二醇,环己硅氧烷,鲸蜡醇,甘油硬脂酸酯,棕榈油,玉米胚芽油,PEG-100硬脂酸酯,白蜂蜡/蜂蜡,肉豆蔻醇肉豆蔻酸酯,石蜡,香精,腺苷,苧烯,山梨醇,CI 14700,CI 19140,稻糠油,杏仁油,EDTA二钠,羟丙基四氢吡喃三醇,苯氧乙醇,聚乙二醇-14M,异十六烷,氢氧化钠,辛基十二醇,季戊四醇四(双-t-丁基羟基氢化肉桂酸)酯,山梨坦三硬脂酸酯,水解大豆蛋白,卡波姆,鸡蛋果籽油,苹果果实提取物,欧洲栗籽提取物,异山梨醇酐二甲醚,聚山梨醇酯-80,辛酰水杨酸,2-油酰胺基-1,3-十八烷二醇,氯苯甘醚,麦芽糖醇,香豆素,黄原胶,微晶蜡,丙烯酰胺/丙烯酰基二甲基牛磺酸钠共聚物,丙二醇,芳樟醇,香茅醇,玉米油,羟苯丙酯,羟苯甲酯
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Result The three strains all produced the AHL signal molecules; the strains FML05-land FML05-2 produced two types of AHLs at least and the N-3-oxo-octanoyl-homoserine lactone was the predominant signal molecules. The production of siderophore and proteinase in FML05-2 were reduced by co-incubation with AHL degrader strain.
结果]3株菌均产生AHLs信号分子;菌株FML05-1、FML05-2至少产生两种AHLs分子,二者所产生的主要信号分子是N-3-氧代-辛酰基-高丝氨酸内酯(N-3-oxo-C8-HSL);FML05-2与降解AHLs的菌株共同培养,发现嗜铁素的产量与蛋白酶活性明显下降。
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This experiment adopted lipoic amido dehydrogenase histochemistry method and image pattern analysis technique to investigate the relationship between nitric oxide synthase neurons and activity of NOS and auditory threshold, and to explore the possible role of NOS neurone in cochlear nuclei of guinea pigs after exposed to white noise.
采用硫辛酰胺脱氢酶组织化学方法及图象分析技术,研究白噪声暴露后豚鼠耳蜗核一氧化氮合酶神经元及NOS活性的变化与听阈的关系,探讨豚鼠耳蜗核NOS神经元在白噪声损伤过程中可能的作用。
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This experiment adopted lipoic amido dehydrogenase histochemistry method and image pattern analysis technique to investigate the relationship between nitric oxide synthase neurons and activity of NOS and auditory threshold, and to explore the possible role of NOS neurone in cochlear nuclei of guinea pigs after exposed to white noise.
提要 采用硫辛酰胺脱氢酶组织化学方法及图象分析技术,研究白噪声暴露后豚鼠耳蜗核一氧化氮合酶神经元及NOS活性的变化与听阈的关系,探讨豚鼠耳蜗核NOS神经元在白噪声损伤过程中可能的作用。
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1-phenyl-3-methyl-4-caprylpyrazolone-5 was synthesized from 1-phenyl-3-methyl-pyrazolone-5 and caprylyl chloride, and some extraction parameters were investigated such as the acidity, the concentration of Sr, the time of the extraction and the thinners.
通过1-苯基-3-甲基-吡唑啉酮-5与辛酰氯合成萃取剂1-苯基-3-甲基-4-辛酰基吡唑啉酮-5,并对其萃取Sr的影响因素,如酸度、Sr浓度、萃取时间和稀释剂等进行研究。
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Dibutyltin maleate,dioctyltin maleate,N-phenyl maleimide, N-(p-chlorophenyl) maleimide,N-(p-nitrophenyl) maleimide with unsaturated groups were synthesized using dibutyltin oxide,dioctyltin oxide,maleic anhydride, aniline,p-chloroaniline,p-nitroaniline as raw materials,respectively.Then dibutyltin male,ate/styrene bipolymer,dibutyltin maleate/styrene/methyl acrylate terpolymer,dibutyltin maleate/styrene/N-phenyl maleimide terpolymer ,dibutyltin maleate/styrene/N-(p-chlorophenyl) maleimide terpolymer ,dibutyltin maleate/styrene/N-(p-nitrophenyl) maleimide terpolymer ,dioctyltin maleate/styrene biopolymer,dioctyltin maleate/styrene/methyl acrylate terpolymer,dioctyltin maleate/styrene/ N-phenyl maleimide terpolymer,dioctyltin maleate/styrene/ N-(p-ehlorophenyl) maleimide terpolymer[P(DOTM/St/NC1PMI)],dioctyltin maleate/styrene/N-(p-nitrophenyl) maleimide terpolymerwere synthesized using DBTO,DOTO,PMI,N-p-ClPMI,N-p-NOPMI,styrene and methyl acrylate as monomers,respectively.
再以DBTO,DOTO,PMI,N-p-ClPMI,N-p-NOPMI,苯乙烯,丙烯酸甲酯等为单体,合成了马来酸二丁基锡/苯乙烯二元共聚物{P},马来酸二丁基锡/苯乙烯/丙烯酸甲酯三元共聚物{P},马来酸二丁基锡/苯乙烯/N-苯基马来酰亚胺三元共聚物{P(DBTM/St/NPMI)},马来酸二丁基锡/苯乙烯/N-对氯苯基马来酰亚胺三元共聚物{P(DBTM/St/NClPMI)},马来酸二丁基锡/苯乙烯/N-对硝基苯基马来酰亚胺三元共聚物{P(DBTM/St/NNOPMI)},马来酸二辛基锡/苯乙烯二元共聚物{P},马来酸二辛基锡/苯乙烯/丙烯酸甲酯三元共聚物{P},马来酸二辛基锡/苯乙烯/N-苯基马来酰亚胺三元共聚物{P(DOTM/St/NPMI)},马来酸二辛基锡/苯乙烯/N-对氯苯基马来酰亚胺三元共聚物{P(DOTM/St/NClPMI)},马来酸二辛基锡/苯乙烯/N-对硝基苯基马来酰亚胺三元共聚物{P(DOTM/St/NNOPMI)}。
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The contact angles of water and hexadecane on the resulting ultra thin film were measured so as to investigate the hydrophobic hydrophilic properties of the film.
结果表明:所制备的自组装膜的表面自由能很低,具有很好的疏水-疏油性,其对水的接触角高达 1 1 0°;二甲基-γ-全氟辛酰氧丙基硅烷组装膜可以降低基片的摩擦系数,而且在较低负荷下具有很好的耐磨性
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BOP:邻苯二甲酰丁辛酯
、邻苯二甲酰丁辛酯(BOP)行业下游发展状况分析三、邻苯二甲酰丁辛酯(BOP)行业下游对邻苯二甲酰丁辛酯(BOP)行业影响力分析第十二章 邻苯二甲酰丁辛酯(BOP)重点企业发展分析第十三章 邻苯二甲酰丁辛酯(BOP)行业投资策略分析第
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capryl:癸酰
calco-钙 | capryl-癸酰 | capryloyl-辛酰
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capryl:癸酰(基);辛基;辛酰(基)
calcium caprylate辛酸钙 | capryl癸酰(基);辛基;辛酰(基) | capryl alcohol辛醇
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caprylyl:辛酰
capryloyl-辛酰 | caprylyl-辛酰 | cef-头孢(头孢菌素族抗生素词首)
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caprylyl chloride:辛酰氯;氯化辛酰
辛腈 caprylic nitrile; caprylonitrile | 辛酰氯;氯化辛酰 caprylyl chloride | 辣椒碱 capsaicin
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caprylyl chloride:辛酰氯
capryloyl | 辛酰 | caprylyl chloride | 辛酰氯 | capsa | (古罗马图书馆中的)圆筒形书帙
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caprylyl; capryloyl:辛酰基
己酰基 caproyl | 辛酰基 caprylyl; capryloyl | 脲基 carbamido; ureido
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caprylyl acetate:醋酸正辛酯
caprylhydroxamic acid 辛酰氧肟酸 | caprylyl acetate 醋酸正辛酯 | CAPS, crew activity planning system 乗員活動計画システム
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octylene:伸辛基
辛酰基 octanoyl | 伸辛基 octylene | 庚酰基 oenanthyl; oenanthoyl; heptanoyl
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CAPRYLOYL GLYCIN:辛酰甘氨酸
PARFUM香料 | CAPRYLOYL GLYCIN辛酰甘氨酸 | CITRIC ACID柠檬酸