- 更多网络例句与血胆脂醇过多相关的网络例句 [注:此内容来源于网络,仅供参考]
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Bicyclic compounds containing a phenyl or pyridyl ring fused to a cycloalkyl or heterocyclic ring, to which is attached a 5-membered heterocyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
本发明涉及含有连接在5元杂环上的稠合至环烷基或者杂环的苯基或者吡啶基环的二环化合物,包括其药学上可接受的盐和前药,它们是G蛋白偶联受体40(GPR40)激动剂并且可以用作治疗性化合物,特别是在2型糖尿病和与这些疾病相关的症状中用作治疗性化合物,这些症状包括肥胖病和脂质疾病,比如混合或者糖尿病型血脂异常症、血脂质过多、高胆甾醇血和高甘油三酯血症。