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At the end of treatment ,the differences in the behavior science were observed ; the change of the nasal mucosa secretion were inspected cross-reference after build model; IL-2,IL-4mRNA in the spleen were used to do revers transcriptive polymerase chain reaction.
用卵清蛋白致敏大鼠制成变应性鼻炎动物模型，辛芷鼻敏胶囊及阳性对照组药物鼻炎康灌胃给药，观察其行为学差异，造模前后分别取鼻粘膜分泌物涂片检查，用逆转录—多聚酶链反应对大鼠脾脏IL-2、IL-4mRNA进行半定量检测。
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Day puppies were inoculated by abdominal cavity and nasal cavity with CDV,canine distemper patho-sample of duplicating meet with success and through differentdrug of treatment, specific antibody, dexamethasone, causing death by letting. Theresults of pathohistology observation on 14 PID: Control group, the hearts showedcardiac muscle hemorrhage and necrosis, the livers showed a large area of hepatictissue hyperemia, hemorrhage and necrosis, the spleens showed the quantity oflymphocyte grow downwards, the blood vessels of lung congested, congestion andhaemorrhage were serous fluid exudation, the kidneys showed heavy haemorrhageand hyperemia, the cerebrum showed the number of microglial cells of cerebrumincreased.
通过特异性抗体和地塞米松、特异性抗体、地塞米松三种不同的方法治疗后，放血致死，取材作病理切片，观察各组病理组织学变化，结果为：感染后14d阳性对照组的心脏表现为心肌出血、坏死；肝脏表现为肝组织大面积充血、出血坏死；脾脏表现淋巴细胞数量大量减少；肺脏表现为肺泡结构破坏，有坏死灶；肾脏表现为弥漫性的充血出血；大脑表现为胶质细胞增多。
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RESULTS:The SP and VIP content was evidently reduced in the treatment group compared to the model group; whole blood viscosity of blood rheology index, fibrinogen viscosity and packed cell volume were reduced in the treatment group as compared to the model group, which could evidently inhibit auricular swelling in mice and arthroncus in rats, raise the percentage of pain threshold, phagocytic index and rate of celiac macrophage and effect the spleen, the peripheral immune organ in mice.
结果：治疗组SP、VIP较模型组明显降低；血液流变学指标全血粘度、纤维蛋白粘度、红细胞压积测定，治疗组较模型组降低；能明显抑制小鼠耳廓肿胀和大鼠关节肿胀；提高小鼠痛阈百分率；提高小鼠腹腔巨噬细胞的吞噬指数和吞噬率；对外周免疫器官脾脏有明显影响。
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Staining and observing shows that the most pathological changes were interstitial pneumonia and hemorrhagic pneumonia, typical nonsuppurative encephalitis, and neurogangliitis et al. The lymphoid tissue was necrosis, and the amount of lymphocytes was reduced. The pathological changes of the positive cells, especially the epithelial cells were swell, denaturization and hyperplasy to the extent.
H.E。染色观察显示，病理组织学变化主要表现为间质性肺炎和出血性肺炎、典型的非化脓性脑炎、神经节炎等；淋巴结、扁桃体和脾脏等组织内淋巴细胞坏死、数目减少；有阳性反应的细胞，特别是阳性上皮细胞呈现不同程度的肿胀、变性、增生等病理变化。
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Methods:①Pharmacodynamics observed the effects of The root and leaf of Panicled Fameflower on swimming time of mouse, and physiological function, IL-2 IgA IgM IgG C3 C4 of rat of asthenia of the spleen, and The leaf of Panicled Fameflower on determinating mininal inhibitory concentration, swelling of mouse ear, capillary vein permeability of mouse skin, granuloma in rat.
①药效学实验：观察土人参根、叶对小鼠游泳时间的影响，以及对&脾虚&大鼠脾脏生理功能，细胞因子IL-2、IgA、IgM、IgG、C3、C4的影响，验证土人参根、叶&健脾&功效；观察土人参叶体外抗菌实验，对二甲苯致小鼠耳廓肿胀的影响，对小鼠皮肤毛细血管通透性增高的影响，以及对大鼠棉球肉芽肿的影响，验证土人参叶&解毒消痈&功效。
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The dynamic changes of the number of T or B lymphocytes and the content of immunoglobulin G, IgM, IgA in peripheral blood, the number of CD〓, CD〓 lymphocyte subpopulation, T〓 cells and IgG, IgM, IgA antibody-producing cells, the ratios of CD〓 and CD〓 T cells in immune organs (thymus, bursa of Fabricius and spleen) and immune tissues (cecal tonsils and Harderian glands), the content of IgA, IgM, IgG in local fluid (tear, tracheal fluid, intestinal fluid and bile) of one-day chicks infected with chicken infectious anemia virus and CIAV-infected chicks immunized with Newcastle disease vaccine were determined respectively by immunohistochemistry, immunogold-silves and immunoenzyme staining in order to reveal mechanism of immunopathogenesis of chicks infected with CIAV and influence of immune responses of CIAV-infected chicks to ND vaccine.
中文题名雏鸡感染鸡传染性贫血病毒后免疫变化和对新城疫疫苗的应答及其免疫机理副题名外文题名 Immune changes of chicks infected with chicken infectious anemia virus and immune response and mechanism to Newcastle disease vaccine immunity 论文作者郑世民导师刘忠贵教授学科专业基础兽医学研究领域\研究方向学位级别博士学位授予单位东北农业大学学位授予日期2002 论文页码总数105页关键词鸡传染性贫血病雏鸡新城疫疫苗馆藏号BSLW /2003 /S858 /9 本项研究采用免疫组织化学、免疫胶体金及免疫酶方法，首次对CIAV感染1日龄雏鸡和CIAV感染雏鸡ND疫苗免疫及vNDV攻击后，其外周血液的T细胞、B细胞数量和IgG、IgM、IgA含量；中枢免疫器官胸腺和法氏囊，外周免疫器官脾脏及呼吸道和消化道局部粘膜免疫组织哈德尔腺和盲肠扁桃体的ANAE〓、CD4〓、CD〓T细胞、IgG、IgM、IgA抗体生成细胞数量和CD〓与CD〓T细胞比值以及泪液、气管液、肠液、胆汁的IgA、IgM、IgG含量的动态变化规律和CIAV感染对ND疫苗的免疫保护率等进行了全面系统地研究。
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Methods The suspension of human fetal hepatocytes was transplanted into the abdominal cavity, liver, speen and mesenterium respectively. Three months later, histological observation was performed.
将人胎肝细胞悬液分别移植至裸鼠的腹腔、肝脏、脾脏及肠系膜，3个月后进行移植部位的组织学观察。
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The findings of the newly identified goose paramyxovirus strain GPMV/HBexperimental infection were as follows: The challenge caused high morbidity and highmortality.The clinical signs included severe depression, decreased appetite or anorexia,white,yellow and green diarrhea, with neural symptoms;pathological changes showed thathaemorrhage and ulceration of intestine mucosa, necrosis of spleen and pancreas,andedema of liver and kidney, uratic deposition in kidney.Eosinophilic inclusion bodies werefound in the cytoplasm of pancreas and a large quantities of fiber protein were found inintestine. Lots of hemosidefin was found in some area of liver and kidney. A number ofT、B lymphocytes reduced sharply in spleen,lymph nodes in dead geese. Transmissionalelectron microscope showed that some cells had the morphological characteristics ofmitochondria swelling, morphological changes were condensation of nuclear chromatininto dense masses,followed by its marginating against the nuclear envelope, andespecially concentration of cytoplasm association with lots of lipid droplet.
人工感染雏鹅实验中，雏鹅临床表现为高发病率和高死亡率，食欲和饮水减少，拉白色、黄绿色稀粪，伴有神经症状；常规组织学观察，脾脏和胰腺肿大，有白色坏死斑点，肠道出血和坏死，肝脏肿大变性，肾脏肿大变性有尿酸盐沉着等；用特殊染色和组织化学方法首次对人工感染鹅副粘病毒的雏鹅的重要脏器进行研究，结果表明：胰腺中发现病毒包涵体，肠道中大量纤维素以及胶原纤维增生，肾脏、肺脏大量含铁血黄素沉着，免疫器官如脾脏和淋巴结中T、B淋巴细胞大量减少；电镜下多种细胞呈现线粒体水肿，多种实质细胞的染色质固缩，染色质边集，特别是细胞内容物如脂肪滴增多的病理变化特征。
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Methods 34cases of benign splenic space-occupying lesions were obtained and their clinical manifestation,image characteristics and curative effect were retrospectively analyzed.
回顾性 分析 34例脾脏良性占位性病变的临床表现、影像学特点和临床疗效。
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splenitis：脾炎
第七章 造血系统病理第一节脾 炎脾炎(splenitis),即脾脏的炎症.一,急性炎性脾肿急性炎性脾肿(acute inflammatory splenectasis)是指伴有脾脏明显肿大的急性脾炎.1,病理变化 (如图)(1),眼观变化(2),组织学变化2,结局二,
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Splenography; Description of spleen：脾脏论
Splenic tuberculosis 脾结核 | Splenography; Description of spleen 脾脏论 | Splenology 脾脏学
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splenology：脾脏学
splenokeratosis 脾硬化 | splenology 脾脏学 | splenolysin 脾溶素 溶脾素
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splenolysin：脾溶素 溶脾素
splenology 脾脏学 | splenolysin 脾溶素 溶脾素 | splenolysis 脾溶解 脾组织破坏
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splenolysis：脾溶解
splenology 脾脏学 | splenolysis 脾溶解 | splenolysis 脾组织破坏
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splenotyphoid：脾病性伤寒
Splenology 脾脏学 | Splenotyphoid 脾病性伤寒 | Splintered fracture 条碎骨折