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There were five rats in every group. And their fimbria/fornix was transected in order that AD models were made.
在脑立体定位仪上切断穹隆海马伞,建立模拟AD动物模型。
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Objective To observe the expression of nicotinic acetylcholine receptor in the brain's fimbria/fornix transected rats, the effect of ectogenic estrogen on it, and its relation with Alzhelmer's disease.
目的 以双侧穹隆海马伞切断制作阿尔茨海默病大鼠模型,观察脑内海马CA1区和皮层区烟碱型乙酰胆碱受体表达的变化,探讨与 AD相关的发病机制,并观察雌激素的干预作用。
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The bilateral fimbria-fornix of brain was transected in the fimbria/fornix transaction group.
在脑立体定位仪上,切断大鼠脑的双侧穹隆海马伞同时切除双侧卵巢,建立模拟AD的动物模型。
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It has not been reported that effects of agmatine on discharges of hippocampal and subfornical organ neurons.
有关胍丁胺对离体大鼠海马脑片CA1区锥体细胞层放电和离体大鼠穹隆下器神经元放电的影响,迄今未见报道。
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The cells expressing nAchR clearly decrease in the areas of CA1 and cortex of rats when their fimbria/fornix is transected, but the cell number increases significanly if ectogenic estrogen is added. The change in nAchR is closely relative with AD whose pathological course can be influenced by the intervention of estrogen.
穹隆海马伞切断组大鼠脑内海马CA1区、皮层区nAchR的阳性细胞显著减少,补充外源性雌激素治疗后,上述各脑区内的nAchR表达显著增加。nAchR的变化与AD的病理变化过程密切相关,补充雌激素可以干预这种病理过程。
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The cell suspensions were injected into the hippocampus of rat which had received unilateral transection of fimbria-fornix before one week. 5,7,14,30,60,90,150 and 180 days after grafting, the rats were perfused and postfixed, cut section. A series of every second and third sections were used for NOS enzyme histochemistry and Nissl histochemistry.
将大鼠14~16d胚胎的基底前脑移植到单侧穹隆海马伞切断的成年大鼠海马内,动物在移植后存活5、7、14、30、60、90、150和180d分别取脑,经NADPH-d法和尼氏染色观察。
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anencephalia:无脑畸形
1.无脑畸形 无脑畸形(anencephalia)是一种严重的DNT,为脑的全部或大部缺如,头颅的缺损从顶部开始,可延伸到其与枕骨大孔的任何部位,患儿因颅骨穹隆缺如造成面部特殊外貌,其前颅窝缩短和眼眶变浅,使眼球向前突出,下颌紧贴胸骨,口半张开,