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The course will start with an overview of the central and peripheral nervous systems, the development of their structure and major divisions. The major functional components of the CNS will then be reviewed individually. Topography, functional distribution of nerve cell bodies, ascending and descending tracts in the spinal cord. Brainstem organization and functional components, including cranial nerve nuclei, ascending / descending pathways, amine-containing cells, structure and information flow in the cerebellar and vestibular systems. Distribution of the cranial nerves, resolution of their skeletal and branchial arch components. Functional divisions of the Diencephalon and Telencephalon. The course will then continue with how these various CNS pieces and parts work together.
这门课将会从中枢和周边神经系统构造的发展和主要的分化点来概述,中枢神经系统的主要功能将会在复习中个别地说明:神经细胞体的断层以及功能性的分布、脊髓内上升和下降神经束的特征学和功能分布;脑干组织和功能要素,包括脑神经核、上升和下降神经束走向、含胺基酸脑激素细胞的分布、小脑和内耳前庭系统的构造和资讯传导流;颅神经的分布、骨弓和腮弓的演化;间脑和终脑的功能与分类;这门课将会探讨这些不同的中枢神经系统如何一起作用。
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The protein and phospholipid constituent in membrane of neurocyte in brain of chicken with encephalomalacia was separated and studied with the method of SDS-PAGE electrophoresis and the method of high performance-thin layer chromatography respectively The fluidity of neurocyte membrane of chicken with encephalomalacia was determined for the first time The content of Ca and trace elements were determined in chicken encephalomalacia systematically and the status of Fe ion in cerebellum was observed. The activity of enzymes that were relative to metabolism of energy and neuro-medium in brain were checked systematically with the method of enzyme-histochemistry. Pathological examination was carried out by microscopic and ultramicroscopic observation. The apoptosis of neurocyte in brain was checked.
在进行临床观察、定期剖杀并检测体内V〓含量、体重和脑重的基础上,重点研究了与神经损伤有关的以下几个方面的内容:系统地检测了体内自由基代谢和抗氧化系统功能的变化;首次采用SDS-PAGE电泳法分离并检测了雏鸡脑软化症神经细胞膜蛋白组分,并以高效薄层层析法检测神经细胞膜磷脂组分;测定了脑软化症雏鸡神经细胞膜的膜流动性;首次系统检测了脑软化症雏鸡体内钙及微量元素含量,并进行了小脑组织总铁离子状态观察;采用酶组织化学方法系统地观察了脑组织中与脑能量代谢和神经递质有关的酶的活性;对相关组织进行了病理组织学和超微结构观察;并对脑组织中神经细胞的凋亡进行了检测。
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The trial model with chicken encephalomalacia was set up by using the feed of low congtent of V〓 and supplying excessive unsaturated fatty acid in feed for studying the molecular mechanism of chicken encephalomalacia in the study. On the basis of observing the symptom and postmortem examination in clinic and determining the content of V〓, the bodyweight, the weight of cerebrum and cerebellum, the focus of the study was on follows which were relative to neuropathic injury. The concentration of free radical and the function of antioxidant defense system of chicken with encephalomalacia were determined systematically.
中文题名雏鸡脑软化症的分子机理副题名外文题名 The molecular mechanism of chicken encephalomalacia 论文作者王振勇导师石发庆教授学科专业临床兽医学研究领域\研究方向动物营养代谢病学位级别博士学位授予单位东北农业大学学位授予日期2002 论文页码总数110页关键词雏鸡脑软化鸡馆藏号BSLW /2003 /S858 /7 为了深入探讨雏鸡脑软化症发病的分子机理,本课题通过在采用低V〓饲料和添加过量UFA建立了雏鸡脑软化症实验模型。
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Methods The cognitive impairment rat model was induced by hypodermic D-galactose injection and half fat feeder (6 weeks), the Morris water maze was used to screen the model rats, which were divided randomly into 4 groups (12 rats in each group): the model group, the hydrochloricdonepezil group (0.4 mg/kg, weight, sic passim), the low-dose Huannao Yicong Fang group (7 g crude drug/kg), the high-dose Huannao Yicong Fang group (14 g crude drug/kg), they were treated respectively by intragastric administration. Besides, a control group of 12 rats was set up, they were given tales doses of distilled water. After 4 weeks, the behavior of the rats was detected, the contents of plasma P-selectin and PAI-1 were measured by ELISA, also the hemorrheology was measured.
采用皮下注射D-半乳糖及喂饲半高脂饲料(6周)的方法造成大鼠认知功能障碍,Morris水迷宫行为学测试确定模型成功的动物,随机分成四组(每组12只:模型对照组给予等量水,盐酸多奈哌齐组(0.4mg/kg,体质量,下同),还脑益聪方低剂量组(7g生药/kg),还脑益聪方高剂量组(14g生药/kg),同时灌胃给药,并设立正常对照组,给予等量水。4周后,对大鼠行为学检测,应用酶联免疫法检测大鼠血浆P-选择素及PAI-1含量和血液流变学各项指标。
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Topics include historical views of the brain; digital images of the brain; psychopharmacology; mental illness; neurotransmitters; and the culture of brain science.
主题包含有历史上对脑的观点,脑的数位影像;精神病药物学;心理疾病;神经传导物与脑科学的文化。
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Methods 104 patients with chronic cerebral circulation insufficiency were randomly divided into two groups.in basis of routine therapy, patients in treatment group (n=56) were treated by yangxue qingnao granules,4 g,three times a day; patients in control group (n=48) were treated by troxerutin, 3 pills a day.the course was 30 days in two groups.the indexes of hemorrheology and mca,aca,pca, va, ba and pi were observed before and after treatment.results there were significant differences between two groups in blood viscosity, plasma viscosity, mca,aca,pca,mca and pi after treatment (p.05).conclusion yangxue qingnao granules have definite effect on chronic cerebral circulation insufficiency, and decrease and hemorrheology in patients with ccci, relieve angiospasm and improve clinical symptoms.
将慢性脑供血不足患者104例随机分为2组。在常规治疗基础上治疗组56例加服养血清脑颗粒,每次4 g,每日3次口服。对照组48例在常规治疗基础上加服曲克芦丁,每次2片,每日3次口服。2组均30日为1个疗程。观察2组临床疗效,治疗前后血液流变学指标及大脑中动脉、大脑前动脉、大脑后动脉、左右椎动脉和基底动脉的搏动指数及阻力指数的变化。结果 2组治疗后全血黏度、血浆黏度,mca、aca、pca的pi及mca的ri及总有效率比较差异均有统计学意义(p<0.05)。结论养血清脑颗粒治疗慢性脑供血不足疗效确切,能降低ccci患者的血液黏稠度及血液流变学指标,增加脑供血,缓解血管痉挛,改善临床症状,改善脑供血不足。
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Results The negative correlations were found on the Glasgow Outcome Scoreto the items such as conscious state at admission,Glasgow Coma Score,psychiatric symptoms,hemiplegia,Babinski sign,abnomal degree of Electroencephalogram,focal lesions found by neuro-image investigation and mean peak flow velocityand pulsatility indexof basilar artery and vertebral arteries by transcranial Doppler ultrasonography investigation;The non-correlation was found on the Glasgow Outcome Score to theitems such as headache,febrile,epilepˉsia style,the involvement of cranial nerve,dystaxia,neck stiffness,Cerebrospinal fluid investigation and blood serum enzymology.
结果 入院时的意识状态、GCS、精神症状、偏瘫和/或偏身感觉障碍、巴彬斯基征以及脑电图异常程度、影像学所见的病灶范围、基底动脉和椎动脉的平均峰流速、脉动指数和Glasgow预后评分呈负相关;头痛、发热、癫痫类型、颅神经受累情况、共济运动、脑膜刺激征、脑脊液检查(含压力、蛋白定量、细胞数、HSV-PCR)以及血清酶学的变化和Glasgow预后评分之间无相关性。结论入院时的意识状态、GCS、精神症状、局灶性神经系统体征以及脑电图异常程度、影像学所见的病灶范围、后循环的血管痉挛程度和血流阻力等是影响病脑预后的主要因素。
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Results The negative correlations were found on the Glasgow Outcome Scoreto the items such as conscious state at admission,Glasgow Coma Score,psychiatric symptoms,hemiplegia,Babinski sign,abnomal degree of Electroencephalogram,focal lesions found by neuro-image investigation and mean peak flow velocityand pulsatility indexof basilar artery and vertebral arteries by transcranial Doppler ultrasonography investigation;The non-correlation was found on the Glasgow Outcome Score to theitems such as headache,febrile,epilepˉsia style,the involvement of cranial nerve,dystaxia,neck stiffness,Cerebrospinal fluid investigation and blood serum enzymology.
结果 入院时的意识状态、GCS、精神症状、偏瘫和/或偏身感觉障碍、巴彬斯基征以及脑电图异常程度、影像学所见的病灶范围、基底动脉和椎动脉的平均峰流速、脉动指数与Glasgow预后评分呈负相关;头痛、发热、癫痫类型、颅神经受累情况、共济运动、脑膜刺激征、脑脊液检查(含压力、蛋白定量、细胞数、HSV-PCR)以及血清酶学的变化与Glasgow预后评分之间无相关性。结论入院时的意识状态、GCS、精神症状、局灶性神经系统体征以及脑电图异常程度、影像学所见的病灶范围、后循环的血管痉挛程度和血流阻力等是影响病脑预后的主要因素。
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As a new diagnostic method, DTI technology should be a routine examination for cerebrovascular diseases.3 DTI sequence should be added when the patient with cerebral ischemia has been examinated by routine MRI and found LA or cerebral infarction on acute stage in doubt. DTI can find hyper-acute and acute cerebral infarction immediately in order to treat the illness in time.4 DTI technology can reflect the mini-alter of alba formation pericerebral infarction with non-invasion in vivo. It can also appraise the degree of cerebral infarction and anticipate the result.
应作为脑血管病影像学常规检查。3对于临床上有脑缺血表现的患者,其常规MRI检查仅发现有脑白质疏松或怀疑有急性期脑梗死,应该加做DTI序列以便及时发现并治疗疾病。4 DTI可在活体无创性的反映脑梗死灶周脑白质结构的微细改变及评估缺血性病变损伤的严重程度和预测脑梗死结果。
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Although classic neuroimaging features of RPLS with involvement of the posterior head regions are easily recognized, features that may generally be regarded as atypical were often present in our patients, such as significant anterior involvement, cortical lesions, recurrent RPLS episodes, foci of permanent injury, hemorrhage into lesions, and unilaterality (Figure 1). High signal intensity on T2-weighted image lesions can occur in regions other than the parieto-occipital areas, frequently involving the frontal lobes, basal ganglia, thalami, or brainstem.
可逆性后部白质脑病综合征典型的神经影像学表现为大脑后部受累,尽管这一点很早就被公认;但可逆性后部白质脑病综合征不典型的神经影像学表现,在本文的患者中则更常见,如:大脑前部明显受累、皮层出现病灶、可逆性后部白质脑病综合征再次发作、脑永久性损伤灶形成、病灶内出血、仅见单侧病灶(图1);T2像常可于额叶、基底节区、丘脑、脑干等顶-枕叶以外的区域见高信号病灶。
- 更多网络解释与脑学相关的网络解释 [注:此内容来源于网络,仅供参考]
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electrocorticogram:脑皮层电图
dystonia musculorum deformans:畸形性肌张力障碍 | electrocorticogram:脑皮层电图 | electrocorticography:脑皮层电图学
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encephalology:脑学
encephalography 脑照相术 | encephalology 脑学 | encephalomalacia 脑软化
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herniation:脑疝
包括不同地区的特性,诸如收住院的时间/开始给药的时间,监护病房的可用性,经过培训的职员、神经放射学技术和急症诊断专家等. 通过对中心/国家效应进行分析,大规模国际多中心试验有助于回答这些问题. 3、脑水肿引起脑疝(herniation)和死亡.
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phrenology:脑相学
早期的脑相学(Phrenology)认为,脑部(请注意,脑部是一种器官,此处准备讨论的是心灵)的每个部分,各自具备其功能. 各位可能见过脑相学说明图,显示脑部每个地区专门负责的功能. 其次是宗教小说家龙.哈伯(Ron Hubbard)所创的宗教科学(Scientology),
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cerebroid:如脑或大脑的
cerebrogalactoside | 脑糖苷, 脑苷(类) | cerebroid | 如脑或大脑的 | cerebrology | 脑学
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cerebrology:脑学
cerebrocentric 大脑中枢的 | cerebrology 脑学 | cerebromedullary 脑脊髓的
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cerebromedullary:脑脊髓的
cerebrology 脑学 | cerebromedullary 脑脊髓的 | cerebromeningeal 脑膜的
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Encephalic angioma:脑血管瘤
Enantiothamnus disease 对簇霉菌病 | Encephalic angioma 脑血管瘤 | Encephalology 脑学
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nosetiology:病原学,病因学
\\"缺脑畸形\\",\\"nosencephalia\\" | \\"病原学,病因学\\",\\"nosetiology\\" | \\"血液病,血病\\",\\"nosohemia,nosohaemia\\"
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porencephaly:孔洞脑(畸形)
Hankins说,ACOG文件建议儿科医师对患有脑病的新生儿进行标准化检查,以便确定患儿发生缺氧的时间,例如,如果生后72小时的影像学检查显示患儿有存在时间较长的神经系统异常,如脑室扩大、孔洞脑畸形(porencephaly)或多囊性脑软化,则可除