脂质体的

基本解释 (translations)

liposomal

与脂质体的相关的网络例句 [注：此内容来源于网络，仅供参考]

Homogeneous pressure and the number of passes through the homogenizer affect the entrapment efficiency and average particle size in different degrees.

以乳脂肪球膜磷脂为膜材，采用高压均质法制备免疫球蛋白G脂质体，研究了不同磷脂浓度、不同均质压力和不同均质次数对脂质体的包埋率和平均粒径的影响。

Both the increase of lipid peroxidation reaction rate and the shortening of the latent period were dependent on the pre-existed lipid peroxides in liposomes. Al3+ accelerated the oxidation of Fe2+ in liposomal system only when liposomes contain pre-exist peroxides. The addition of Al3+ to the liposomal suspension resulted in a marked increase of turbidity of the suspension and decrease of fluidity of the liposomes.

这可能是因为在脂质体存在的条件下，Al3＋加速了Fe2＋的氧化，且加速作用与脂质体中原先存在的过氧化物的含量有关；另一方面，Al3＋可以引起脂质体的聚集，表现为浊度的增加；测量脂质体上标记的脂肪酸自旋标记物5－ Doxyl stearic acid 的ESR 波谱发现： Al3＋降低了脂质体的膜脂的流动性。

Secondly, the thiolation of protein and the coupling of thiol protein with liposomes were studied, and large unilamellar vesicles with highly immunoactivity and stability were acquired.

首先系统研究了混合饱和类脂体系的脂质体的制备和脂质体的性质，然后研究了蛋白质的巯基化和巯基化的蛋白质与脂质体的偶联，从而获得了具有高的免疫活性的、稳定的大单层脂质体。

Through ultracentrifuge method the encapsulation efficiency was measured easily. Single factor investigation was carried out , and optimal formulation was decided .

建立了瑞利散射光测定微量NGF含量的方法；以超声法制备了小粒径的NGF脂质体；建立了超速离心法测定NGF脂质体包封率的方法；对影响NGF脂质体的包封率的因素进行考察，确定了最优处方。

Studies on stability indicated that PHGF proliposomes should be stored at low temperature and against light, which ensured unchange of their redispersity, content of drug, encapsulation efficiency, acid value and peroxide value. Liposomes were multilamellar vesicle structure under transmission electron microscopy. Average particle size was 0.65 micrometer, ranging from 0.09 micrometer to 1.21 micrometer. Cryoscopic value was 0.64 C determined by cryoscopic method, which was a little higher than that of isotonic solution.

以透射电镜观测PHGF前体脂质体再分散后的形态为囊泡状；激光散射法测得平均粒径为0.65μm，且粒度分布在0.09μm～1.21μm之间；该脂质体荷负电，ζ电位为-44.23mV；冰点降低法测得冰点降低度数为0.64℃，略高于等渗溶液冰点降低度数；测得粘度为1.83mPa·s，达到生理要求；此外，对PHGF脂质体的刺激性、溶血性、热原、异常毒性和过敏沈阳药科大学硕士学位论文拘要性检查表明均符合静脉注射给药的标准。

Specifically, itcontains 8 chapters.In chapter 1, the formation, structures, properties and the futureprospect of liposome were thoroughly reviewed;In chapter 2, the stibility and permeability of phopholipid -eleostericacid liposome were studied together with the effect of polymerizationof eleostearic acid. This membrane system was very sensitive to 〓,the effect of 〓 was clarified to increase the aggregation/fusion ofliposomes and made the permeability of mixed liposomes much higher;In chapter 3, two polymerizable conjugated diyne bolaamphiphiles were synthesized. They could form very stable mixed liposome, andthe diyne could be polymerized by UV light in bilayer liposomes, as aresult, the stability of mixed liposome against solvent or surfactantafter polymerization were enhanced. In chapter 4, two kinds of amphiphilic amino acids were synthesized andstable liposomes were formed therefrom After the condensationpolymerization of amino acid in bilayer liposomes, stable polypeptide liposomes were obtained, which had lower phase transition temperatureand higher permeability.In chapter 5, four kinds of glycolipids were synthesized and theiraggregation behavior in water was comparied. When incorporated intophospholipid bilayer membranes, they could increase the phase transitiontemperatures and inhibit the aggregation and fusion of mixedliposomesat lower temperature.In chapter 6 and 7, three kinds of steroidal bolaamphiphiles withdifferent chain lengths were synthesized. Incorporation of steroidalmoiety to the center of lipid bilayer membrane obviously increased themobility of lipid membrane and shifted Tc to lower temperature side incomparasion with cholesterol. The bolaamphiphile which was shorter thanthe hosted lipid bilayer membrane thickness influenced the lipid packingmore obviously.

全文共分8章：第一章对脂质体的形成、结构、性质及展望进行了较为详细的文献综述；第二章研究了磷脂-桐酸脂质体的稳定性，通透能力及桐酸的聚合对这些性质的影响；磷脂-桐酸混合脂质体为一类对〓灵敏的脂质体，〓的作用首先是使脂质体集聚然后使脂质体融合，并加速内包荧光物的释放；第三章通过合成两种可聚合共轭双炔双极性双亲分子DDCA，DDOL，研究了共双炔分子在双分子层脂质体膜上的聚合及对脂质体性质的影响，聚合可以提高脂质体相对于溶剂及表面活性剂的稳定性；第四章合成了两类氨基酸为极性基团的双亲分子，它们均可以在超声下形成稳定的脂质体结构；氨基酸基团可以在脂质体上进行缩聚反应，若聚合后脂质体表面仍有足够的亲水能力，则可得到稳定的多肽型脂质体；聚合后脂质体的相变温度降低，通透能力增加；第五章合成了四种亲水基团为单糖基的双亲分子GL-l，GL-2，GL-3， GL-4，研究了它们在水中的分散情况、集合体形态与分子结构的关系；在DMPC双分子层膜中加入糖脂分子可以使脂质体的相变温度提高，阻止脂质体在低温放置时的集聚与融合；第六章-第七章合成了三种不同碳链长度的双极性含胆甾环双亲分子 CL-1，CL-2，CL-3；它们可以象胆固醇一样与磷脂混合形成稳定脂质体，胆甾环基团位于脂质体双分子层膜的中间；与胆固醇的作用相反，它们可以增加磷脂双分子层膜的流动性，降低混合脂质体的相变温度；三种分子的作用与其碳链长度和磷脂双分子层膜的厚度有关，比膜厚度短的分子影响最大。

Zeta potential was -44.23 millivolt. Viscosity was 1.83 mpa. All of which were coincided with physical desire. In addition, the tests of PHGF liposomes including irritation, hemolysis, pyrogen, anomaly toxicity and hypersensibility, proved that the preparation reached the standard of intravenous injection entirely. Taking glutamic pyruvic transaminase and malondialdehyde in mice as index, studies on pharmacodynamics after hepatic injure caused by tetrachloromethane in mice indicated that GPT level (P.001) and MDA yieldment P

以小鼠CCli急性中毒性肝损伤为模型，以动物血清中谷丙转氨酶（GP水平与肝脏中丙二醛p A烨成量为指标，进行PHGF脂质体的药效学试验，结果表明P＊＊F脂质体能显著降低GP T水平o＜0刀01）与MD A 生成量厌＜o.05）；大鼠组织形态的观察表明高剂量＊＊＊F脂质体能使肝脏 0 内皮细胞增生活跃，提高肝细胞的免疫功能，对受损肝细胞具有修复作用；同样小鼠碳廓清试验也显示PHGF脂质体较市售粉针具有更好的机体免 p 疫作用o功刀01），达到制剂设计目的，获得较好的结果。

Liposome properties and biological behaviors can be controlled by surface modification. Attachments of hydrophilic polymers, such as poly, enable them to have a prolonged circulation time without being opsonized and recognized by mononuclear phagocytic system.

通过表面修饰可以改变脂质体的性质和生物学行为：在脂质体表面修饰亲水性高分子可以阻碍血浆成分的调理作用，减少脂质体被网状内皮系统识别和摄取，使脂质体具有长循环的特点；在脂质体表面修饰特异性的配基，能使脂质体具有主动靶向的特性。

Including the soybean lecithin separation purification, gamma - the linolenic acid separation and the purification, as well as gamma - linolenic acid fat 质体 Bao He studies and so on, and carries on optimal using the orthogonal experiment to the above craft.

其中包括大豆卵磷脂的分离纯化，γ-亚麻酸的分离和纯化、以及γ-亚麻酸脂质体包合研究等等，并利用正交试验对上述工艺进行优选。

East valuable Jin Danzhong the gamma - linolenic acid and the soybean lecithin will make the fat 质体 both to conform to the original group side principle and to be possible to increase the preparation the stability and the curative effect.

将东宝金丹中γ-亚麻酸和大豆卵磷脂制成脂质体既符合原组方原则又可增加制剂的稳定性和疗效。

与脂质体的相关的网络解释 [注：此内容来源于网络，仅供参考]

liposome：脂质体

杨锋(福建医科大学化学教研室 350004);林友文(福建医科大学化学教研室 350004);赵剑曦(福州大学化学系 350002) 脂质体(Liposome)是磷脂依靠疏水缔合作用在水中自发形成的一种分子有序组合体,

liposome：脂质小体

电镜下可见脂滴形成于内质网中,为有界膜包绕的圆形均质小体,称为脂质小体(liposome),其电子密度一般较高. 初形成的脂滴很小,以后可逐渐融合为较大脂滴,从而可在光学显微镜下察见,此时常无界膜包绕而游离存在于胞浆中.

Long-circulating liposome：长循环脂质体

90 年代起国外Klibanor 等研究出第二代脂质体,称为空间脂质体(Sterically Stabilized Liposome) 或长循环脂质体(Long Circulating Liposome). 以往脂质体因在体内与促进吞噬细胞具有吞噬能力的调理素(Opsonin) 结合或通过受体介导途径迅速被单核吞噬细胞降解,

lipophore; xanthophore：含红、黄、橘红色素的色素体

亲脂性的 lipophilic | 含红、黄、橘红色素的色素体 lipophore; xanthophore | 脂质体 lipoplast

extracellular matrix：胞外基质

6.胞外基质(extracellular matrix)主要用于用于维持组织结构,对细胞功能的影响不大13.将光驱动的质子泵-噬盐菌菌紫质(bacteriorhodopsin)与ATP合成酶置于同一脂质体中,在光照下可由ADP和磷酸产生ATP.

lipotrophic：脂肪增多的;肥胖的

liposome脂质体 | lipotrophic脂肪增多的;肥胖的 | lipotrophy脂肪增多

Liposomes：脂质体

由于它的氨基酸组成及分子结构决定了MT在生命过程中起着重要的生理作用.本项目是脂质体在化妆品上的具体应用,因"脂质体"(Liposomes)是一种脂双层膜的封闭微胶囊,类似人体细胞结构,具有生物膜的功能与特性,与人体细胞有很强的亲和性,因此,"脂质体"(Liposomes)化妆品的功效独特.

cationic liposomes：阳离子脂质体

带正电阳离子脂质体(Cationic liposomes)则不同,DNA并没有预先包埋在脂质体中,而是带负电的DNA自动结合到带正电的脂质体上,形成DNA-阳离子脂质体复合物,据认为一个约5kb的质粒会结合2-4个阳离子脂质体,从而吸附到带负电的细胞膜表面,

cationic liposomes：脂质体

阳离子脂质体(cationic liposomes)作为反义寡聚脱氧核苷酸()等基因治疗药物的一种传递系统,其优点早已为人所识,它主要通过电荷作用有效的将带负电荷的核酸等药物结合到脂质体表面或包裹在内部,这样既提高了载药率,同时又保护核酸免受核酸酶的攻击.

symplast：共质体

5.共质体(symplast) 答案:由胞间连丝把相邻细胞的细胞质连成一体的体系. 1.生物膜(biomembrane )答案:指细胞中主要由脂类和蛋白质组成的、具有一定结构和生理功能的膜状组分,即细胞内所有膜的总称. 包括质膜、核膜、各种细胞器被膜及其他内膜.