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On the other hand, the hepatic microsomal aminopyrine demethylase activity was obviously inhibited 2 hours after administration of the same dose of SY-801 and SY-640, while the content of hepatic cytochrome P-450 was not affected.
体外实验表明，SY-801和SY-640对正常小鼠、3-甲基胆蒽（3-MC）处理小鼠及苯巴比妥处理小鼠小鼠肝微粒体氨基比林脱甲基酶活性都具有明显的抑制作用，其中对3-MC处理小鼠肝微粒体氨基比林脱甲基酶活性抑制作用最显著。
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AIM: This experiment was performed to evaluate the significance of the expression of different types of protein kinase C in lung squamous cell carcinoma induced by methylcholanthrene.
目的：研究不同亚型蛋白激酶C在肺鳞癌组织中的表达，以探讨它们在甲基胆蒽诱发的实验性肺鳞癌发生发展中可能的作用。
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AIM: This experiment was performed to evalu at e the significance of the expression of different types of protein kinase C in lung squamous cell carcinoma induced by methylcholanthrene.
目的 ：研究不同亚型蛋白激酶C在肺鳞癌组织中的表达，以探讨它们在甲基胆蒽诱发的实验性肺鳞癌发生发展中可能的作用。
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Methods Lung squamous cell carcinoma was induced with methylcholanthrene in iodized oil in Wistar rats. Ninty-one rats were used for this experiment, and the rats were sacrificed on the 20th, 40th, 50th, 60th, 70th and 80th days respectively.
方法经肺叶支气管内灌注甲基胆蒽碘油溶液对91只Wistar大鼠诱癌，分别于灌注后第20、40、50、60、70、80天分批处死动物并采取血清。
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In this study, we found that β-catenin, c-JUN, c-myc and GSK3β might be involved in squamous metaplasia of airway epithelium induced by methylcholanthrene, vitamin A deficiency or cigarette smoking by investigating the rat model of squamous metaplasia.
本项目通过维生素A缺乏、吸烟及气管内注入甲基胆蒽复制体外气道上皮鳞化动物模型，发现β-连环素、c-JUN、c-myc 及GSK3β可能介导了甲基胆蒽、VitA 缺乏与吸烟所致的大鼠支气管上皮鳞状化生。
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Results In spheroids culture system, under the condition of apoptosis of src-transformed cells, the apoptosis of chemical transformed cells were also induced by normal cells, but BPV-transformed cells were resistant.
结果：在球体细胞培养实验系统中，在src转化细胞产生凋亡的条件下，甲基胆蒽转化细胞同样能产生凋亡，而BPV转化细胞则抵抗了由周围正常细胞所致的凋亡。
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In addition concentrated QC can also inhibit the growth of skin tumor caused by shope papilloma virus. But neither concentrated QC, nor D77 could inhibit the mouse skin tumors caused by chemical carcinogen and tumor promoter with initiation and promotion protocol.
另外中药QC膏剂还可抑制Sh〓乳头瘤病毒所致的兔乳头瘤；D〓腹腔注射时对S-180腹水瘤也有一定的抑制作用；但无论是中药QC膏剂，或D〓对化学致癌物3-甲基胆蒽与促癌物巴豆油合用诱生的小鼠皮肤瘤无抑制作用。
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methylcholanthrene：甲胆蒽 甲基胆蒽
methylchlorothiazide甲基氯噻嗪 | methylcholanthrene甲胆蒽 甲基胆蒽 | methylcinnamate肉桂酸甲酯