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OBJECTIVE: To prepare cholesterol succinyl chitosan anchored liposomes, and to investigate the effect of CHCS anchored liposomes on the release property in vitro of loading drugs taking epirubicin as a model drug.
目的:通过"锚定"的方式制备胆甾醇琥珀酰基壳聚糖锚定脂质体,并以表阿霉素作为模型药物,考察其对包载药物体外释放性质的影响。
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A series of cholesterol-bearing O-carboxylmethyl chitosan conjugates with different degrees of substitution of the cholesterol moieties and cholesterol-bearing chitosan were synthesized by the succinyl linkages and characterized by Fourier transform infrared, Proton Nuclear Magnetic Resonance (~1H NMR) and elemental analysis. These hydrophobized chitosan derivatives were amphiphilic in nature and their self-aggregation behavior in aqueous media was evaluated by the fluorescence probe technique.
课题的主要研究内容如下:采用化学的方法合成了不同分子结构、不同取代度的系列胆甾醇基壳聚糖衍生物—胆甾醇基壳聚糖和胆甾醇基-羧甲基壳聚糖,并应用先进的分析手段电位滴定、红外光谱法(IR、核磁共振波谱法等对原料、中间产物以及产物进行了结构表征,衍生物分子中的胆甾醇基取代度(3.2%~12.5%)采用元素分析的方法进行检测。
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Self-assembled nanomicelles of N -cholesterol succinyl O -carboxymethyl chitosan were prepared by probe sonication method. The amphiphilic property and the critical micelle concentration of CCMC were determined by fluorescence probe technique; the morphology and the size of CCMC self-assembled nanomicelles were analyzed by transmission electron microscopy and the dynamic laser light scattering.
以 N -胆甾醇琥珀酰基- O -羧甲基壳聚糖(CCMC,胆甾醇基取代度6.9%)为原料,在水溶液中通过探头超声处理制备其自组装凝胶纳米胶束,采用稳态荧光探针法考察临界胶束浓度,并通过透射电镜和动态激光散射仪检测胶束的形态大小。
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Bicyclic compounds containing a phenyl or pyridyl ring fused to a cycloalkyl or heterocyclic ring, to which is attached a 5-membered heterocyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.
本发明涉及含有连接在5元杂环上的稠合至环烷基或者杂环的苯基或者吡啶基环的二环化合物,包括其药学上可接受的盐和前药,它们是G蛋白偶联受体40(GPR40)激动剂并且可以用作治疗性化合物,特别是在2型糖尿病和与这些疾病相关的症状中用作治疗性化合物,这些症状包括肥胖病和脂质疾病,比如混合或者糖尿病型血脂异常症、血脂质过多、高胆甾醇血和高甘油三酯血症。
- 更多网络解释与胆甾醇基相关的网络解释 [注:此内容来源于网络,仅供参考]
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Cholesteryl oleate:胆甾醇油酸酯
cholesteryl nonanoate 胆甾醇壬酸酯 | cholesteryl oleate 胆甾醇油酸酯 | cholesteryl oleoyl carbonate 胆甾醇油酰基碳酸酯
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cholesterosis:胆甾醇沉着病
cholesterincholesterol 胆固醇 | cholesterosis 胆甾醇沉着病 | cholesteryl 胆甾醇基
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cholesteryl:胆甾醇基
cholesteryl propionate 胆甾醇丙酸酯 | cholesteryl 胆甾醇基 | cholet 新奇花色手帕
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choletelin:胆特灵
cholesteryl 胆甾醇基 | choletelin 胆特灵 | cholinergic 胆碱能的