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Objective To study the diagnostic value of adenosine deaminasein all kinds of the pa-tients with liver disease.Methods 212patients of hepatitis in our hospital were selected,135cases were male,and75were female,the average age was(39.6±5.2)years old,in other hand,100blood donors were selected as con-trol group,the value of ADA and the conventional item such as GGT,ALT were determining and a contradistinctive analysis were conducted.Results The item of ADA and the conventional item such as GGT,ALTwere not different in the patients of different kind of liver disease,especially in the patients of chronic persistent hepatitis and chronic active hepatitis,the value of positive rate were92.0%and28.9%,respectively.
目的 测定各类型肝脏疾病病人血清腺苷脱氨酶(adenosine deaminase,ADA)活性值,分析ADA测定结果在各种肝脏疾病中的不同变化,评价ADA测定在肝脏疾病诊断中的应用价值;方法以在我院感染科住院肝炎病人共212例为检测对象,其中男性135例,女性75例,平均年龄(39.6±5.2)岁,以献血员100例为正常对照,对其ADA测定结果进行统计分析,并与传统肝功能检测项目做对比研究;结果 ADA和传统肝功能检测指标在不同类型肝脏疾病中测定值和阳性率各有所不同,特别在慢性活动性肝炎、慢性迁延性肝炎中的阳性检出率有显著不同,分别为92.0%和28.9%,有显著差异(P.01)。
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In an effort to develop a simple method for identifying patients who may have fatty liver disease, Dr. Bedogni and colleagues used data from the Dionysos Nutrition and Liver Study to determine the degree to which drinking habits, anthropometry, and metabolic parameters contribute to the risk for the condition in 216 patients with suspected liver disease but no hepatitis B and C infection as well as in 280 age- and sex-matched controls. All participants were from the same town in northern Italy. The presence of fatty liver disease was confirmed via ultrasonography. Results were presented here by Vittorio di Maso, MD, another researcher at the Liver Research Center, at the 41st annual meeting of the European Association for the Study of the Liver.
为了发展出一个简单的方法於鉴定脂肪肝疾病病患,Bedogni 医师及其同僚使用迪奥尼修斯营养与肝脏研究的数据,对280位年龄与性别相符者之中的216位疑似有肝脏疾病但无B型或C型肝炎的病患,加以区别饮酒习惯、人体测量学、导致风险的代谢参数等,所有参与实验者都是来自义大利北部的一个城镇,藉由超音波扫瞄确定出现脂肪肝疾病;研究结果在欧洲肝脏研究学会第41届年会由前述肝脏研究中心的另一位研究员、Vittorio di Maso 医师发表。
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The comparisons of biochemistry between OP and OR rats The differences between OP and OR rats included not only body weight, but lipids metabolism and insulin sensitivity as well, characterized with insulin resistance, increasing in serum free fatty acids and ketone body, and hepatic TC and TG in OP rats. However, no significant differences were observed in serum TG, TC, LDL, HDL and fasting glucose between OP and OR rats.⑶Comparisons of metabolites in serum, urine and liver tissue between OP and OR rats①There were significant differences in amino acids concentration between OP and OR rats,especially in liver tissue, such as high concentrations in ketogenic and glucogenic amino acids in OP rats, suggesting differences in amino acids metabolism;② The different metabolites between OP and OR rats included increasing of various saturated fatty acids and decreasing of polyunsaturated fatty acids in OP rats;③The urinary metabolites analysis indicated that different structure or metabolism of gut microflora might exist between the two phenotypes, which probably influenced the regulation of body weight gain;④The end-products of catecholamines in urine and intermediates of krebs cycle in serum in OP rats were all up-regulated, suggesting that the activity of sympatheic nervous system and energy metabolism was higher in OP rats than OR rats.
胰岛素耐受实验和胰岛素敏感指数表明OP动物的胰岛素敏感性较OR动物下降,而OP大鼠血清中游离脂肪酸、酮体、肝脏总胆固醇和甘油三酯水平显著升高;但是,OP与OR大鼠血清中总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白和空腹血糖等的水平并无显著性差异;⑶肥胖易感与肥胖抵抗大鼠血清、尿液和肝脏组织提取物中代谢物的比较研究表明:①OP与OR大鼠的血清、尿液和肝组织提取物中多种氨基酸的含量存在显著差异,并以肝组织中的差异氨基酸数量为最多,包括各种生酮和生糖氨基酸水平在OP组的升高,说明氨基酸代谢的差异是两种体重表型大鼠之间存在的重要差异特征之一;②OP与OR动物肝脏和血清差异代谢物中包含多种饱和长链脂肪酸的升高如十四烷酸、十六烷酸、硬脂酸等和多不饱和脂肪酸的下降如亚油酸和花生四烯酸,说明两种体重表型动物的肝脏脂肪酸代谢存在明显差异;③长期高脂饮食喂养后,动物的尿液代谢物分析表明OP与OR动物体内的肠道菌群结构存在差异,这些菌群上的差别可能在动物体重增长的调节上产生影响;④与OR动物相比,OP动物尿液代谢物中儿茶酚胺类递质的代谢终产物如高香草酸、扁桃酸和4-羟基苯乙酸明显升高。
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Results ①It had greatly verisimilar image for the reconstructed 3D liver moulds with artery, vein, portal vein and bile duct; By liver seeing through, it had high fidelity and strong 3D effect for the intrahepatic artery, vein, portal vein and bile duct, and their spatial disposition and course and correlationship were shown clearly.
结果 ①重建的肝脏模型具有肝脏、肝动脉、肝静脉、门静脉和胆道系统,形态逼真,立体感强;肝脏可视化后,肝脏内部管道空间立体感强,肝动脉、肝静脉、门静脉和肝胆管的分布、行程以及相互关系明晰。
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The SOD and the LDH-1 activities and EST (R_f=0.17 and R_f=0.72) at 1℃weresignificantly higher than the values of the room temperature(P<0.05), but the total enzymeactivities of LDH, G6PDH and EST at room temperature and 1℃were similar(P>0.05).This showed well-developed anoxia tolerance of the Heilongjiang wood frog to maintainplasma viability when low temperature interrupts the delivery of oxygen and substrates. LDH-1rose significantly avoided the liver lactic acid accumulation that may created the liver to bewearied. EST (R_f=0.17 and R_f=0.72) rose may enhance the ester metabolism to offer muchenergy. These showed steady metabolic rate and relative stable organism environment of theHeilongjiang wood frog to survive under low temperature.Native PAGE separated proteins of liver tissue successfully on the better condition is 6%final gel concentration and there were 15~19 bands identified on this condition.
同功酶电泳图谱显示,1℃组与室温组黑龙江林蛙肝脏LDH酶活性差异不显著,均以LDH-5为主,但1℃组LDH-1显著高于室温组(P<0.05),推测黑龙江林蛙为适应低温低氧环境,增强LDH-1酶活性以较好的利用乳酸,避免因大量乳酸形成造成肝脏疲劳;而1℃组肝脏G6PDH酶活性无显著变化,进一步说明低温条件下葡萄糖戊糖途径和糖酵解作用的互相协调,维持机体代谢的稳定;1℃组和室温组EST总酶比活力无显著变化,但1℃组中R_f=0.17和R_f=0.72的EST同工酶显著升高(P<0.05),推测在低温条件下黑龙江林蛙可能通过选择性增强部分酯酶同功酶活性,增加肝脏酯类物质代谢,为机体提供维持生命必需的最低能量。
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The GLDH gene expression showed a continuing reinforcing trend after morphine injection compared with control group, even after drug withdrawal. The ADA mRNA contents in morphine group Ⅰ,Ⅱ and withdrawal group Ⅰ,Ⅱ were 2.65,1.89,1.18, and 0.87-fold of that in control group dividedly. The ADA gene expression increased after morphine injection and fell gradually after withdrawal.
结果:吗啡Ⅰ、Ⅱ组及停药Ⅰ、Ⅱ组大鼠肝脏GLDH mRNA含量分别为对照组的1.02、1.09、1.16及1.46倍,吗啡给药大鼠肝脏中GLDH基因表达随给药时间延长而持续增强,自然停药一定时间内大鼠肝脏中GLDH mRNA含量仍持续增高;吗啡Ⅰ、Ⅱ组及停药Ⅰ、Ⅱ组大鼠肝脏ADA mRNA含量分别为对照组的2.65、1.89、1.18及0.87倍,吗啡Ⅰ、Ⅱ组大鼠肝脏ADA的基因表达均比对照组明显增高,自然停药后大鼠肝脏ADA表达逐渐下降,停药7 d时下降至接近对照组水平。
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The positive signal of ER and ER mRNA distributed in parenchymal and non-parenchymal hepatic cells, especially near the hepatic centrolobular and periportal areas. Ovariectomy decreased ER level and ER mRNA expression significantly (P<0.05). Hepatic ER and ER mRNA concentration were elevated after treatment with estrogen in both ovariectomy and sham ovariectomy fibrotic groups (P<0.05), and the elevation of ER was correlated with a marked decrease in hepatic damage and fibrosis.
5肝脏ERα及其mRNA基因的表达分布于肝细胞及肝脏非实质细胞,特别以肝脏中央静脉和门脉周围为主;卵巢切除减少ERα及其mRNA基因的表达(P<0.05);雌二醇治疗在肝纤维化和卵巢切除大鼠均提高肝脏ER及其mRNA基因的表达(P<0.05),其增加程度与肝脏组织学损伤、纤维化指标的降低程度以及肝脏胶原沉积减少相平行。
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In order to understand the expressed genes, construct the known gene expressed profile, study the tissue-specific genes and the common genes from pig and chicken; In order to do primary researches for comparative genomics, functional genomics, QTLs mapping, animal molecular breeding and so on, we have constructed 3 cDNA libraries of Xiang Pig muscle tissue, Silkie Fowl muscle tissue and liver tissue, sequenced a large scale ESTs and analyzed their bioinformation from the ESTs of Silkie Fowl muscle tissue and liver tissue in our study.
为全面了解肌肉组织和肝脏组织的基因表达类型,构建猪、鸡肌肉组织和肝脏组织的功能基因表达谱,研究肌肉组织和肝脏组织的特异表达基因及这两种组织的共同基因;为比较基因组学的研究、功能基因组学的研究、QTLs定位等的动物分子育种做前期基础科研工作,本研究构建了香猪肌肉组织、丝毛乌骨鸡肌肉组织和肝脏组织的3个cDNA文厍,并对丝毛乌骨鸡的肌肉组织和肝脏组织进行了大规模的ESTs测序及其生物信息学的初步研究。
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The profile of gel-filtration of liver homogenate showed that zineis the main metal bound with MT in normal mice without giving copper,but copper isthe main metal bound with MT after oral administration of copper acetate.
分离正常小鼠肝脏和给铜后荷瘤小鼠肝脏中MT可见,小鼠未服用铜前肝脏中锌是MT的主要结合金属,而在给铜后肝脏中MT的主要结合金属是铜。
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"Working with mice, we found that glucose levels were elevated and there was glucose production from a 'precursor', a source not normally metabolised."Other results in the study show that to some extent ARNT is regulated by insulin, so that insulin resistance in itself will contribute to a decrease in ARNT. If liver cells are treated with insulin, there will be a small increase in ARNT protein. The insulin will also help move the ARNT into the nucleus of the cell, where it does its job as a master regulator.
胰岛素绝对或相对不足时,肝脏内一种称之为 ARNT 的转录因子减少达90%,而 ARNT 与控制肝脏生产和释放葡萄糖的基因表达有关, ARNT 减少,肝脏生产和释放葡萄糖增加。2型糖尿病时,胰岛素相对不足不仅使肝脏内 ARNT 减少,也导致胰岛β细胞内 ARNT 减少,使得胰岛素生成减少和释放延迟。
- 更多网络解释与肝脏相关的网络解释 [注:此内容来源于网络,仅供参考]
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The liver is a vital organ of the human body:肝脏是人体的重要器官
3. This point is vital to my argument. 这一点对我的论据极为重要. | 4. The liver is a vital organ of the human body. 肝脏是人体的重要器官. | 5. vital dyes;vital staining. 活体染剂;活体染色
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khepatic arteriography:肝动脉造影术 hepato- 肝,肝脏
heparin 肝素 | khepatic arteriography 肝动脉造影术 hepato- 肝,肝脏 | hepatolienal 肝脾的
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caudate lobe:尾状叶(肝脏)
"尾椎神经","caudal nerve" | "尾状叶(肝脏)","caudate lobe" | "尾状突(肝脏)","caudate process"
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caudate process:尾状突(肝脏)
"尾状叶(肝脏)","caudate lobe" | "尾状突(肝脏)","caudate process" | "网脂","caul fat"
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Lier Transplantation:肝脏移植
The Canadian Journal of Gastroenterology 加拿大胃肠病学杂志 | Lier Transplantation 肝脏移植 | Hepatology 肝脏病学
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liver transplantation:肝脏移植手术
liver transplantation 肝脏移植 | liver transplantation 肝脏移植手术 | liver transplantation 移植肝脏
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The liver damage is more worrisome:肝脏损伤令人忧虑
The kidney damage isn't so bad.|肾脏损伤并不严重 | The liver damage is more worrisome.|肝脏损伤令人忧虑 | There's no dialysis for livers.|肝脏不可被透析
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cirrhotic:肝脏硬化症的
肝脏营养素hepatinica | 肝脏硬化症的cirrhotic | 肝造血素anahaeminanahemin
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hepatologist:肝脏病学家
肝脏病学hepatology | 肝脏病学家hepatologist | 肝脏病状态hepatism
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Liver Tissues:肝脏
肝脏:Liver ablation | 肝脏:Liver Tissues | 调肝:liver