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Results the No.1 litholytic compounds dissolved the cholesterol gallstone(500mg)in no more than 25 min (21.6±4.9 min),less influence to blood biochemical,no harm to the other organs of rabbits except gallbadder.
结果 复方溶石剂1号对500mg的胆固醇结石溶解时间少于25min(21±4.9min)，对动物的血液生化指标影响不大，除胆囊外未对全身其他脏器造成损害。
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To improve the effect of CDCA on dissolving cholesterol gallstone, the water-soluble copolymers as polycarboxylic acid of comb-like copolymers and C_(60)-PCC were synthesized, which being used for modification of CDCA and strengthening effects of CDCA on dissolving the cholesterol gallstones by their entropy-repelled properties of comb-shaped side chains in buffers of phosphate and in model bile.The design theory of polymer was mainly employed to synthesis the conjugate of PCC-CDCA and C_(60)-PCC-CDCA by C_(60), polyoxyalkylene allylalkyldiether and maleic anhydride, which were copolymerized with AIBN as initiator, and then PCC or C_(60)-PCC were reacted with CDCA. The structures of the copolymers and the conjugates of PCC-CDCA and C_(60)-PCC-CDCA were confirmed with IR, TLC and TEM. The dissolving effects and the dissolution kinetics mechanism of cholesterol gallstone was inverstigated in PBS and in model bile of different cholesterol saturated index at pH7.4, including PCC-CDCA or C_(60)-PCC-CDCA.
利用高分子设计理论，以烯丙基聚氧乙烯基醚、顺丁烯二酸酐、C_(60)和CDCA为原料，以偶氮二异丁腈为引发剂，合成具有梳状侧链结构的梳状共聚物-CDCA结合物和C_(60)-梳状共聚物-CDCA结合物，以IR、TLC和TEM法表征共聚物的结构，并在pH7.4的PBS液和不同胆固醇饱和指数的模拟胆汁中进行溶石效果的研究，探讨在PBS液和不同CSI的模拟胆汁中结合物溶解胆固醇结石的效果和溶解动力学机制。
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litholytic：溶石的
litholyte 溶石液灌注器 | litholytic 溶石的 | litholytic 结石溶解剂
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litholytic：结石溶解剂
litholytic 溶石的 | litholytic 结石溶解剂 | lithomargeterratolite 密高岭土
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litholytic：溶石的 结石溶解剂
lithologic unit 岩性单位 | litholytic 溶石的,结石溶解剂 | litholytic therapy 溶石疗法
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litholytic therapy：溶石疗法
litholytic 溶石的,结石溶解剂 | litholytic therapy 溶石疗法 | lithophile element 亲石元素,亲岩元素