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The rat model of schizophrenia was prepared by MAP injection i.p. and the nucleus lesioned by direct current to observe the changes in stereotypic behavior of MAP + lesion rats. Expressions of DRD2 in the prefrontal lobe and temporal lobe and limbic system and brain stem were then detected by in situ hybridization.
经腹腔注射MAP制备精神分裂症模型,采用立体定向-直流电毁损伏隔核,观察大鼠刻板行为变化;并采用原位杂交法观察额叶、颞叶、边缘区及脑干部位的D2受体表达。
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Perfusion in the right parietal lobe in group2 was significantly lower than in group1 (P.01).(2)Average perfusions were higher in the right temporal and parietal lobes than in the left in all 3 groups.(3)Gray matter volumes were significantly smaller in group3 than in group2 (P.05); total cerebral spinal fluidsvolumes were significantly larger in group3 than in group1 and group2(P.05); right hippocampus volumes were significantly smaller in group3 than in group1 (P.05). Conclusions Age-related change of cerebral blood perfusions in the healthy elderly over 65 years is characterized with hypoperfusion in the right parietal.
结果(1)经方差分析,第2组和第3组脑组织几乎所有部位的灌注均低于第1组,其中第2组右顶叶灌注的放射性计数比值为0.87±0.18,低于第1组(RAR=0.98±0.17;P.01);(2)经配对t检验,除第2组的双侧顶叶外,3组颞叶和顶叶的灌注均为右侧高于左侧(P.01和0.05);(3)经方差分析,第3组的灰质体积占颅内容积的百分比[(47.59±1.26)%]小于第2组[(49.43±1.30)%],总脑脊液体积占颅内容积的百分比[(14.61±3.16)%]大于第1组[(12.41±0.73)%]和第2组[(11.94±1.27)%],右侧海马体积[(2.04±0.23)cm3]小于第1组[(2.27±0.20)cm3],P均。05。
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transtemporal:经颞叶的
transsexualism 异性认同癖 | transtemporal 经颞叶的 | transthalamic 经丘脑的
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transthalamic:经丘脑的
transtemporal 经颞叶的 | transthalamic 经丘脑的 | transversal 横向的