纤维化的

基本解释 (translations)

fibrotic  ·  Fibrotic

与纤维化的相关的网络例句 [注：此内容来源于网络，仅供参考]

aim to study the efficaciousness of wuling cap-sules for hepatic fibrosis in rats.methods rat models with hepatic fibrosis were induced by ccl4 compound factors and then treated with wuling capsules.pathology of liver sections,hyaluronic acid and procollagencontents in rat liver and serum were examined respectively.results pathological examinations showed that the liver cells of mod-el rats were injured seriously.collagen fibers proliferated and dissected hepatic lobules in model rats.wuling capsules could protect liver cells and reduce degrees of hepatic fibro-sis.the best effects were achieved at3.0g?

目的 研究五灵胶囊对大鼠肝纤维化的作用。方法采用以四氯化碳为主的复合因素致大鼠肝纤维化，观察五灵胶囊对肝组织病理学、肝组织和血清中羟脯氨酸、ⅰ，ⅲ型前胶原含量的影响。结果病理学检查显示，模型组大鼠肝细胞损伤严重，胶原纤维大量增生，形成假小叶。五灵胶囊组大鼠肝细胞结构破坏不明显，肝纤维化程度轻，在3.0g？kg-1 时治疗效果最好。

ConclusionGR mRNA upregulation in lung tissue could be one of the mechanism of glucocorticoid's effective cure for pulmonary fibrosis,and GR mRNA downregulation in lung tissue in renalyang asthenia syndrome could be one of cause of glucocorticoid's noneffective therapy for pulmonary fibrosis,in addition,the Chinese traditional medicine with warming Yang effect could be effective therapy for pulmonary fibrosis.

结论肺组织GRmRNA表达的上调是糖皮质激素防治肺纤维化之所以有效的机理之一，而肾阳虚状态下肺纤维化肺组织GRmRNA表达下调是临床上许多肺纤维化病人对糖皮质激素不敏感的原因之一，同时，温阳药也极可能具有防治肺纤维化的作用。

objectiveto study the protective and therapeutic effects of the extract of retinervus luffae fructus and carapax trionyei on con a-induced hepatic fibrosis in balb/c rats.methodsthe hepatic fibrosis in rats was first induced by intravenous injection of concanavalin a, the treatment in both protective and therapeutic stage was performed by subcutaneous injection of the extract.

目的 探讨鳖甲复方中药针剂对con a在balb/c雄性小鼠中诱导肝纤维化的预防和治疗作用。方法采用con a诱导肝纤维化，造模期间及造模成功后均用复方中药针剂干预药剂组，比较组间各项血液生化指标和肝脏组织学方面的差异，以探讨针剂对肝纤维化的预防和治疗作用。

Establishing experimental animal model of immunized fibrosis could contribute to research on extracellular matri and cytokine. they turns out that the ingredient of Desmodium pulchellum can relieve extra growth and deposit of ECM and adjust the level of relative cytokine, such as TGF-β1 and IFN-γ, benefit to effect of hepatic anti-fibrosis.

结果证明排钱草生物碱类成分能减轻肝纤维化的基本病理改变即减少肝细胞外基质的过度增生和沉积，调节与肝纤维化密切相关的TGF-β1、IFN-γ等细胞因子水平，向着有利于减轻肝纤维化的方向发展。

Although the pathogenesis is not very clear, new understandings about development of pulmonary fibrosis has appeared in company with impenetration of cell biology research and molecular biology research. In a word, research of pulmonary fibrosis gradually appears to be integrated and multidisciplinary crossover.

尽管肺纤维化发病机制目前尚不完全清楚，但随着细胞生物学和分子生物学研究不断深入，对肺纤维化的发生、发展机制有了许多新得认识，肺纤维化机制的研究正逐渐走向整体化和多学科交叉方向。

Objectives To study the expressions of STAT1 and PDGF in lung tissue of pulmonary fibrosis model induced by bleomycin in rats, and discuss the possible mechanism.Methods Thirty Wistar rats were randomly divided into two groups (15 in each group), they were bleomycin group and control group.①The BLM group was intratracheally instilled with belomycin (5mg/kg);② NS group was intratracheally instilled with saline (5mg/kg).

目的 观察肺纤维化鼠肺组织信号转导和转录活化因子1（STAT1）和血小板源性生长因子表达的变化，探讨其在肺纤维化的作用机制方法 30只Wistar大鼠随机分博莱霉素组和对照组，①BLM组：气管内灌注BLM（5mg/kg）诱导肺纤维化；②NS组：气管内灌注NS。

4The Masson trichrome stain can be used for an important method for the observation of the fibrostic cells, The changes of the mast cell could be considered as an assist marker for the observation of the liver fibrogenesis.In addition the concentration of the hepatic hydroxyproline could be used for diagnosis of the hepatic fibrosis. clinical and experimental study.

Masson三色染色可以作为肝纤维化肝硬化组织细胞观察的一种重要方法：肝纤维化过程中，肥大细胞数量的动态变化，可以作为观察肝纤维化变化的一项辅助指标；肝脏羟脯氨酸的浓度变化可以作为肝纤维化的辅助诊断及应用于相关实验的研究。

Materials and methods: The lung preparation of 6 SARS death patient (died in 9,14,20,29,33,38d) and 6 macaque model (killed in 7,12,14,14, 32, 35d)were objects. Pathological changes, collagen fibers, lattice fibers, elastic fibers, collagen I and III in lungs and fine structure changes were studied by routine H.E dyeing, trigeminy dyeing, trinitrophenol- sirius red staining and polarization microscope, electron microscope and image analysis. Expression of Vimentin、 TGFβ_1、 TNF α、 IL-1β and MMP-2 were detected by immunohistochemistry.Results:1. Pathological changes of SARS death patient.

材料与方法：以6例SARS死亡患者(分别于发病后9、14、20、29、33、38d死亡)和6只猕猴实验模型(分别于染毒后7、12、14、14、32、35d活杀取材)肺标本为对象，应用H.E染色、三联染色、苦味酸-天狼猩红-偏振光法、电镜和图像分析等技术，对比性观察SARS肺组织病理变化和纤维化的病理过程、胶原纤维、网状纤维和弹力纤维的变化特点、Ⅰ型与Ⅲ型胶原纤维的数量和分布规律，旨在探讨SARS肺纤维化的病变经历过程及特点；利用免疫组织化学和形态计量学技术检测SARS死亡患者肺脏的Vimentin、TGFβ_1、TNFα、IL-1β和MMP-2等与炎症反应和纤维化相关活性因子，探讨其发病机制。

These data suggest that gold nanoparticles may bind to TGF-β1 and block its downstream signaling pathway and that Tα1 may reduce inflammatory responses, resulting in reducing the expression of TGF-β1. These activities may have contributed to their anti-fibrotic effects.

因此我们推测金奈米在四氯化碳诱发小鼠肝纤维化的状态下，具有抗纤维化的效果，可能是透过与TGF-β1结合而阻断其下游讯息传递；而Tα1在四氯化碳诱发小鼠肝纤维化的状态下，可能是透过降低发炎反应而减少TGF-β1的表现来达到抗纤维化的效果。

Yi TAI Compounded Medication "we used bases on the basic theory of TCM,set up "The treatment of invigoratmg spleen and promoting blood by regulating qi",target defiency in origin and excess in superficiality TCM syndrome nature,and take experiments;our research injecting L-Arg into abdomen to induce Spleeh-asthenis rat model,it is a new model which combine diseases and syndromes;immunohistochemic 、 optical mirror and biochemistry value number index number are used to detect the expression of related constrain factor TGF-β_1 mRNA、α-SMA when textnre fabrosis occurs in pancreatic,as nell as significance and relation of hydroxyproline in the process of pancreatic fibrosis,meanwhile observe the disturbace which "Yi TAI Compounded Medication makes,revel the anti-fibrosis mechanism from organization form and molecular level.

本研究采用L—精氨酸分次腹腔注射诱导脾虚型慢性胰腺炎大鼠模型，是一种病证结合的新模型；用免疫组化、光镜等技术和生化指标检测CP时胰实质纤维化的相关调控因素TGF-β_1、α-SMA的表达和血清中羟脯氨酸在胰腺纤维化过程中的作用及相互关系，同时观察了&胰泰复方&对其干预机理，从组织形态学和分子水平揭示了该方抗纤维化的作用机制。

与纤维化的相关的网络解释 [注：此内容来源于网络，仅供参考]

cystic fibrosis：囊纤维化

胞囊纤维化(cystic fibrosis)基因是在白人中常看到的基因(2%的白人有这个基因),这种引起疾病缩短生命的基因为什么遗留下来还有争议,但是,证据显示胞囊纤维化基因有抗结核病的功效,欧洲十七世纪的结核病流行,结果,相当多的有胞囊纤维化基因的人生存下来了.

acute exacerbation of idiopathic pulmonary fibrosis：特发性肺纤维化的急性加重

5 acute exacerbation 急性加重 | 6 acute exacerbation of idiopathic pulmonary fibrosis 特发性肺纤维化的急性加重 | 7 acute lung injury 急性肺损伤

fibrosis：纤维化

纤维化(fibrosis)是某些慢性疾病发展到终末期的共同病理过程,其后果是组织损伤或脏器功能衰竭,因而及早阻止甚至逆转纤维化进程对慢性疾病的防治具有重大意义.

fibrosis：肝纤维化

肝纤维化(fibrosis)指肝脏内以胶原为主的纤维结缔组织的过度沉积,是由于胶原纤维等细胞外基质合成增加和降解不足所致,是多种慢性肝病的一共同病理过程.

hepatic fibrosis：肝纤维化

肝纤维化(hepatic fibrosis)是指肝脏内弥漫性细胞外基质(特别是胶原)过度沉积. 它不是一个独立的疾病,而是许多慢性肝脏疾病均可引起肝纤维化,其病因大致可分为感染性,先天性代谢缺陷及化学代谢缺陷及自身免疫性肝炎、原发性肝汁性肝硬化和原发性硬化性胆管炎等.

myocardial fibrosis：心肌纤维化

心肌纤维化(myocardial fibrosis)主要是由于心肌成纤维细胞(cardiac fibroblast, CFb)增殖和胶原纤维蛋白基因的过量表达、分泌和堆积的结果[1]. 现认为其与心律失常、心功能障碍甚至心脏性猝死密切相关,预防和逆转上述改变是抗心肌纤维化、阻断疾病进一步发展的重要措施.

pipestem fibrosis：干线型纤维化

在重度感染患者,门脉周围出现广泛的纤维化,肝切面上,围绕在门静脉周围长而白色的纤维束从不同角度插入肝内,称干线型纤维化(pipestem fibrosis),是晚期血吸虫病特征性病变.

fibrose：纤维化

fibroin 丝蛋白 | fibrose 纤维化 | fibrous 纤维质的;纤维状的

fibrotic：纤维化的 (形)

fibrositis 纤维组织炎 (名) | fibrotic 纤维化的 (形) | fibrous 纤维的; 纤维构成的; 纤维状的 (形)

Glycosylation in Cystic Fibrosis：囊肿纤维化中的糖基化

Giycosylation, Congenital Disorders of糖基化, 先天性紊乱 | Glycosylation in Cystic Fibrosis囊肿纤维化中的糖基化 | Phospholipid Metabolism in Mammals哺乳动物中的磷脂代谢