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Objective To investigate the clinical features, causes of blindness and diagnosis of Vogt Koyanagi Harada syndrome Methods The data of 157 patients with VKH syndrome were reviewed and analyzed Patients were carefully examined with slit lamp, ophthalmoscope, three mirror lens, fundus fluorescein angiography, indocyanine green angiography and HLA typing Results Headache was noted in 73 5% of these patients Simultaneous involvement of both eyes occurred in 80 8% of these patients Chroiditis,papilledema and edema of the retina adjacent to the optic nerve were noted in 100% of these patients in the posterior uveitis stage, whereas recurrent granulomatous anterior uveitis (98 4%),"sunset glow" fundus (95 8%) and Dalen Fuchs nodules (71 2%) were the common ocular findings in the recurrent anterior uveitis stage The common causes of blindness were papillitis, exudative retinal detachment and complicated cataract in the posterior uveitis stage, anterior uveal involvement stage and its recurrent stage Poliosis (36 3%) and alopecia (35 0%) were the most common extraocular findings Early irregular patches of fluorescence, followed by localized hyperfluorescent spots were the typical findings of FFA Dilation of choroidal vessels and leakage of ICG from the choroidal vessels were the common ICGA findings The prevalence of HLA DR4 and HLA DRw53 in patients (54 9% and 71 8% respectively) was significantly higher than that in controls (14 7% and 38 2% respectively) Conclusions VKH syndrome is characterized by chroiditis, papillitis or neuroretinitis in the posterior uveitis stage, followed by a generalized uveitis with a typical recurrent granulomatous anterior uveitis Extraocular findings and relevant examinations including FFA, ICGA and HLA typing are helpful to the diagnosis of VKH syndrome
目的探讨Vogt-Koyanagi-Harada综合征患者的临床特征、盲目原因及诊断等有关问题。方法对在1996年1月至2000年12月间就诊资料完整的157例VKH综合征患者进行回顾性分析,并对裂隙灯、眼底镜、三面镜、荧光素眼底血管造影(fundus fluorescein angiography,FFA)、吲哚青绿血管造影(indocyanine green angiography,ICGA)及人类白细胞抗原分型等检查结果进行分析。结果 VKH综合征最常见的前驱症状为头痛(102例,73.5%),双眼同时患病118例(80.8%);后葡萄膜炎期眼部主要表现为脉络膜炎、视乳头及附近视网膜水肿(100.0%);前葡萄膜炎反复发作期眼部表现为复发性肉芽肿性前葡萄膜炎(128例,98.4%)、晚霞状眼底改变(95.8%)及Dalen-Fuchs结节(71.2%);后葡萄膜炎期、前葡萄膜受累期及前葡萄膜炎反复发作期导致盲目的主要原因分别为视乳头炎、视网膜脱离及并发性白内障;毛发变白(36.3%)及脱发(35.0%)是最常见的眼外表现;炎症活动期FFA典型表现为斑驳状高荧光,ICGA发现脉络膜血管扩张、通透性增高等改变;VKH综合征患者HLA-DR4及HLA-DRw53的阳性率(54.9%及71.8%)显著高于正常对照组(14.7%及38.2%)。结论 VKH综合征患者在后葡萄膜炎期眼部典型表现为双侧脉络膜炎、视乳头炎或神经视网膜炎,随后出现以反复发作的肉芽肿性前葡萄膜炎为特征的全葡萄膜炎。眼外症状及相关的辅助检查包括FFA、ICGA 及HLA分型等有助于VKH综合征的诊断。
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The notable proliferation was not observed by eyes in the local of injection. The infiltration of inflammation cells and mild proliferation of fibrocyte around dura mater was observed by HE stained in 4 and 8 weeks after injection. Infiltration and exudation of inflammation cells was observed by HE stained in epidural nerve root. Compared with group A, no changes of group B, C and D were observed under specific stained. Proliferation of type Ⅱ collagen fibers around dura mater was seen under immunohistochemical stained in 4 and 8 weeks after injection. There is no significant demyelination changes under LFB stained. The thickness and shape of the myelin sheath in epidural nerve root was not regular under transmission electronic microscopy in 4 and 8 weeks after injection. Fibroblast was also seen there. In nerve endometrium, macrophage could be seen under TEM, myelinated nerve fiber changed significantly, but nonmyelinated nerve fiber changed mildly. When 8 weeks, the changes of group D is smaller than the group B and C.
给药局部肉眼观察未见明显的纤维组织增生;HE染色可见B、C、D三组给药后四周及八周时硬膜内外均有炎细胞浸润,纤维细胞轻度增生,硬膜外神经根内有炎细胞浸润及炎性渗出;特殊染色B、C、D三组同A组相比未见有脊髓及神经根的改变;免疫组化染色,给药后四周及八周时,硬膜内外均有Ⅱ型胶原纤维增生;固兰染色B、C、D三组未见有明显脱髓鞘改变,与A组相比无明显异常改变;电镜观察B、C、D三组在给药后的四周及八周时,表现为硬膜外神经根内髓鞘厚薄不一,形状不规则,可见成纤维细胞,神经内膜中可见有巨噬细胞;粗大的有髓神经纤维变化明显,无髓神经纤维受累较轻;八周时电镜下D组改变较B、C两组为轻。
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Objective:To evaluate the direction value of perimetry in diagnosing and curing the acute retrobulbar neuritis.
目的:研究视野检查在急性球后视野神经炎诊治中的指导价值。
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It is not a popular method because, despite utmost care, it is possible to injure the tibial essels and nere. Neertheless, it may be useful for fracture-dislocations of the talus, other traumatic lesions of the ankle joint, and osteochondritis dissecans of the talus.
采用此入路即使极为小心,仍有可能损伤胫后血管及神经,因此该切口并不常用,但可能用于距骨骨折脱位、踝关节的一些其他损伤及距骨的剥脱性骨软骨炎。
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EPO was considered to be excreted only by the kidney and responsible for the proliferation, maturation, and differentiation of the precursors of the erythroid cell line incretory hormone.
在大鼠脑损伤模型中,EPO对抗损伤后炎症反应,并起到神经保护作用;在实验性自身免疫性脑脊髓炎大鼠模型和大鼠大脑中动脉梗塞模型的研究中发现,EPO可明显抑制促炎性细胞因子和趋化因子的产生,进而减轻炎症反应。
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Methods 72 mimic cervical radiculitis Wistar rats were divided into 4 groups randomly:moderate dose group of JZ-I,high dose group of JZ-I,Jingfukang group and control group.JZ-I of moderate dose,JZ-I of high dose,Jingfukang and water were given to the rats seperately.PGE2 was determinated by radioimmunoassay at 3,7,14 days after animal models had been made.
将72只模拟颈神经根炎Wistar大鼠随机分为四组:颈椎Ⅰ号中剂量组、颈椎Ⅰ号高剂量组、颈复康组及空白对照组,分别给予颈椎Ⅰ号中剂量、高剂量、颈复康及凉开水,于造模后3天、7天、14天,取血浆进行PGE2含量的放射免疫测定。
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Methods 132 neurosurgical patients undergoing selective subfrontal craniotomy without the pain of the incision of scalp were involved. The onset, severity, and characters of the neuralgia were recorded.
132例择期行冠状切口经额下入路的神经外科患者,排除切口局部疼痛后记录神经痛的发生时间、程度和性质;所有拟诊为术后神经痛的患者首先应用非甾体类消炎镇痛药物口服及脱水治疗,对经药物治疗后疼痛视觉模拟评分仍高于7分的患者行类固醇激素神经阻滞疗法。
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Dachengqi decoction can improve the gastrointestinal motility in MODS and the mechanism may be related to its effects on the distribution and the connection of the network of cholinergic nerve-ICC-smooth muscle of deep muscular plexuses in the intestine of rats with MODS.
本实验以细菌性腹膜炎致MODS模型大鼠为研究对象,观察MODS模型和大承气汤治疗后小肠深部肌间神经丛神经-ICC-平滑肌网络形态学变化,探讨大承气汤治疗MODS胃肠运动障碍的机制。
- 更多网络解释与神经炎后的相关的网络解释 [注:此内容来源于网络,仅供参考]
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coxalgia:痛
(五)髂痛(coxalgia)髂关节病变时,疼痛位于腹股沟区,或大腿内侧,步行后加重,多见于一过性滑膜炎,髋关节结核及Legg-Perthes氏病;源于腰、骶神经根部的病变,疼痛常感应至臀部,或自臀部向大腿放射,腰部活动时加剧.
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multiple sclerosis:多发性硬化症
(三)多发性硬化症(multiple sclerosis)是一种青、壮年时期的中枢神经系统脱髓鞘疾病,其特点为病灶播散在病程中常有缓解和复发的反复出现. 病损部位的不同,临床表现可多种多样. 常有精神症状的言语障碍. 颅神经功能障碍以球后神经炎为首发症状多见.
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retrobulbar neuritis:球后视神经炎
球后视神经炎(Retrobulbar neuritis)一般分为急性和慢性两类,以后者较多见. 由于视神经受侵犯的部位不同,球后视神经为可分许多不同类型:病变最常侵犯视盘黄斑束纤维,因该束纤维在球后眶内段视神经中央部分,故又名轴性神经炎;当病变由神经鞘膜侵犯视神
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neuromyelitis optica:视神经脊髓炎
(一)视神经脊髓炎(neuromyelitis optica)是合并有视神经和脊髓的脱髓鞘疾病. 20~40岁好发,脊髓与神经症状常先后(或后先)出现,脊髓病变胸段最多,多呈横贯性病征,此外可有阵发性剧烈抽搐,或有烧灼样的局部痛性强直性痉挛发作. 视神经为视乳头炎或球后视神经炎,
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retrocardiac:心后的
retrobulbarneuritis 球后神经炎 球后视神经炎 | retrocardiac 心后的 | retrocatcanealbursitis 跟后粘液囊炎