激动性

基本解释 (translations)

excitability

与激动性相关的网络例句 [注：此内容来源于网络，仅供参考]

The accentuation of vascular sensitivity to α2-AR agonist may be one of the mechanisms of abdominal aorta hyperreactivity.

对α2-AR之激动剂敏感性上调可能是高位SCT大鼠腹主动脉高反应性的原因，而α1-AR在血管高反应性中不起作用。

Binding of death ligand such as FasL, or agonistic antibodies to their cognate receptors induces apoptosis.

死亡受体的激动性抗体或自然配体与受体的结合能够诱导细胞凋亡。

Study on molecular characters of atagonist indicated that neonicotinoids insecticides and the active pharmaceutical group displayed electro-negative and electro-positive, and study on the interaction between atagonist and nAChR at the complex of subunit of insect and subunit of mammalian indicated that the effect of basic aminoacid in D ring of binding location of ACh is very obvious, and the YXCC in C ring of binding location also attracted the attention too.

激动剂的分子特点研究表明，新烟碱类杀虫剂和ACh药效基团在静电性上分别显示负电性和正电性。用昆虫亚基和脊椎动物亚基组成的杂合受体同激动剂相互作用的研究，主要集中在受体亚基上不同氨基酸残基与不同激动剂结合电生理效应的特点上。

The combustibility of our commercial life style.

商业生活方式的易激动性。

Its like there is this committee out there trying to remind us about the combustibility of our commercial life style.

好像有那么个委员会在那儿试图提醒我们商业生活方式的易激动性。

Alteration in excitability and conductivity of a nerve or muscle during the passage of an electric current through it.

电紧张当电流通过时，某一神经或肌肉产生的易激动性和传导体的变化

In the present study, weclarify the capsaicin concentration dependency for developmentand maintenance of secondary mechanical allodynia and the roleof spinal opioid receptor like1 (ORL1) receptor and N -methyl-d-aspartatereceptor in the development and maintenance of secondary mechanicalallodynia induced by an intradermal capsaicin injection. Capsaicin50 L of 0.03% induced the most intense secondary mechanicalallodynia.

在这个实验中，作者研究皮内注射辣椒素与继发性机械性异常性疼痛的相关性和脊髓阿片受体相关1受体激动剂（ ORL1）和 N-甲基-D-天门冬氨酸受体在皮内注射引起的继发性机械性异常性疼痛的发生和维持中的作用。0.03%的辣椒素50uL 导致最强的异常性疼痛。

In this study, We typed the the gene of β〓-AR from genomic DNA of asthmatic patients and made the further analysis: The distributing condition of genetic polymorphisms at positions 16 and 27 in β〓 AR coding region and at position 19 in 5'Leader Cistron (5'LC) among southwest Chinese asthmatic population; The relationship between the each polymorphisms at the above three positions and the asthmatic phenotypes (FEV〓 or nocturnal asthma); The effect of each polymorphisms at the above three positions on bronchodilator responsiveness induced by β〓- agonists(initial bronchodilator response, pharmaco-dynamic); The relationship between the haplotypes of polymorphisms in the 5'LC or in positions 16, 27 of β〓AR coding block and asthmatic phenotypes or bronchodilator responsiveness induced by β〓-agonists.

实验通过对哮喘人群的β〓-AR基因进行分型，探讨：β〓-AR编码区16、27位点及5'前导肽(5'LeaderCistron，5'LC)19位点遗传多态性在中国西南地区哮喘人群中的分布情况；三个位点多态性与哮喘临床表现型的关系；三个位点多态性对β〓受体激动剂反应性(支气管舒张反应，舒张反应动力学)的影响；16、27位点及5'前导肽19位点遗传多态性单倍型与哮喘临床表现型及β〓受体激动剂反应性的关系。

The effects and mechanism of GABAergic neurons, NOergic neurons, opioid peptide and cyclic adenosine monophosphate in the nucleus reticularis thalami on sleep-wakefulness cycle of rats and the effects and mechanism of the 5-HTergic nerve fibers project from the nucleus raphes dorsalis to RT on sleep-wakefulness cycle of rats were investigated with the methods of brain stereotaxic, nucleus spile, microinjection and polysomngraphy.1. The effects of GABAergic neurons in RT on sleep-wakefulness cycle of rats1.1 Microinjection of 3-mercaptopropionic acid (3-MP, a kind of glutamate decarboxylase inhibitor) into RT. On the day of microinjection, sleep only decreased a litter. On the second day, sleep marked decreased and wakefulness marked increased. On the third and fourth day, sleep and wakefulness stages resumed to normal.1.2 Microinjection of gamma-amino butyric acid (GABA 1.0μg) into RT enhanced sleep and reduced wakefulness compared with control; while microinjection of L-glutamate (L-Glu, 0.2μg) decreased sleep and increased wakefulness; microinjection of bicuculline (BIC, 1.0μg), a GABAA receptor antagonist, enhanced wakefulness and reduced sleep; microinjection of baclofen (BAC, 1.0μg), GABAB receptor agonist, had the same effects as GABA.2. The effects of NOergic neurons in RT on sleep-wakefulness cycle of rats2.1 Microinjection of L-arginine (L-Arg, 0.5μg) into RT decreased sleep compared with control, but there were on statistaical difference between L-Arg group and control; while microinjection of sodium nitroprusside (SNP, 0.2μg), a NO donor into RT, sleep marked decreased and wakefulness marked increased. Microinjection of nitric oxide synthase inhibitor, N-nitro-L-arginine (L-NNA, 2.0μg) into RT enhanced sleep and reduced wakefulness.2.2 After simultaneous microinjection of L-NNA (2.0μg) and SNP (0.2μg) into RT, SNP abolished the sleep-promoting effect of L-NNA compared with L-NNA group; after simultaneous microinjection of L-NNA (2.0μg) and L-Arg(0.5μg) into RT, we found that L-NNA could not blocked the wakefulness-promoting effect of L-Arg.3. The effects of opioid peptide in RT on sleep-wakefulness cycle of rats3.1 Microinjection of morphine sulfate (MOR, 1.0μg) into RT increased wakefulness and decreased sleep compared with control; while microinjection of naloxone hydrochloride (NAL, 1.0μg), the antagonist of opiate receptors, into RT, enhanced sleep and reduced wakefulness.3.2 After simultaneous microinjection of MOR (1.0μg) and NAL (1.0μg) into RT, the wakefulness-promoting effect of MOR and the sleep-promoting effect of NAL were not observed compared with control.4. The effects of cAMP in RT on sleep-wakefulness cycle of rats Microinjection of cAMP (1.0μg) into RT increased sleep and decreased wakefulness compared with control; microinjection of methylene blue (MB,1.0μg) into RT enhanced sleep and reduced wakefulness compared with control.5. The effects of the 5-HTergic nerve fibers project from DRN to RT on sleep-wakefulness cycle of rats5.1 When L-Glu (0.2μg) was microinjected into DRN and normal sodium (NS,1.0μg) was microinjected into bilateral RT. We found that sleep was decreased and wakefulness was increased compared with control; when L-Glu (0.2μg) was microinjected into DRN and methysergide (MS,1.0μg), a non-selective 5-HT antagonist, was microinjected into bilateral RT, We found that sleep was enhanced and wakefulness was reduced compared with L-Glu group.5.2 When p-chlorophenylalanine (PCPA, 10μg) was microinjected into DRN and NS (1.0μg) was microinjected into bilateral RT, We found that sleep was increased and wakefulness was decreased compared with control; microinjection of 5-hydroxytryptaphan (5-HTP, 1.0μg), which can convert to 5-HT by the enzyme tryptophane hydroxylase and enhance 5-HT into bilateral RT, could block the effect of microinjection of PCPA into DRN on sleep-wakefulness cycle.

本研究采用脑立体定位、核团插管、微量注射、多导睡眠描记等方法，研究丘脑网状核(nucleus reticularis thalami，RT)中γ-氨基丁酸(gamma-amino butyric acid ，GABA)能神经元、一氧化氮(nitrogen monoxidum，NO)能神经元、阿片肽类神经递质、环一磷酸腺苷(cyclic adenosine monophosphate，cAMP)及中缝背核(nucleus raphes dorsalis，DRN)至RT的5-羟色胺(5-hydroxytryptamine，5-HT)能神经纤维投射对大鼠睡眠-觉醒周期的影响及其作用机制。1 RT内GABA能神经元对大鼠睡眠-觉醒周期的影响1.1大鼠RT内微量注射GABA合成关键酶抑制剂3-巯基丙酸(3-MP，5μg)，注射当天睡眠时间略有减少，第二日睡眠时间显著减少，觉醒时间明显增多，第三、四日睡眠和觉醒时间逐渐恢复至正常。1.2大鼠RT内微量注射GABA受体激动剂GABA( 1.0μg)后，与生理盐水组比较，睡眠时间增加，觉醒时间减少；而RT内微量注射L-谷氨酸(glutamic acid， L-Glu， 0.2μg)后，睡眠时间减少，觉醒时间增加；RT内微量注射GABAA受体阻断剂荷包牡丹碱(bicuculline，BIC，1.0μg)后，睡眠时间减少，觉醒时间增加；RT内微量注射GABAB受体激动剂氯苯氨丁酸(baclofen，BAC，1.0μg)后，产生了与GABA相似的促睡眠效果。2 RT内NO能神经元对大鼠睡眠-觉醒周期的影响2.1大鼠RT内微量注射NO的前体L-精氨酸(L-Arg，0.5μg)后，与生理盐水组对比，睡眠时间略有减少，但无显著性意义；而RT内微量注射NO的供体硝普钠(Sodium Nitroprusside，SNP，0.2μg)后可明显增加觉醒时间，缩短睡眠时间；微量注射一氧化氮合酶抑制剂L-硝基精氨酸(L-arginine，L-NNA，2.0μg)后，引起睡眠时间增多，觉醒时间减少。2.2大鼠RT内同时微量注射L-NNA(2.0μg)和SNP(0.2μg)后与L-NNA组比较发现SNP逆转了L-NNA的促睡眠作用；RT内同时微量注射L-NNA(2.0μg)和L-Arg(0.5μg)后，与L-NNA(2.0μg)组比较发现L-Arg可以增加觉醒而缩短睡眠，其促觉醒作用未能被NOS的抑制剂L-NNA所逆转。3 RT内阿片肽对大鼠睡眠-觉醒周期的影响3.1大鼠RT内微量注射硫酸吗啡(morphine sulfate，MOR，1.0μg)后与生理盐水组对比，睡眠时间减少而觉醒时间增加； RT内微量注射阿片肽受体拮抗剂盐酸纳洛酮(naloxone hydrochloride，NAL，1.0μg)后与生理盐水组比较，睡眠时间增加而觉醒时间减少。3.2大鼠RT内同时微量注射MOR(1.0μg)和NAL(1.0μg)后，与生理盐水组对比，原有的MOR促觉醒效果和NAL的促睡眠效果都没有表现。4 RT内环一磷酸腺苷信使对大鼠睡眠-觉醒周期的影响大鼠RT内微量注射cAMP(1.0μg)后与NS(1.0μg)组比较，睡眠时间增多而觉醒时间减少；RT内微量注射亚甲蓝(methylene blue，MB，1.0μg)后，与NS组比较，睡眠时间增多而觉醒时间减少。5中缝背核投射到丘脑网状核的5-羟色胺能神经纤维对大鼠睡眠-觉醒周期的影响5.1大鼠DRN内微量注射L-Glu(0.2μg)，同时在双侧RT内微量注射NS (1.0μg)后，与对照组(DRN和双侧RT注射NS， 0.2μg)比较，睡眠时间减少，觉醒时间增多；大鼠DRN内微量注射L-Glu(0.2μg)，同时在双侧RT内微量注射二甲基麦角新碱(methysergide， MS， 1.0μg )后，与对照组(DRN注射L-Glu 0.2μg，双侧RT注射NS 1.0μg)比较，睡眠时间增多，觉醒时间减少。5.2大鼠DRN内微量注射对氯苯丙氨酸(p-chlorophenylalanine，PCPA，10μg)，同时在双侧RT内微量注射NS (1.0μg)后，与对照组(DRN和双侧RT注射NS， 1.0μg)比较，睡眠时间增多，觉醒时间减少；大鼠DRN内微量注射PCPA(10μg)，产生睡眠增多效应后，在双侧RT内微量注射5-羟色胺酸(5-hydroxytryptaphan ， 5-HTP， 1.0μg )后，与对照组(DRN注射PCPA 10μg，双侧RT注射NS 1.0μg)比较，睡眠时间减少，觉醒时间增多。

The results showed that (1) all the arteries tested had tachyphylaxis to peptidergic agonists;(2) the desensitization of the arteries tested to catecholamines was uneasy except BA;(3) the desensitizations to AⅡ, AVP and PE were homologous;(4) the endothelium-EDRF -cGMP pathway had no contribution to the tachyphylaxis of PA to AⅡ and AVP;(5) membrane receptor cycling (internaliation and re-insertion) contributed only in part to homologous desensitization;(6) there was no change in the function of voltage-dependent Ca〓 channel during desensitization to AⅡ and AVP;(7) some changes in G protein occurred during homologous desensitization;(8) the most surprising finding was that the caudal arterial smooth muscle of stroke-prone spontaneously hypertensive rat showed tachyphylaxis to α〓-adrenoceptor agonist PE, while the tachyphylaxis of pulmonary artery of SHR was not changed compared with that of Wistar rat.

脱敏是消除效应的一种有效方式。因此，研究不同血管对不同激动剂脱敏的差异及阐明脱敏的机制，有助于阐明血管活动个性化的机制。研究表明：血管对肽类激动剂的脱敏方式为快速脱敏，而对儿茶酚胺类激动剂不易脱敏；血管对肽类激动剂和儿茶酚胺类激动剂表现为同源脱敏；内皮-NO-cGMP通路不参与肺动脉对AⅡ和AVP的快速脱敏；用PAO抑制膜受体的内在化只能短暂抑制脱敏的发展，提示用膜受体数目的下调说不能完全解释同源脱敏；血管对AⅡ和AVP脱敏后VSMC细胞膜电压依赖性钙通道功能无改变；CA对AVP脱敏后GTPγS的量-效曲线下移，说明有G蛋白的变化，但这种变化并非G蛋白的亲和性改变；SHRsp之CA平滑肌对AⅡ和AVP的快速脱敏并未减弱，但对PE却表现为快速脱敏，这是我们首次发现的一个非常有趣的现象。

与激动性相关的网络解释 [注：此内容来源于网络，仅供参考]

agitated depression：激动性抑郁症

agitated crowd 骚动的群众 | agitated depression 激动性抑郁症 | agitated mania 激动躁狂症

sinus arrhythmia：窦性心律失常

又名Weill-Marchesani综合征、中胚层发育异常营养障碍、先天性中胚层二形性 营养不良 综合征、Marchesani综合征、Marfan转化型综合征、短指-晶状体半脱位综合征、...窦性 心律失常 (sinus arrhythmia)指窦房结发生的激动不匀齐,

excitatory autacoid：激素

excitatory 兴奋性 | excitatory autacoid 激素 | excitatory conditioning 激动性条件反射

emotionalize：使激动

emotionality 情绪性 | emotionalize 使激动 | emotionally 在情绪上

emotionalize：使激动/使动情

emotionality /感动性/情绪性/ | emotionalize /使激动/使动情/ | emotionally /在情绪上/

inflammability：易激动性

inflamedeyelidsparched 眢 | inflammability 易激动性 | inflammation 怒火

rhythmicity：节律性

2、心脏特殊传导系统的自律(起搏)细胞,可在无外来刺激的条件下,通过其自身的内在变化而自动地、有节律地发放电激动,产生动作电位,引发心脏有节律的舒缩活动,推动血液循环的正常运行. 心脏这种固有的自动性(automaticity)和节律性(rhythmicity),合称"自动节律性",简称自律性.

concussive：给与冲击的/震荡性的

concussion | 激动, 冲击, 震荡 | concussive | 给与冲击的, 震荡性的 | concutient | 受到震荡性撞击的受到震荡的

excitatory：激动性,刺激的

兴奋药 excitant | 激动性,刺激的 excitatory | 激动 excitement

otitic brain abscess：耳原性脑脓肿

otional excitement 感情激动 | otitic brain abscess 耳原性脑脓肿 | otitic hydrocephalus 耳原性脑积水,中耳炎性脑积水