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Methods: 1 Ornidazole and Pefloxacin are divided to six levels, in order to measure the changes of antiblastic indexes of different proportions of Ornidazole and Pefloxacin against Pg, Fn, Pi, and Peptostreptococcus spp. Statistical test is used to seek the indistinctive ranges of antibacterial activities of Ornidazole and Pefloxacin against those four kinds of typical periodontal pathogens, and to find the suitable proportion.
1奥硝唑和培氟沙星各自分为6水平，测量两种药物不同比例水平混合后对牙龈卟啉单胞菌，具核梭杆菌，中间普氏菌，消化链球菌标准菌株的抑菌指标变化，通过统计检验找出奥硝唑和培氟沙星不同配伍抑菌指标的无差别比例范围，并找出合适比例。2检测两种药物以及其合适的比例对厌氧菌标准菌株和42株临床分离的非厌氧菌的MIC和MIC50。
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Results: The proportion of Gram-negative bacilli rose obviously, so did the opportunistic pathogen's and Yeasts detected rate. Most drug sensitive tests showed the drug-fast rate turned to be high. Escherichia coli, Salmonella and Citrobacter resistant and so on to fluoroquinolones was 57%~97%. These bacteria to imipenem showed excellent activity. Meticillin-resistant-staphylococcus resistant to ciprofloxacin, norfloxacin, clindamycin, tetracycline, erythromycin, cefazolin and ampicillin were 40.9%, 42.4%, 63.6%, 72.2%, 85.9%, 100.0% and 100.0%, respectively Streptococcus and Enterococcus resistant to major β-lactams-penicillin, aminoglycosides, macrolides, tetracyclines and sulfonamides were between 36.0% to 100.0%.
结果：革兰阴性杆菌比例显著升高，条件致病菌和酵母样真菌检出机会显著增多；药敏结果显示多数临床细菌对常用抗生素的耐药趋势在不断上升；大肠埃希菌、沙门菌和枸橼酸杆菌等革兰阴性杆菌对喹诺酮类药物的耐药率达57%~97%，亚胺培南则对阴性杆菌有较高的敏感覆盖率；耐甲氧西林葡萄球菌对环丙沙星、诺氟沙星、氯洁霉素、四环素、红霉素、头孢唑啉和氨苄西林的耐药率分别为40.9%、42.4%、63.6%、70.2%、85.9%、100.0%和100.0%；链球菌和肠球菌对多数β内酰胺类青霉素、氨基糖苷类、大环内酯类、四环素类以及磺胺类药物均呈高度耐药，耐药率在36%~100%。
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To Dec. 2003 years in Yuxi city People's Hospital. RESULTS: The proportion of G－ bacilli were much. The opportunistic pathogen's and Yeasts detected rate rose obviously. Most drug sensitive tests showed the drug-fast rate turned to be high. Escherichia coli, Salmonella and Klebsiella and so on to fluoroquinolones was 50～97.7%. These bacteria to imipenem showed excellent activity. MRS resistant to ciprofloxacin, norfloxacin, clindamycin, tetracycline, erythromycin, gentamycin, trimeth/sulfa and cefazolin were above 50%. Streptococcus resistant to major β-lactams-penicillin, aminoglycosides, macrolides, tetracyclines and sulfonomides were highness.
结果：G－杆菌比例居多，条件致病菌和酵母样真菌检出机会显著增高；药敏结果显示多数临床细菌对常用抗生素的耐药趋势在不断上升；大肠埃希菌、沙门菌和克雷伯菌等G－杆菌对喹诺酮类药物的耐药率在50％～97.7％，亚胺培南则对阴性杆菌有较高的敏感覆盖率；耐甲氧西林葡萄球菌对环丙沙星、诺氟沙星、氯洁霉素、四环素、红霉素、庆大霉素、复方新诺明和头孢唑啉的耐药率均在50％以上，链球菌对多数β内酰胺类青霉素、氨基糖苷类、大环内酯类、四环素类以及磺胺类药物呈高度耐药。
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Ciardiello and colleagues tested ZD1839, a quinazoline derivative, in combination with cytotoxic agents that had differing mechanisms of action (cisplatin, carboplatin, oxaliplatin, paclitaxel, Taxotere, doxorubicin, etoposide, topotecan, and tomudex).
Ciardiello及其同事试验了将一种喹唑啉衍生物ZD1839与作用机制不同的细胞毒素药物（顺铂、卡铂、奥沙利铂、紫杉醇、泰索帝、阿霉素、依托泊甙、拓扑特肯等）合用。
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In the process, 2, 4-difluoroaniline is used to carry out ammoniated reaction. Then through a series of similar reactions, the important intermediate of temafloxacin, which is called 7-chloro-6-fluoro-1-(2, 4-difluorophenyl)-1, 4-dihydro-4-oxo-3-quinoline acid, is gained.
与环丙沙星和二氟沙星类似，用2，4-二氟苯胺进行胺化反应，再进行一系列类似的反应，制得合成替马沙星的关键中间体7-氯-6-氟-1-（2，4-二氟苯基）-1，4-二氢-4-氧代喹啉-3-羧酸。
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morpholine salicylate：水杨吗啉[解热镇痛药]
Morphine 吗啡[镇痛药] | Morpholine Salicylate 水杨吗啉[解热镇痛药] | Mosapramine 莫沙帕明[抗抑郁药]
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quinazoline：喹唑啉
易瑞沙是喹唑啉(quinazoline)类表皮生长因子受体(EG-FR)酪氨酸激酶抑制剂,通过竞争性结合ATP来抑制EGFR细胞内的酪氨酸激酶域的自磷酸化作用,阻断了下游信号的传递,从而达到抑制肿瘤血管生成、细胞增殖、侵袭以及转移,促进细胞凋亡的治疗作用,
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sulfapyridine：磺胺吡啶[磺胺类药]
Sulfapyrazole 磺胺吡唑[磺胺类药] | Sulfapyridine 磺胺吡啶[磺胺类药] | Sulfaquinoxaline 磺胺喹沙啉[磺胺类药]
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sulfaquinoxaline：磺胺喹沙啉
磺胺柯定 Sulfachrysoidine | 磺胺喹沙啉 Sulfaquinoxaline | 磺胺林 Sulfalene;Sulfametopyrazine
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sulfaquinoxaline：磺胺喹沙啉[磺胺类药]
Sulfapyridine 磺胺吡啶[磺胺类药] | Sulfaquinoxaline 磺胺喹沙啉[磺胺类药] | Sulfarside 磺胺苯胂[抗感染药]
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thalline：沙啉
texture 构造组织 | thalline 沙啉 | thallium 铊
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Norfloxacin Nicotinic：烟酸诺氟沙星
4-二氢-7-(1-哌嗪基)-3-喹啉羧酸烟酸盐CAS N甲磺酸培氟沙星 70458-95-6 名称:甲磺酸培氟沙星(Pefloxacini Mesylas)化学名称:1-乙基-6-氟-1,4-二氢-7-(4-甲基-1-哌嗪)-4-氧代-3-喹啉羧酸的甲基磺烟酸诺氟沙星 118803-81-9 名称:烟酸诺氟沙星(Norfloxacin Nicotinic) 化学名:1-乙基-6-氟-4氧代-1,
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benzoquinhydrone; quinhydrone：对苯醌合对苯二酚
苯并吡[口+井];喹[口+咢]啉 benzopyrazine; quinoxaline | 对苯醌合对苯二酚 benzoquinhydrone; quinhydrone | 苯甲酰磺酰亚胺;糖精;沙卡林 benzosulfimide; saccharin