构象的

基本解释 (translations)

conformational

与构象的相关的网络例句 [注：此内容来源于网络，仅供参考]

Single crystal of Arginine dichloride dihydrate was studide by x-ray diffraction expriments in emphasis of main influence factors of arginine conformational variation,and was also compared with its other conformations in the existence of different anions.

以X光衍射实验对二水合氯酸的晶体结构进行了研究，重点讨论了影响精氨酸构象变化的主要因素并比较了在不同阴离子存在条件下精氨酸构象的变化情况。

According to the variations of the mean square deviation of the structures in MD trajectories relative to the initial structures, the false structures can be excluded.(2) In order to achieve the binding mode, the docking simulations were performed between glutathione and different isomers of 99mTc-HMPAO with the package of AutoDock.

以两种蛋白质复合物为例，对其候选结构进行MD模拟，根据MD轨迹中构象相对于初始北京工业大学工学硕士学位论文摘要一构象的平方平均偏差随时间的变化来辅助打分函数排除错误构象，得到了较好的结果。

The reason of that the extended structures always preponderant is thedegree of freedom of the extended is greater.

同时，在各种情况下伸展构象都占优势的主要原因在于伸展构象的分子运动自由度比较大。

The influencing factors that glutathione molecular umbrella penetrates lipid bilayers with the shielded conformation were analyzed with VolSurf parameters. The results show that the major influencing factors are smaller amphiphilic moment and larger molecular rugosity of the shielded conformation, which are independent of definite hydrophobic regions of the conformation.

利用VolSurf参数分析了分子伞以屏蔽构象穿透磷脂双分子层的影响因素，结果表明屏蔽构象较小的两亲矩及较大的分子褶皱程度是其能够穿透细胞膜的主要影响因素，与构象的绝对疏水区域无关。

For the protein side chain,the band at 1 368 cm-1 assigned to the "buried" tryptophan shifted to 1 365 cm-1 of the "exposed" and the relative intensity reduced 59%. The relative intensity of 635 cm-1 assigned to the gauche conformation of the C—S decrased 15% and the band at 725 cm-1 increased 58%.These indicate that the structure of the protein changed in the diabetic serum.The relative intensity at 1 449 cm-1 assigned to the lipids characteristic increased 58%.The relative intensity of the glucide characteristic at 1 331,1 099 and 740 cm-1 increased 35%,100% and 62%,respectively.

蛋白质侧链色氨酸吲哚环&埋藏式&的谱线1 368 cm-1位移到&暴露式&的1 365 cm-1，且相对强度减少了59%；侧链C—S键的扭曲构象的谱线635 cm-1相对强度减少了15%，而反式构象的谱线725 cm-1增加了58%，说明C—S键的扭曲构象部分转变为反式构象，表明糖尿病人血清中蛋白质的有序结构发生变化；类脂物特征峰1 449 cm-1相对强度增加了58%，与糖类有关的特征峰谱线1 331，1 099和740 cm-1相对强度分别增加了35%，100％和62%，从而表明糖尿病人血清中与脂类和糖蛋白有关的物质含量增加。

In chapter 2 of this dissertation, a highly efficient synthesis of the title compound: 1-methyl-2, 3, 3a, 4, 5, 9b-hexahydro-1H-pyrrolo [3, 2-h] isoquinoline (157), a conformationally constrained nicotine analog, has been accomplished in only seven steps starting from commercially available 3-bromopyridine.

在第二章中，我们对具有刚性构象的尼古丁类似物的合成进行了研究。医学研究表明，尼古丁及其类似物对许多神经系统类疾病具有很好的治疗效果，而且药理活性与分子的构象有着非常密切的关系，许多具有刚性构象的分子有着很强的药理活性。

The results show that both conformations of prolyl peptide bond are not easy to transit from each other supporting the opinion that both of the BPP's bio-characters are from its conformations separately. And the function of BPP may not lie on a conformation. The other peptide bond conformations also have influence.

结果表明，脯氨酸肽键构象不易发生互变，无论哪种构象均不存在向另一种构象转变的趋势，从侧面支持了BPP具有的两种稳定的生物学作用是来自于肽键的不同构象的观点，而且BPP的生物学作用可能也不是取决于某一个肽键构象，其它脯氨酸肽键构象对其活性也存在影响。

NodD binds to and bends target promoters through anchoring two tandem and individual specific DNA sites. NodD functions as a tetramer, which has a V-shaped main body. Tetrameric NodD is to change its own conformation rather than its oligomeric forms in response to small signal molecules. The specific interaction between each NodD DNA-binding domain and each specific DNA site does not alter itself in spite of naringenin induction, and the induced conformational change is transferred from protein to DNA. Only the DNA conformation incited by induced NodD is competent for RNA polymerase to form the transcriptional open complex. It cannot be excluded that NodD may have protein-to-protein contacts with RNA polymerase, and that the NodD conformational change may also directly contribute to the transcriptional open complex formation. However, the NodD conformational change itself cannot serve as the determinant of the transcriptional molecular switch.

通过研究，我们提出了初步的NodD操纵子激活模型：第一，四聚体是NodD蛋白的功能单位，它通过铆钉两个串联的相对独立的DNA靶位点结合被诱导的启动子；第二，小分子配基的结合是改变NodD四聚体的构象而不是引发不同形式的寡聚体，在我们的模型中，NodD四聚体缩小其V形主体的弯折角，进而缩短其DNA结合功能域的间距；第三，小分子信号的诱导并没有改变NodD的DNA结合域和其DNA靶位点的相互作用，NodD的构象改变由蛋白质经其双铆钉位点传递给DNA；第四，只有诱导状态的NodD激发的DNA构象才能有效地使RNA聚合酶形成转录开放复合物；第五，不排除NodD与RNA聚合酶可能有直接的相互接触位点，不排除NodD构象的改变可能直接有利于RNA聚合酶形成转录开放复合物，但是我们认为NodD构象改变本身不是充当转录激活开关的决定因素。

The active conformation of protoporphyrinogen IX (substrate of protoporphyrinogen oxidase) has been established using the Distance Comparisons method. In this paper, four different conformational molecules of Protogen IX and crystal molecule of diphenylethers are analyzed by comparing their geometry parameters. The results show the lower energy active conformation from the DISCO model is more reasonable.

我们曾利用距离比较法确定了原卟啉原氧化酶的底物—原卟啉原IX的活性构象，本文从构象分析的角度对4种不同构象的原卟啉原IX分子与二苯醚类分子的晶体学构象进行了几何参数的比较和分析，结果进一步证实了距离比较法所确定的活性构象更为可靠。

In the reasonable drug molecular design,analyzing the conformations of the substrate without three-dimension structure and confirming its active conformation are very important to illustrate the spatial shape and active site of target enzyme. The active conformation of protoporphyrinogen IX substrate of protoporphyrinogen oxidase has been established using the Distance Comparisons DISCO method. In this paper, four different conformational molecules of Protogen IX and crystal molecule of diphenylethersAF are analyzed by comparing their geometry parameters. The results show the lower energy active conformation from the DISCO model is more reasonable.

在合理药物设计方法中，当靶标酶的三维结构未知时，对其底物进行构象分析，特别是确定其活性构象，对阐明靶标酶活性中心的空间形状和作用位点具有十分重要的意义我们曾利用距离比较法确定了原卟啉原氧化酶的底物—原卟啉原IX的活性构象，本文从构象分析的角度对4种不同构象的原卟啉原IX分子与二苯醚类分子的晶体学构象进行了几何参数的比较和分析，结果进一步证实了距离比较法所确定的活性构象更为可靠

与构象的相关的网络解释 [注：此内容来源于网络，仅供参考]

conformation：构象

名称 构象(conformation) 解释 指一个分子中,不改变共价键结构,仅单键周围的原子放置所产生的空间排布. 一种构象改变为另一种构象时,不要求共价键的断裂和重新形成. 构象改变不会改变分子的光学活性. 指一个分子中,不改变共价键结构,

conformation：空间构象

而抗体对抗原的识别则表现为对抗原肽卷曲折叠后形成的特有的空间构象(conformation)的识别,当构象因蛋白变性而改变以后,其与特异抗体结合的特性也会发生改变,而TCR可识别抗原的点突变和序列差异,这点对肿瘤免疫研究来说非常重要.

eclipsed conformation：重叠式构象

构型和构象立体异构(stereo isomery) 分子式和结构式均相同,但立体结构(分子中各原子在空间排列方式)不同而产生的异构.包括--构象异构(conformation isomery)和重叠式构象(eclipsed conformation) 两甲基上的氢原子正处于相互对映的位置,

Conformer：构象子,构象异构体

confluent monolayer cells (汇合)成片的单层细胞,铺满的单层细胞 | conformer 构象子,构象异构体 | congelation 冻凝(作用)

D.H. R. BartonO. Hassel：英国挪威发展了构象分析概念及其在化学中的应用

1968 L. Onsager美国不可逆过程热力学研究 | 1969 D.H. R. BartonO. Hassel英国挪威发展了构象分析概念及其在化学中的应用 | 1970 L. F. Leloir阿根廷从糖的生物合成中发现了糖核苷酸的作用

D. H. R. Barton O. Hassel：英国 挪威 发展了构象分析概念及其在化学中的应用

1968 L. Onsager 美国 不可逆过程热力学研究 | 1969 D. H. R. Barton O. Hassel 英国 挪威 发展了构象分析概念及其在化学中的应用 | 1970 L. F. Leloir 阿根廷 从糖的生物合成中发现了糖核苷酸的作用

allosteric：变构(象)的

allose 阿洛糖(一种葡萄糖异橫体 ) | allosteric 变构(象)的 | allosteric enzyme 变构(象)酶

allosteric transition：别构转换[由别构剂所引起的蛋白质构象变化]

allosteric site 别构部位 | allosteric transition 别构转换[由别构剂所引起的蛋白质构象变化] | allosterism 别构,变构

Conformational：构象的

conformational isomer || 构象异构体 | conformational || 构象的 | conforming element || 相容元(素)

Conformational：构象的,结构的

gully小峡谷;水沟, 沟渠 | conformational 构象的,结构的 | contact 接触