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D. N big mouse model was successfully made by adopting single side kidney cutting with induction, then by 24 week continuos observation on the change of various values of kidney and function, through testing of immunity florescence, electro-scope and optical scope, what we can see from model group is that typical kidney small cell got hardened by knot, and discarded, and dead, also small tube withered, small cell of on base film got thick, cell capsule wall was fibred, and base film got double layered.
实验研究采用单侧肾切除加以链脲佐菌素诱导,成功地复制出糖尿病肾病大鼠模型,对其肾脏结构和功能的改变各项指标,连续进行24周动态观察,并进行免疫荧光、电镜、光镜检测,结果表明:糖尿病肾病模型组可见典型的肾小球节段硬化、废弃、坏死,有大量蛋白管型,肾小球管糖元空泡沉积及脂肪滴,肾小管萎缩,肾小球基底膜明显增厚,球囊壁纤维化,基底膜双层化,有一例结核性肉芽组织及钙化等病理变化。