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But whether the compound composed of them has suppressive effect on absence - like seizures of genetic tremor rats hasnt been reported. Furthermore, the animal models of investigating antiepileptic drugs were mostly induced by chemoconvulant or electrical stimulation. Since genetic factor is more primary in clinical epileptic patients, we used tremor rats fetched in from Japan as experimental animal models. We implanted electrodes in cortical and hippocampus of tremor rats and then recorded the electroencephalograms to observe effects of the traditional Chinese medicinal compound composed of Scolopendra, Bombyx Batryticatus, Uncaria and Arisacma Consanguineum on absence - like seizures in tremor rats.
而且以往多以化学致痫剂或电刺激等方法造模进行抗癫痫药物的研究，但在临床的癫痫患者中遗传因素占有相当大的比例，所以本实验应用了从日本引进的具有遗传性癫痫小发作的震颤大鼠作为实验动物模型，通过在震颤大鼠脑皮质和海马慢性安插电极后进行脑电图的记录，观察以蜈蚣、僵蚕、钩藤、制南星四味药为主的复方中药制剂对震颤大鼠癫痫小发作的抑制作用。
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Recently, along with the related research on calcium channels, the function of voltage-dependent calcium channel in epileptics gradually draws researchers' attention, and then calcium antag...
近年来，随着对钙通道的研究的深入，尤其是电压依赖性钙通道在痫性活动中的作用越来越受到重视，钙拮抗剂也迅速成为抗癫痫药物的一个重要组成部分。
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Results The age of the onset of symptoms ranged from 3 to 12 years. The clinical attacks lasted a variable time from 1 hour to more than 3 weeks. Definite medical causes were identified in 78% of the patients. Each patient had a prolonged change of consciousness, accompanied by psychological and behavioral changes. The characteristics of ictal EEG in CPSE patients generally included slow activity and δ or θ activity in the temporal region. After antiepileptic drug treatment, the conditions of 11 patients were under complete control, 4 patients had no CPSE but complex partial seizures, and 2 patients had no improvement.
结果 17例CPSE患儿起病年龄为3～12岁，临床发作持续时间为1 h～3.5周；78%的患儿有明确的病因，CPSE临床表现多样，所有病例均有意识障碍，同时伴有不同程度的精神和行为异常，发作期脑电图主要以基本电活动变慢伴颞部局灶性慢波或痫样放电的持续或周期性发放为特征，经抗癫痫药物等治疗，11例患儿持续发作完全控制，4例持续状态控制，仅有部分性发作，2例未能控制。
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Thioridazine：甲硫达嗪
⑥抗精神药物:如氯丙嗪、甲硫达嗪(Thioridazine)适用于有破坏性行为的患儿. ⑦抗癫痫药:如苯妥英钠、扑痫酮适用于伴发惊厥的患者. 忌用巴比妥类的镇静剂,因有时反可使症状加重 疗程依病情轻重而定轻者服药6月~1年,重者要