抗激酶

基本解释 (translations)

antikinase

与抗激酶相关的网络例句 [注：此内容来源于网络，仅供参考]

Abstract］ Objective To discuss the cooperation of dextran-40 and urokinase on anti-platelet agglutination.

目的 探讨低分子右旋糖酐与尿激酶在抗血小板聚集上的协同作用。

In addition, in without fight coagulate below no-no card premise, cure is as follows:(1) fights coagulate cure: Buzzing?0 Mg joins 5~7 D of the Jing Di in physiological saline 500 ML, detect at the same time cruor zymogen time, general 18~21 S, do not exceed 30 S, the 3 D before heparin of out of service is added with Huafalin [200 thousand unit adds kinase of 1];(2) make water 5% grapes...

此外，在无抗凝禁忌证前提下，治疗如下：(1)抗凝治疗：肝素60 mg加入生理盐水500 mL中静滴5~7 d，同时检测凝血酶原时间，一般18~21 s，不超过30 s，停用肝素前3 d加用华法林[1]；(2)尿激酶20万单位加5%葡萄。。。

Methods Of 219 early pregnancy women taking RU486,30 cases as effective group,23 cases as ineffective group and 16 cases as curette abortion group,and they were labeled immunohistochemically with PR,ER and EGFR,PKC,raf-1,MEK-1 and Bcl-2,respectively.

219例服用RU486早孕药物流产者，对其有效组30例，失败组23例，人流组对照16例，以免疫组化法分别标记孕激素受体、雌激素受体、表皮生长因子受体、酪氨酸蛋白激酶C、分裂激活蛋白激酶(MEK-1)、细胞转化分裂介质(raf-1)和抗凋亡蛋白(Bcl-2)。

Methods Of 219 early pregnancy women taking RU486,30 cases as effectiv e group,23 cases as ineffective group and 16 cases as curette abortion group,and t hey were labeled immunohistochemically with PR,ER and EGFR,PKC,raf-1,MEK-1 and Bcl-2,resp ectively.

219例服用RU486早孕药物流产者，对其有效组30例，失败组23例，人流组对照16 例，以免疫组化法分别标记孕激素受体、雌激素受体、表皮生长因子受体、酪氨酸蛋白激酶C、分裂激活蛋白激酶(MEK-1)、细胞转化分裂介质(raf-1)和抗凋亡蛋白(Bcl-2)。

We coupled the IgG of monoclonal antibody N34 specific to UK and the Fab of monoclonal antibody SZ-51 specific to the membrane protein GMP-140 of activated platelet. The bispecific antibody (N34 SZ-51) is able to bind UK and plasma-clot simutaneously. It enhanced plasma clot lysis 5 fold by HUK whereas it enhanced plasma clot lysis 38 times by LUK. UK in association with the bispecific antibody didn't decrease the concentration of fibrinogen in the assay supernatants.

利用抗体介导使纤溶酶原激活剂定向到血栓表面，可大大提高其纤溶作用，我们用双功能团试剂将抗尿激酶的单克隆抗体N34的IgG和抗活化血小板膜蛋白GMP-l40的单抗SZ-5l的Fab片段通过二硫键共价偶联，合成的双专一性抗体（N34-SZ-51）既具有血栓亲和性也具有尿激酶亲和性，从而增加了尿激酶对血栓的专一性，使高分子量尿激酶溶栓率提高了5倍，使低分子量尿激酶溶栓率提高了38倍之多，且不影响血浆中纤维蛋白原的含量。

Results These two patients were confirmed to suffer from DMD. They were characterized by typical features of DMD including typical clinical manifestations, increased serum enzymes, EMG presenting myogenic impairment, HE staining presentation belonging to DMD, negative dystrophin in brother, and inconstantly positive on the sarcolemma of sister. Furthermore, no deletion or duplication was found in the 1-79 exons of dystrophin gene. The suffering brother and sister carried the same maternal X chromosome.

结果 兄妹二人符合DMD诊断，具有典型的DMD临床表现，肌酸激酶、肌酸激酶同工酶、乳酸脱氢酶、羟丁酸脱氢酶和谷草转氨酶的水平均显著高于正常值，肌电图呈肌源性损害，肌肉HE染色符合DMD，男患者的抗肌萎缩蛋白表达阴性，女患者的少量肌纤维仍可见不连续膜阳性，两患者抗肌萎缩蛋白基因的1~79号外显子未见缺失和重复突变，女患者与男患者携带相同的母源性X染色体。

Studies also indicated that genistein exsists not only in soybeans but also in many kinds of plants such as vegetables and fruits.As a potential anticancer agent, the actional mechanisms of genistein mainly includes as follows:First, genistein can depress the activity of protein tyrosine kinase and transduction pathways for the phosphorylation of receptors and mitosis signal. So genistein can lead to cells' proliferation depressed. Second, genistein has minimal effects of phytoestrogens. It can be combined with estrogen receptor and improve the synthesis of cellular sex hormone binding glulobin, and improve the activity of UDP-glucuronyl transferase. Through these pathways, it can inhibit the cell activity of breast cancer and prostate cancer.

作为一个很有潜力的抗肿瘤物质，三羟异黄酮的作用机制主要包括：①抑制蛋白酪氨酸激酶活性，可阻抑PTK引起的受体磷酸化和有丝分裂的信号传递，导致癌细胞增殖受抑；②弱雌激素作用：可通过与体内雌激素受体结合，并可增加细胞内性激素结合球蛋白的合成，增加UDP-葡糖醛酸转移酶的活性等途径抑制乳腺癌和前列腺癌细胞活性；③拓扑酶Ⅰ和Ⅱ抑制剂，抑制细胞活性；④上调细胞周期性负性调节因子P21WAF1/CIP1的表达，使之负性调节因子作用增强；⑤可阻止胰岛素样生长因子-Ⅰ、肝细胞生长因子和神经生长因子的作用而抑制肿瘤生长；⑥其他：抗氧化作用、抑制热休克蛋白、诱导细胞凋亡、抑制新生血管生成和抑制多种耐药相关蛋白等。

IκB kinase-β is associated with the development of inflammation and cancer, and it is a new target for coring inflammation and cancer.

IκB激酶－β与炎症和肿瘤的发生、发展密切相关。目前，IKK-β抑制剂的研究与开发已成为抗炎、抗肿瘤药物研究的一个新方向。

Glioma is still one of refractory disease in the neurosurgical field; the development of new primary and adjuvant treatment is vital. Recently, the gene therapy of glioma is developed rapidly and there are many methods about the gene therapy that include: suicide gene therapy, immunologic gene therapy, drug resistangce gene therapy, angiostatin gene therapy and so on. The sucide gene therapy is the most potential approach of antitumer, these nonmammalian genes encode enzyme that convert nontoxic prodrugs into highly toxic metablites. Cells transfected with suicide genes are targeted for specific negative selection, witch can be induced by administrtion of the corresponding produg. Among the enzyme/produg combinations, two of the best characterized system are herpes simplex virus thymidine kinase /ganciclovir and Escherichia coli cytosine deaminase /5-flourocytosine (5-FC). The formor can convert the antiviral nucleoside analogs acyclovir , ganciclovir to their nucleoside monophosphate derivatives, the monophosphate forms are subsequently phosphorylated by endogenus cellular kinases to triphosphates, these molecules are potent inhibitors of DNA synthesis.

近年来脑胶质瘤的基因治疗发展迅速，应运而生的方法有自杀基因、免疫基因、多药耐药基因以及抗血管生成基因等，其中自杀基因被认为是最有前景的基因治疗方法，它又称病毒介导的酶／药物前体疗法，是利用转基因技术将哺乳动物细胞中所不含有的自杀基因转入到哺乳动物肿瘤细胞中，该基因表达的产物可将无毒的药物前体转化为毒性药物，从而选择性杀伤该肿瘤细胞，常用的自杀基因有单纯疱疹病毒-胸苷激酶基因和大肠杆菌胞嘧啶脱氨酶基因，前者催化无毒性抗病毒核苷类似物如丙氧鸟苷、无环鸟苷等成为单磷酸核苷衍生物，然后在内源性细胞激酶作用下转化为具有明显毒性的三磷酸核苷，作为DNA合成链的终止剂和DNA合成酶的抑制剂，干扰细胞DNA的合成；后者编码的胞嘧啶脱氨酶可催化5-氟胞嘧啶（5-FC）脱氨成为5-氟尿嘧啶（5-FU），然后代谢为有毒性的5-氟尿嘧啶-5′三磷酸（5-FUTP）和5-氟-2′脱氧尿嘧啶-5′磷酸（5-FdUTP），5-FUTP通过与UTP竞争性结合而抑制mRNA和tRNA的合成，5-FdUTP则作用于胸苷合成酶，导致TMP衰竭而阻止DNA的合成，最终诱导肿瘤细胞凋亡。

Objective: There are three pathways for indirubin, an anti-tumor component of Chinese traditional medicine, to inhibit the growth of cancer cells. The three pathways are competitively inhibit CDKs with the kinase's ATP-binding pocket, directly inhibits c-Src kinase and block constitutive Stat3 signaling, and inhibition of nucleoside transporters respectively.

目的：中药抗肿瘤成份靛玉红可通过3种途径对肿瘤细胞的生长发挥抑制作用，分别为竞争性拮抗CDK激酶的ATP结合位点；抑制Src激酶、阻断Stat3信号通路；抑制核苷酸转运蛋白。

与抗激酶相关的网络解释 [注：此内容来源于网络，仅供参考]

adenine：腺嘌呤[维生素类药]

Ademetionine 腺苷蛋氨酸[抗脂肪肝药] | Adenine 腺嘌呤[维生素类药] | Adenosine Cyclophosphate 环磷腺苷[蛋白激酶致活药]

aneurin：抗神经炎素

维生素B1,也称硫胺素(Thiamin)因其发现与预防和治疗脚气病(Beriberi)有关,又称作抗神经炎素(Aneurin)在肝、肾和红细胞中,在硫胺素焦磷酸激酶的作用下,硫胺素与三磷酸腺苷(ATP)结合形成焦磷酸硫胺素(TPP),经过一系列转化为硫胺素单磷酸盐!

antitoxin：抗毒剂

antithrombokinase; antithrombopiastin 抗凝血激酶 | antitoxin 抗毒剂 | antitrypsin 抗胰蛋白酶

tetanus antitoxin：破伤风抗霉素

tolbutamide 甲磺丁脲,甲糖宁 | tetanus antitoxin 破伤风抗霉素 | urokinase 尿激酶

Developmental Biology：发育生物学

该研究成果已在美国发育生物学会会刊爱思唯尔期刊>(Developmental Biology)在线发表. 第二项进展主要是由朱蓉博士和张义兵博士等共同完成. 该研究主要是围绕鱼类中是否存在dsRNA依赖的蛋白激酶PKR以及鱼类PKR是否具有抗病毒功能而展开的.

myoglobin：肌红蛋白

镁(Magnesium)摩尔渗透压浓度(Osmolality) 二氧化碳(C02) 过氧化物酶一抗过氧化物酶(PAP)C一肽(C-Peptide)脑钠肽(BNP) 高敏C-反应蛋白(hs-CRP) 总肌酸激酶(Total CK)肌酸激酶同工酶CK(CK-MB) 肌红蛋白(Myoglobin)肌钙蛋白I(Tro

thromboplastin, thrombokinase：促凝血酶原激酶, 凝血激酶

thrombocyte, blood platelet 血小板 | thromboplastin, thrombokinase 促凝血酶原激酶, 凝血激酶 | thromboplastinogen, anti-hemophilic globulin 凝血激酶原, 抗血友病球蛋白

antiketogenic substance：抗产酮物质

"antiketogenic hormone","抗产酮激素" | "antiketogenic substance","抗产酮物质" | "antikinase","抗激酶"

antikinase：抗激酶

"antiketogenic substance","抗产酮物质" | "antikinase","抗激酶" | "antiknock","抗震"

Rana nigromaculata：青 蛙

236 蛋白激酶R催化结构域(PKR-KD)的基因克隆、蛋白纯化和结晶251 脆弱类杆菌核酸扩增(PCR)荧光检测试剂盒的研制377 青蛙(Rana nigromaculata)皮肤抗菌活性物质的分离纯化、结构鉴定及抗384 萝卜蚜(Lipaphis erysimi)对天敌捕食的行为反应和繁殖