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Background : Chronic renal failure occurs as a clinical syndrome. 57.9% of CRF cases are associated with erection dysfunction. For patients at the terminal phase of nephropathy, ED incurrence rate accounts for 85.4%, including 25.4% of complete ED, 35.4% of medium ED and 24.6% of slight ED.
研究背景随着慢性肾功能衰竭治疗水平的提高和慢性肾功能衰竭病人寿命的增加,人们逐渐认识到慢性肾功能衰竭性阴茎勃起功能障碍已严重影响病人的生活质量,CRF病人中约57.9%患有ED。
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The times of penis intromission into vagina of estrous female rats during 30 minutes observation and intracavernosal pressure during erection resulting from stimulation of the autonomic innervation of the penis were measured after 2 weeks and 2 months of the operation.
应用内皮细胞特异性标志物CD-31分子和平滑肌特异性标志物α-actin对处理后2周的大鼠阴茎海绵体组织行免疫组织化学染色,了解雄激素对大鼠阴茎组织血管内皮细胞和平滑肌细胞的影响。
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Scleroma albuginea and the penis can also affect the membrane compartment, such as erectile tissue when in the normal extension, the extension and relaxation, and induration Department impede erection and retraction of the penis, causing erection of the penis bending to the side, a direct impact on the penis inserted into the vagina.
硬结还可影响白膜与阴茎筋膜等膜性组织在阴茎勃起时的正常伸展、延长与舒张,并在硬结处阻碍与牵拉勃起的阴茎,造成勃起的阴茎向患侧弯曲,直接影响阴茎插入阴道。
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Balanitis affects the foreskin and balanoposthitis affects the head of the penis.
balanitis影响包皮和龟头影响头部的阴茎。
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Under the same concentration, tadalafil induce higher ratio of relation responses in the smooth muscles of CRF rabbit cavernosal strips, compared with papaverine and sodium nitroprussiate, with most significant difference occurring under the concentration indicators of 10-5 mol/L and 10-4 mol/L (P.01). Conclusions The effects of tadalafil on relaxation responses in CRF rabbit cavernosal strips highly depend on its concentration. The effect of tadalafil on relaxation responses in CRF rabbit cavernosal strips is better than that of papaverine and sodium nitroprussiate. Tadalafil may be an effective drug for treating CRF reduced erection dysfunction.
同一浓度下,他达拉非对慢性肾功能衰竭兔阴茎海绵体平滑肌舒张百分比与罂粟碱、硝普钠相比较,舒张百分比均大于罂粟碱和硝普钠,且在10~(-5)mol/L、10~(-4)mol/L浓度,他达拉非对慢性肾功能衰竭兔阴茎海绵体平滑肌舒张百分比,与罂粟碱、硝普钠相比较有显著性差异(P<0.01)结论他达拉非对慢性肾功能衰竭兔阴茎海绵体平滑肌舒张反应的影响具有浓度依赖性,他达拉非对慢性肾功能衰竭兔阴茎海绵体平滑肌舒张反应的影响优于罂粟碱及硝普钠,他达拉非可能是治疗慢性肾功能衰竭性阴茎勃起功能障碍的理想药物。
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In the study, we established the animal model of diabetic ED successfully. Modern medical methods such as routine lightscopy, pathology, transmission electroscopy, scanning electroscopy, fluorospectrophotometer and radio-immunity were employed. From the aspects of pathomorphism, cellular supermicrostucture and neurocrine, we observed the mixture's effect on status of the whole animal model and penial erection, the fast plasma glucose, protein non-enzyme gycosylation, nitric oxide synthase , testosterone. In contrast with control groups, the mixture could apparently slow down the corpus cavernosum penial, vascular, neural pathologic progression of the diabetic rats and had a better result than diabetic pill, invigorating yang and restoring normal capsule and amino guanidine.
通过实验研究,成功建立了糖尿病性阴茎勃起功能障碍动物模型,利用常规光镜病理、透射电镜、扫描电镜、荧光分光光度计、放射免疫法等现代医学研究方法,从病理形态学、细胞超微结构、神经内分泌学等方面,观察了降糖起萎合剂对模型动物整体状态和阴茎勃起情况、空腹血糖水平、蛋白非酶糖基化、一氧化氮合酶、睾酮等实验指标的影响,与对照组比较提示降糖起萎合剂能明显延缓大鼠基于DM基础上的阴茎海绵体及血管、神经病变的病理进程,其疗效优于消渴丸、壮阳复春灵胶囊及氨基胍。
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The distance between the skin which the needle stab into and the ligamentum, is (72.2±0.2)mm and between the skin which the needle stab into and the pudenda nerve is (80.2±0.1 ) mm. Conclusion: We should have a specific depth and angle when acupounct into the acupoint of Zhenyang, to make it sure to get the specific feeling of acupunting. The main reason of getting the specific feeling of acupunting is the needle may touch the pudendal nerve.
针刺&振阳穴&产生特殊针感可能是由于直接刺激到了阴部神经,或由于针刺时引起局部肌肉组织收缩牵拉刺激阴部神经所产生的,治疗阳痿的作用机制可能是通过调节大脑皮质和脊髓节段反射来影响阴茎勃起功能的。
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The experimental study of dog sacral nerve distribution and its influence on lower urinary tract function:For further understanding of the distribution of dog sacral nerve in bladder, urinea and penis, and in order to set up theoretical basis for selective sacral nerve rhizotomy in treating spastic bladder after spinal cord injury, 12 dogs were respectively given electrical stimulation to S 1 3 nerve roots and the contraction of musculus sphincter urethrae and detrusor urinae, the change of bladder pressure and penis erection were examined and recorded.
犬肪神经对下尿路的支曰及功能影响的实验研究:为进一步明确犬骰神经对膀耽、尿道及阴茎的支配情况,并为选择性骰神经根切断治疗脊髓损伤后痉挛性膀眈寻找理论依据,我们电刺激12条家犬的S;-/经根,通过尿流动力学检查及电生理检测来观察其逼尿肌、括约肌的收缩及阴茎勃起情况。
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Rian: Well how do you think listening to the sound of two dikes go down on each other for the past nine months has affected him.
:那你认为在过去的九个月里听到两个男人互吞阴茎的声音会对他有什么影响?
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Objective:To evaluate the effect of circumcision on the glans penis sensitivity by comparing the changes of the glans penis vibrotactile threshold between normal men and patients with simple redundant prepuce and among the patients before and after the operation.
目的:比较单纯包皮过长患者与正常人,以及单纯包皮过长患者在包皮环切术前、术后阴茎头振动感觉阈变化,评估手术对阴茎头敏感度的影响。
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chancroid:软性下疳
整体来说,研究发现不令人感到意外,但他们确实指出需要长期研究;此研究是有趣的,但重点是披衣菌和淋病是包含在尿道而不是阴茎上皮,所以他们不是受男性割包皮影响的疾病元凶,除非是软性下疳(Chancroid)、疱疹(Herpes)、梅毒(Syphilis),
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premature ejaculation:早泄
(五)早泄(premature ejaculation) 性交时男性对于射精缺乏合理的控制能力,以致在双方不愿结束性交之前就射精,使双方均不能获得快感. 严重者可在阴茎插入阴道前或尚未勃起时就射精. 早泄绝大多数为心因性的,龟头或包皮的炎症、尿道炎、前列腺炎亦可反射性地影响脊髓中枢,
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perineum:会阴
(4)如果睾丸未降入阴囊内而隐居在腹腔、腹股沟管内或阴茎根部、会阴(perineum)部等处,称为隐睾症(cryptorchism). 触诊时应仔细寻找,可在其他部位触及睾丸,但多较正常柔软而细小. 隐睾以一侧为多,偶有双侧者. 若为双侧可影响生殖器官及第二性征的发育.
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epispadias:尿道上裂
尿道上裂(epispadias)系先天性尿道发育反常,尿道口位于阴茎之背侧,其远端尿道之背侧壁缺如,呈沟状. 其发生是在胚胎发育过程中,尿直肠膈向前发育. 使尿生殖窦不是正常的位于生殖结节之后方,而在生殖结节之前相连接. 影响了生殖结节在前上中线的融合.