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Objective:To investigate the effects of hyperosmotic dextroglucose,mannitol and sorbitol solutions on the amplitude and conduction velocity of compound action potential of the sciatic nerve of frog.
目的：观察葡萄糖、甘露醇、山梨醇3种高渗溶液对蛙坐骨神经干复合动作电位的幅度及传导速度的影响。
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Results: compared with the control group, the amplitude and conduction velocity of biphasic action potential were gradually and significantly reduced in the hyperosmotic dextroglucose sub groups (concentrations at 20% and 40%), hyperosmotic mannitol sub group (concentration at 20%) and hyperosmotic sorbitol sub groups (concentrations at 20% and 40%) in a time dependent manner.
结果：与对照组比较，20%、40%葡萄糖组，20%甘露醇组和20%、40%山梨醇组的动作电位幅度有显著降低，传导速度有显著减慢，呈时间依赖关系；10%葡萄糖组、10%甘露醇组和10%山梨醇组高渗溶液均可使蛙坐骨神经干动作电位幅值有不同程度上升，传导速度略微减慢。
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Systematic isopiestic measurements have been carried out at the temperature 298.15K for the mixed nonelectrolyte aqueous solution saturated with an electrolyte {water (A1)+cadmium chloride〓(A2)+sorbitol +sucrose} and the mixed electrolyte aqueous solution saturated with another electrolyte {water (A1)+barium chloride〓(A2)+sodium chloride +ammonium chloride}, taking sodium chloride or calcium chloride as the reference standard.
以NaCl或CaCl〓为参考物，系统地测定了298.15K时一种电解质饱和的混合非电解质溶液{H〓O(A1)+CdCl〓(A2)+山梨醇+蔗糖}和一种电解质饱和的混合电解质溶液{H〓O(A1)+BaCl〓(A2)+NaCl+NH〓Cl}的等压平衡。
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Systematic isopiestic determinations have been made at the temperature 298.15 K for the mixed nonelectrolyte aqueous solution saturated with an electrolyte and a nonelectrolyte {water (A1)+sodium chloride〓(A2)+glycine〓(A3)+sorbitol+ sucrose}, the mixed nonelectrolyte solution saturated with two electrolytes {water (A1)+sodium chloride〓(A2)+barium chloride〓(A3)+sorbitol +sucrose}, and the mixed electrolyte solution saturated with another electrolyte and a nonelectrolyte {water (A1)+barium chloride〓(A2)+mannitol〓(A3)+ sodium chloride +ammonium chloride}, taking sodium chloride or calcium as the reference standard.
以NaCl或CaCl〓为参考物，系统地测定了298.15K时一种电解质和一种非电解质饱和的混合非电解质溶液{H〓O(A1)+NaCl〓(A2)+甘氨酸〓(A3)+山梨醇+蔗糖}、两种电解质饱和的混合非电解质溶液{H〓O(A1)+NaCl〓(A2)+BaCl〓(A3)+山梨醇+蔗糖}以及一种电解质和一种非电解质饱和的混合电解质溶液{H〓O(A1)+BaCl〓(A2)+甘露醇〓(A3)+NaCl+NH〓Cl}的等压平衡。
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Sorbitol Solution：山梨醇溶液
硫磺酸 sulfuric acid | 山梨醇溶液 Sorbitol Solution 70 | 二氯甲烷 METHYLENE CHLORIDE 99%
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osmotic diuretics：渗透性利尿药
脱水药又称渗透性利尿药(osmotic diuretics)是指能使组织脱水的药物. 包括甘露醇、山梨醇、高渗葡萄糖等. 它们的药物作用完全决定于溶液中药物分子本身所发挥的渗透压作用. 它们应具备如下特点:①易经肾小球滤过;②不易被肾小管再吸收;