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The mice inoculated with Coxiella burnetii intrana- sally developed interstitial pneumonia,while the primary pathological changes of mice inoculated intraperitoneally are granulomas in spleen and liver.2.The pathological changes became more severe followed the dosage increasing.3.Coxiella burnetii can be detected in spleen and liver at day 2 after inoculation.the lesion became more and more serious from day 2 to day 12.The characteristic changes were observed at day 7,and recovered at day 14. 4.The reticuloendothelial system are main target of Coxiella burnetii.The pathogen was detected in cytoplasm of monocyte -macrophages of spleen, liver, lung, and endothelioid cells of blood vessel. 5. Coxiella burnetii can be found in macrophages lysosomes by electron microscopy. Most of them are round or rod, and polymorphic shape can also be observed in different size.
结果:1、通过不同感染途径的实验证实,滴鼻感染的小鼠主要表现为间质性肺炎,而腹腔注射感染小鼠则以脾脏、肝脏肉芽肿为主要病变。2、通过不同剂量的感染实验发现,随着感染Q热立克次体剂量的加大,动物病变愈加严重。3、通过感染后不同时间的动态病理学观察发现,在腹腔注射后第2d的脾和肝脏即可发现病原体,主要脏器的病理变化从第2d到第12d逐渐加重,第7d动物的病变最典型,至感染后14d动物的受损器官已开始出现修复性变化。4、 Q热立克次体主要侵害机体的网状内皮系统,在感染小鼠的肝、脾、肺和外周血管单核巨噬细胞以及血管内皮细胞胞浆中查见病原体。5、透射电镜观察可见Q热立克次体主要位于巨噬细胞吞噬溶酶体内,呈多形性,多见圆形和杆状,大小不一。
- 更多网络解释与多形噬细胞相关的网络解释 [注:此内容来源于网络,仅供参考]
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microphage:巨噬细胞
大吞噬细胞指巨噬细胞(microphage),小吞噬细胞指中性粒细胞(neutrophilic granulocyte),又称多形核白细胞(polymorphonuclearleucocyte,PMN). 12.炎症(infiammatory) 机体受到有害刺激时所表现的全身性防御应答,其作用为清除有害异物,
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leukocidin:杀白细胞素
3.杀白细胞素(Leukocidin)含F和S两种蛋白质,能杀死人和兔的多形核粒细胞和巨噬细胞. 此毒素有抗原性,不耐热,产生的抗体能阻止葡萄球菌感染的复发. 4.肠毒素(Enterotoxin)从临床分离的金黄色葡萄球菌,约1/3产生肠毒素,按抗原性和等电点等不同,
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polyblast:多形噬细胞
polybinarysystem 多二进制 | polyblast 多形噬细胞 | polyblepharia 额外睑