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The lesion, the changes of activity of cholinesterase and acid phosphatase of motor neurons in lateral nucleus of spinal cord anterior horn, the function of axoplasm transportation and nerve conduction, the regeneration of axons and myelin sheath, and the recovery of sciatic nerve function were examined at 7, 14, 30 and 90 days intervals after operation, using Nissl and enzyme histochemistry staining, electrophysiological technique, hydrogen-peroxide oxidoreductase retrograde trace method, axon image analysis, and measurement of sciatic function index. The spinal cord anterior horn of injury side was compared to the correspondence region of spinal cord.
分别于术后7、14、30和90d应用酶组织化学方法、电生理方法、HRP (hydrogen-peroxide oxidoreductase)逆行示踪方法、轴突图象分析方法以及坐骨神经功能指数(sciatic nerve function index,SFI)测量等方法检测坐骨神经损伤后对应脊髓神经元的存活率、神经元胞体酶系变化、损伤神经在轴浆运输、电传导以及轴突、髓鞘再生等方面的恢复情况,探索外周神经损伤后OECs及几丁质对神经元的保护作用以及对新生神经功能恢复的作用,为外周神经损伤的治疗提供新的理论基础。
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Although there were no appearing obviously extracorticospinal tract damage ormental disorder and so on in these non- cerabral type HLD patients, the results of neurologic check,chemical examination,B ultrasonic wave and Electrophysiology show that it also exist deposition of copper in all body' s tissue and organic.
非脑型HLD患者虽然临床上均尚未出现明显锥体外系损害表现、精神障碍等,但神经系统检查、化验、B超及神经电生理等检查结果表明依然存在着全身组织器官的铜沉积表现,头颅CT和MRI检查却基本上尚未产生脑组织明显异常的结构性改变。
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Methods The clinical data of 1196 PD cases ,who were diagnosed at the Extrapyramidal Disease Center in TianJin General Hospital, were analyzed retrospectively.
采用临床病例分析统计方法,回顾性分析了1196例在天津医科大学总医院神经内科锥体外系门诊确诊的PD患者的临床资料。
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So people attach great importance to the damage by its toxicity. The main target organ of manganese is nervous system. At the early stage, its major symptoms are neurasthenic syndrome and autonomic nerve functional disorder, and then the apparent damage to extracorticospinal tract nerves, similar to that of a Parkinson's disease.
锰的主要毒作用器官是神经系统,早期以神经衰弱综合征和植物神经功能紊乱为主,继而可出现明显的锥体外系神经受损症状,与帕金森病(Parkinson's disease,PD)症状类似,流行病学研究认为锰是PD发病的环境危险因素之一。
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Acetylcholinesterase in the nervous system of insects is one of the most important enzymes, in the central and peripheral nervous system and the acetylcholine receptor involved nerve-nerve and nerve-muscle synaptic transmission between the action potential, and its main function is catalyzed hydrolysis cationic neurotransmitter acetylcholine. At present, in the natural products active material, the AChE ester moves the spot inhibitor physostigmine was studied clearly.
乙酰胆碱酯酶(Acetylcholinesterase,AChE)是昆虫神经系统中最重要的酶系之一,在中枢及外周神经系统中与乙酰胆碱受体一起参与完成神经-神经及神经-肌肉突触之间动作电位的传递,其主要生理功能是催化水解阳离子性神经递质乙酰胆碱。
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2B8a was weakly reactive to neutrophils (23.72%) and negative for T cells, NK, DC, RBC and Plt. The antibody reacted to all 3 marrow CD34+ cells with an average positive rate of 39.33% while it was negative for G-CSF-mobilized CD34+ peripheral blood stem/progenitor cells (PBSC, 1.25%). Cell line analysis showed that the antibody notably reacted to three out of 4 cell lines (Raji, SMS-SB, Nalm-6 and Nall-1) with the positive rates of 98.78%, 98.61%, 94.93% respectively and weakly to one of them with 5.68% in B lineage cell lines and monoblastic cell line (U937, 67.78%) while it was only weakly positive or negative for other myeloid leukemia cell lines including Meg01 (33.40%), HL-60 (29.70%),K562 (28.19%), KG1a (16.23 %) and HEL92.1.7 (8.02%). Among 4 T lineage leukemia,5 neuroblastoma and 1 colon cancer cell lines tested, only Molt-3 was found weakly positive (31.40%) for 2B8a, while the remaining 3 T cell lines (Molt4, JM and CCRF-CEM), 5 neuroblastoma cell lines (LA-N1, KCNR, BE, SK-N-SH, SK-N-AS) and the colon cancer cell line (HR8348) tested were negative.
结果表明: 2B8a抗原在外周血B细胞上表达(3/3例,平均阳性细胞数为26.29 %),而在T淋巴细胞和NK细胞上不表达(0/3例);在粒细胞和单核细胞上阳性表达均为2/3例,平均阳性细胞数分别是23.72 %和59.84 %;在DC细胞、红细胞和血小板上均不表达(0/3例)。2B8a抗原在骨髓CD34+细胞上的阳性表达是3/3例,平均阳性细胞数39.33 %,而在G-CSF动员的外周血CD34+细胞上的阳性表达仅1/3例,平均阳性细胞数为1.25 %。2B8a抗原在B系细胞系Raji、SMS-SB、Nalm-6和Nall-1上的平均阳性细胞数分别为98.78 %、98.61 %、94.93 %和5.68 %;在T系细胞系Molt-3上的平均阳性细胞数为31.40 %,而在Molt-4、JM和CCRF-CEM 细胞上不表达;在髓系细胞系U937、Meg-01、HL-60、K562、KG1a和HEL92.1.7上的平均阳性细胞数分别为67.78 %、33.40 %、29.70 %、28.19 %、16.23 %和8.02 %;在神经母细胞瘤细胞系SK-N-SH、KCNR、BE、LAN-1和SK-N-AS细胞以及结肠癌细胞系HR8348细胞上均不表达,而在羊膜细胞系FL细胞上呈一定的阳性表达,平均阳性细胞数为45.03%。
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Cell line analysis showed that the antibody notably reacted to three out of 4 cell lines (Raji, SMS-SB, Nalm-6 and Nall-1) with the positive rates of 98.78%, 98.61%, 94.93% respectively and weakly to one of them with 5.68% in B lineage cell lines and monoblastic cell line (U937, 67.78%) while it was only weakly positive or negative for other myeloid leukemia cell lines including Meg01 (33.40%), HL-60 (29.70%),K562 (28.19%), KG1a (16.23 %) and HEL92.1.7 (8.02%). Among 4 T lineage leukemia,5 neuroblastoma and 1 colon cancer cell lines tested, only Molt-3 was found weakly positive (31.40%) for 2B8a, while the remaining 3 T cell lines (Molt4, JM and CCRF-CEM), 5 neuroblastoma cell lines (LA-N1, KCNR, BE, SK-N-SH, SK-N-AS) and the colon cancer cell line (HR8348) tested were negative.
结果表明: 2B8a抗原在外周血B细胞上表达(3/3例,平均阳性细胞数为26.29 %),而在T淋巴细胞和NK细胞上不表达(0/3例);在粒细胞和单核细胞上阳性表达均为2/3例,平均阳性细胞数分别是23.72 %和59.84 %;在DC细胞、红细胞和血小板上均不表达(0/3例)。2B8a抗原在骨髓CD34+细胞上的阳性表达是3/3例,平均阳性细胞数39.33 %,而在G-CSF动员的外周血CD34 细胞上的阳性表达仅1/3例,平均阳性细胞数为1.25 %。2B8a抗原在B系细胞系Raji、SMS-SB、Nalm-6和Nall-1上的平均阳性细胞数分别为98.78 %、98.61 %、94.93 %和5.68 %;在T系细胞系Molt-3上的平均阳性细胞数为31.40 %,而在Molt-4、JM和CCRF-CEM 细胞上不表达;在髓系细胞系U937、Meg-01、HL-60、K562、KG1a和HEL92.1.7上的平均阳性细胞数分别为67.78 %、33.40 %、29.70 %、28.19 %、16.23 %和8.02 %;在神经母细胞瘤细胞系SK-N-SH、KCNR、BE、LAN-1和SK-N-AS细胞以及结肠癌细胞系HR8348细胞上均不表达,而在羊膜细胞系FL细胞上呈一定的阳性表达,平均阳性细胞数为45.03%。
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The superior olivary nuclei receive signals from the cochlear nuclei and conduct them via the lateral lemnisci to the inferior colliculi .
上橄榄核接收从耳蜗神经核的讯号并引导他们经由丘系外核到下丘。
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Results They were characterized by onset before 18 monthes of age, frequent episodes of alternating paralysis lasting from a few minutes to several hours, together with transient occular palsies, nystagmus, choreoathetosis, autonomic dysfunction and development of congnitive impairment.
结果 6例患儿的临床特征为出生后18个月起内病,频繁发作,持续数分钟至数小时;短暂的眼球震颤,肌张力异常,舞蹈徐动样动作,植物神经机能紊乱和认知机能减退;睡眠可缓解无力及锥体外系症状。
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The protein expression of neuropeptide Y in pedigrees of type 2 diabetes is increased ascompared with normal controls.
2型糖尿病家系成员的外周血神经肽Y蛋白表达高于正常对照。
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antidepressant:抗抑郁药
以及一些新药如联苯丁哌啶类,哌迷清和氟斯必灵.它们大多数都有不良作用,其中以锥体外系综合征最痛苦.近年来出品的利培酮,奥氮平,吉布利酮等锥体外系副反应较轻而少.同:神经阻滞剂.抗抑郁药(antidepressant)一组用于治疗抑郁症状的精神活性药物,
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flaccid paralysis:弛缓性瘫痪
2、弛缓性瘫痪(flaccid paralysis) 又称为下运动神经元瘫、周围性瘫痪. 是由于下运动神经元(lower motor neuron),即脊髓前角细胞或脑干神经运动核及其发出的神经纤维病变所致. 它是接受锥体束、锥体外系和小脑系统各冲动的最后共同通路,