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Then Doripenem came into the market in the July ,2005. We studied the synthesis of Doripemen.Firstly, we synthesized the chemical 2 from the starting material------o-hydroxylphenylacylamine through Reformastky reaction, alkylation, Diekmann reaction, enolization, esterification and etc. Secondly, we synthesized the chemical 3 from L — hydroxylproline through the protection of carboxyl, amidogen and hydroxyl group, reduction by NaBr, SN_2 substitution and Mitsumobu reaction.
我们以水杨酰胺为起始原料,经Reformatsky反应、烷基化、Diekmann环合、烯醇化、酯化等反应合成双环母核2;再从L-羟基脯氨酸出发,经酯化保护羧基、保护氨基、保护羟基、硼氢化还原酯得醇、Sn2取代和Mitsumobu反应等合成巯基侧链3;最后由化合物3经脱保护、水解得硫醇,和化合物2在二异丙基乙基胺的作用下缩合,最后Pd/C催化脱保护,历经16步反应最终得到产物多尼培南。
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Moreover, this kind of novel complexes can be transformed to the analogous complexes as the complex 41 by treatment using 〓Ce〓.
而且这类络合物还可以在硝酸铈铵的作用下重新生成与络合物41结构类似的在萘环上带有取代基的双铁络合物。
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Sarcophagus beetles, which can not be replaced by Diptera, play a pivotal role not only in estimating PMI of dry human skeletal remains in the later stages decomposition of carcasses, but also the corruption, destruction, decomposition and posture changes of carcasses.
作为法医昆虫学的主要研究对象之一,嗜尸性甲虫在腐败晚期干化和白骨化尸体的死亡时间推断中具有双翅目昆虫所无法取代的重要意义,并对尸体的腐败、破坏、分解和姿势改变发挥着不容忽视的作用。
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Difunctional group reagents, which have metal and heteroatom linked to the olefinic carbon atoms, play an important role in organic synthesis, especially in developing many convenient methods for the stereoselective synthesis of substituted alkenes.
含金属或杂原子的双官能团试剂为取代烯烃的立体选择合成提供了许多方便方法,在有机合成中具有重要作用。
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The monoesters of furoin were synthesized by esterification of corresponding the acyl chloride with the furoin.
糠偶姻单酯在醋酸铵和醋酸作用下合成了新化合物2-取代-4,5-双恶唑。
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The central 5, 5'-disubstituted bipyridine units of each ligand coordinate theNi or Fe ion, while all the terminal 6-monosubstituted bipyridine units of the ligands keep free of coordination, as the result trinuclear triple-stranded helicate 〓 can not form. This is considered to be caused by the steric hindrance of the methylene substituents α to the chelating nitrogens of the terminal bipyridine units and the strain caused by linkage mode.
配体L〓与Ag作用得到〓,两个配体链相互缠绕着两个Ag离子周围形成双股螺旋结构并以头尾式排列(见图3),由于配体中位于配位N原子α或β位的末端甲基或次甲基取代基的空间位阻阻碍了头对头式异构体的形成,也正是由于配体头尾式排列而使Ag双股螺旋得以形成,这一结果表明该螺旋体的组装过程中自发地采取了空间阻碍尽可能小的那个构型。
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A new type of dimorphic denature starch cationic starch with lauril glucoside was synthesized by reaction of cationic starch with lauryl alcohol at the presence of emulsifier and catalyst.
在乳化剂和催化剂作用下,以阳离子淀粉和月桂醇为主要原料,合成了一种新型高取代度的双变性淀粉——阳离子淀粉月桂基糖苷。
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allylic rearrangement:烯丙位重排(作用)
allylic oxygenation | 烯丙位加氧 | allylic rearrangement | 烯丙位重排(作用) | allylic substitution | 烯丙位取代(取代在邻接于双键的C上)
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bimolecular reaction:二分子反应
bimolecular nucleophilic substitution 双分子亲核取代<作用> | bimolecular reaction 二分子反应 | bin system 仓储系统