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The method separates 30 Wistar bandicoot element of mildew of the Lai that it is rich randomly group and physiological saline group, respectively at tracheal inside after perfusion BLM and NS the 7th, 14, 28 days put to death.
方法将30只Wistar大鼠随机分为博莱霉素组和生理盐水组，分别于气管内灌注BLM及NS后第7、14、28天处死。
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Use one-time tracheal inside fiber of revulsive bandicoot lung changes A2 of element of mildew of infuse rich Lai model.
采用一次性气管内注入博莱霉素A2诱导大鼠肺纤维化模型。
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METHODS Bleomycin-induced mutagen sensitivity was used to measure chromatid breaks of 52 cancer patients and 76 controls.
应用以博莱霉素为诱变剂的敏感性检测方法，检测52例肿瘤患者和76例对照的染色体断裂情况，并对部分样本进行G显带。
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Objective: To determine the effects of curcumin on bleomycin-induced pulmonary fibrosis in rats.
中文摘要：目的：观察姜黄素对博莱霉素诱导的肺纤维化大鼠的肺功能的影响。
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Results:In the BRE group,the MAD was significantly lower and the SOD significantly highter than which of BLM group,and the degree of fibrosis was more mitigative than BLM group when examined by microscope,similar to that in the DXM group.
结果：灯盏花素注射液组与地塞米松注射液组结果相似，与博莱霉素组相比，肺组织SOD升高，MDA下降，光镜和电镜结果提示肺纤维化程度减轻。
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Abstract］ Objective To study the effect of zinc protoporphyrin,an inhibitor of heme oxygenase-1（HO-1）,on pathological and pathophysiologic changes of rat pulmonary fibrosis induced by bleomycin,and to investigate the role of Znpp in the pathogenesis of pulmonary fibrosis.
目的 观察血红素加氧酶-1（HO-1）抑制剂锌原卟啉对博莱霉素致大鼠肺纤维化模型病理和病理生理改变的影响，探讨Znpp在BLM诱导肺纤维化发病中的作用。
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Alternate Name: Blenoxane, Bleo, Blexane
别名：硫酸博来霉素，博莱霉素，Blexane
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30 male Wistar mice were divided into normal control group and groups treated by bleomycin on days 3,7,14,21,30.Each group included 5 mice, and the mice were treated by single intratracheal instillation with sterile saline solution or with 5 mg /kg body weight of bleomycin.
30只大鼠随机分为：(1)正常对照组 5只，经气管内一次性灌注生理盐水；(2)灌注博莱霉素分为博莱霉素3、7、14、21、30天组，每组各5只。
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5 And 5.0 mg/kg bleomycin were given intratracheally to every 15 mice in the bleomycin group, respectively. The mice in the control group were administrated the same volume of normal saline. Twenty-eight days after model establishment, all mice were sacrificed. Their left pulmonary lobe tissues were removed from mice and used for pathological section observation, and the right pulmonary lobe tissues were used for the hydroxyproline contents measurement. MAIN OUTCOME MEASURES: The survival condition of mice in 28 days.
60只小鼠随机数字表法分为博莱霉素组(n=45)和对照组(n=15)，博莱霉素组各选15只动物分别气管内注射不同剂量(2，3.5，5 mg/kg)的博莱霉素，对照组气管内注射相同体积的生理盐水，所有小鼠于造模后第28天处死并取其左肺叶制作病理切片，右肺叶作羟脯氨酸含量测定。
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But in day 14th and day 28th groups, the ratio of macrophagus positive area in lung interstitium was bigger than that of control group（ P 〈0.05 ）, with collagen fibers depositing in the lung interstitium gradually.
结论博莱霉素鼠肺毛细血管内皮细胞间紧密连接持续开放，与巨噬细胞在组织间浸润密切相关，并可能是博莱霉素致肺纤维化发生的重要因素。
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cobalt-57 vitamin B：钴57维生素
cobalt-57 bleomycin 钴-57博莱霉素 | cobalt-57 vitamin B 钴57维生素B | cobalt-58 vitamin B 钴58维生素B