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Between 6th and 14th weeks afteconstricted bilateral renal arteries, the blood pressure in the majority of RHRSP with cerebral infarction was obviously higher than in RHRSP without cerebral infarction (28. 8±2. 24kPa~32. 3 ±2. 88kPa, 26. 2±2. 01~28. 3±2. 33kPa respectively). Severe hyalinosis, fibrosis, wall hypertrophy, lumen stenosis, and even microaneurysm formation in cerebral small arteries in RHRSP with cerebral infarction were found, while slight to mild arteriolosclerosis in RHRSP was found without cerebral infarction.
本实验发现,RHRSP在经受不同水平的低血压后,产生脑梗塞的大多数(32/38只)在肾动脉狭窄术后第六周至第十四周,血压为28.8±2.24 kPa~32.3±2.88 kPa(216±17mmHg~242±22mmHg),显著高于无脑梗塞的RHRSP,并且发现这些RHRSP的脑内小血管呈严重的透明样变、纤维素样变性,管壁增厚,管腔狭窄,部分有微动脉瘤形成;而无脑梗塞的RHRSP的血压为26.2±2.01kPa~28.3±2.33 kPa(200±15mmHg~212±17.5mmHg),其脑内小血管呈轻至中度的动脉硬化改变。
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In situ terminal transferase-mediated dUTP nick end-labeling was used to detect the apoptosis of SMC in these two groups; We compared the elastic fibers, collagenic fibers, reticular fibers by special staining in the two groups by special staining.
结果 (1)常规HE染色组织学观察颅内囊性动脉瘤瘤壁均已丧失正常脑动脉壁的三层结构,表现的基本组织病理变化为损伤、变性、修复同时存在。
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rheumatic arteritis:风湿性动脉炎
风湿性动脉炎(rheumatic arteritis)可发生于冠状动脉、肾动脉、肠系膜动脉、脑动脉、主动脉和肺动脉等. 急性期,血管壁发生粘液样变性和纤维素样坏死,伴有炎症细胞浸润,可有Aschoff小体形成,并可继发血栓形成. 后期,血管壁因瘢痕形成而呈不规则增厚,
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fibrinoid degeneration:纤维蛋白样变性
⑸ 纤维蛋白样变性:纤维蛋白样变性(fibrinoid degeneration)是指纤维蛋白渗透入通常伴有变性改变的胶原组织或沉积于受损的血管壁及周围,使其呈现有折光的嗜伊红均质的外观,见于红斑狼疮、结节性多动脉炎等.
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amyloid angiopathy:淀粉样血管病
脑淀粉样血管病(amyloid angiopathy)是一种选择性发生在脑血管的病变,主要侵犯脑的软脑膜动脉和皮质动脉,并可波及脑实质的小动脉,受累血管的中层和外膜出现淀粉样物质沉积,导致脑内小动脉管壁淀粉样变性,使受累的动脉失去收缩功能,
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arteriasis:动脉壁变性
arterialthrombus 动脉血栓 | arteriasis 动脉壁变性 | arteriectasis 动脉扩张
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arteriectasis:动脉扩张
arteriasis 动脉壁变性 | arteriectasis 动脉扩张 | arteriectomy 动脉切除术