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PART FOUR EFFECTS OF MIL-4RA EXPRESSION VECTOR ON ASTHMATIC AIRWAY INFLAMMATION AND TH1/TH2 CELL DISFUNCTION THROUGH INTRAPERITONEAL ADMINISTRATION In the study of part three, we treated the mouse asthmatic model by intratracheal administration with mIL-4RA expression plasmid and observed obvious therapeutic effects. But intratracheal administration belongs to one of the insult therapies.
第四部分：腹腔注射mIL-4RA重组载体对哮喘小鼠气道炎症及Th失衡的干预作用前一部分研究中我们通过气道局部干预途径，即气管内直接滴注的方式，观察到mIL-4RA真核表达质粒对哮喘小鼠具有很好的治疗作用，但气管内滴注毕竟属有创性治疗，存在需要实验条件高，有较大的风险性，不易反复进行等缺点，这势必大大限制其在动物实验及进一步临床研究中的实际应用价值。
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Not easy to hear or understand; indistinctly articulated
含糊不清的：不易听到或理解；表达不清楚的
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Thus, we try to express the functional domains separately by fusing with maltose binding protein.
由於大量可溶的全长P蛋白不易获得，因此我们尝试将各个domain分开表达。
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Based on analysing the respective characteristics of regular PID controller in trational control theory and fuzzy logical controller in intelligent control theory, the idea and technique of expert system is introduced to develop a novel kind of hybrid intelligent controller. It can coordinate two kinds of control algorithms and tune the control parameters on-line for different working zones of the controlled process.(3) The hybrid knowledge expression model, which combines discrete state space model, fuzzy relational model and rule base model, is proposed based on analysing the characteristics of all kinds of knowledge expression models. The knowledge of the controlled process in different aspects can be expressed resonably by it. Based on the model mentioned above, the related optimization strategy for complex system is developed.
本文的主要贡献体现在：（1）以炼油厂的催化裂化装置和钢铁联合企业的大型焦炉装置两个典型的复杂工业过程为例，分析了工业大系统的许多不易控制的特性，并归纳了其中的几个典型特征；（2）针对经典控制理论中的常规PID调节器和智能控制技术中的模糊逻辑控制器各自的特点，通过引入专家系统的思想和方法，开发了一类混合式专家控制器，它同时具备在线协调两种不同控制规律和自动学习控制规则的能力；（3）通过分析各种知识表达模型的特点，提出了一类包括离散状态空间模型、模糊关系模型和规则基模型在内的混合知识表达模型，它能对过程知识在各个不同侧面给予合理的描述。
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This is a group of forgetful people without the responsibility for the arts and the balan...
我们无须把艺术变成精神的&苦行&，也不必用现成概念来平衡自己，即兴的虚构过程应能十分愉快，这是些超出定义的精神变化和某种直来直去却不易言说的表达方式。
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The application of virt ual reality in architecture is a very hot topi c. In a walkthrough system, a user can observe the architecture in different vie w interactively. This paper discusses the characteristics and requirements of a real time walkthrough system.
虚拟现实技术在建筑环境实时漫游中的应用一直是人们关注的热点，建筑师一般采用效果图来表达自己的设计思想，以前效果图都是手绘完成，花费时间长，不易修改。
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This study has achieved the following purposes,observed effects of different levels of noise exposure on the auditory function and the hearing organ of guinea pigs,explored optimal noise exposure profiles for research of NIHL susceptibility,established NIHL susceptibility model,148 differentially expressed genes of cochlea between NIHL susceptible and unsusceptible guinea pigs were screened by using suppression subtractive hybridization.The results of bioinformatics analysis showed that there are 34 sequences whose homology were larger than 80% and match sequence larger than 100 bp.
本研究观察了不同噪声暴露量对豚鼠听觉功能和听觉器官结构的影响，探讨了NIHL易感性研究的最佳噪声暴露方案，建立了NIHL易感豚鼠模型，利用抑制性消减杂交技术筛选NIHL易感与不易感豚鼠耳蜗的差异表达基因片段148条，生物信息学结果显示同源性大于80%且匹配碱基大于100 bp的片段共34条。
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The expression of activation antigen marker HLADR on CD4+ T cells is at a low level, which probably is correlated with nonsusceptibility to HIV1 in HEPS individuals by sexual transmission.
HEPS人群对HIV1的不易感性可能与其T淋巴细胞表面标志活化抗原表达水平处于较低水平状态有关。
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Objective To understand the distribution and immune activation status of T lymphocyte subsets in highly exposed HIV1 and persistently seronegative individuals, and explore the immunologic mechanism of nonsusceptibility to HIV1 by sexual transmission in HEPS individuals.
目的 了解经性传播途径高暴露HIV1持续血清阴性者淋巴细胞亚群表达及其免疫活化状态，探讨经性途径高暴露HIV1不易感的免疫基础。
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blueprint：蓝本
存在于个人或组织中的技术知识的另一项特征是,它们并不都是易于用语言明确表达出来的,因而就不易写进"蓝本"(blueprint)里,以独立于个人或组织的方式,象公式信息或专利信息一样进行传播.
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formalize：正式化
所谓的"隐性知识"(Tacit Knowledge),就是指未经正式化(Formalize)的知识,包括企业、经营者或员工的经验、技术、文化、习惯等,是属于个人经验与直觉的知识,较不易以言语来沟通及表达,表现为难以形式化、无法被具体化的技能.
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lysin：溶素
其中双链DNA噬菌体感染末期表达的内溶素(Lysin)和穴蛋白(Holin),特异性的破坏宿主菌细胞壁、细胞膜,从而释放出子代噬菌体,具有特异性强、有效、毒副作用小、细菌不易产生耐药性等优点,已经成为国内外研究的热点.