sleep around
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到处乱搞男女关系
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The effects and mechanism of GABAergic neurons, NOergic neurons, opioid peptide and cyclic adenosine monophosphate in the nucleus reticularis thalami on sleep-wakefulness cycle of rats and the effects and mechanism of the 5-HTergic nerve fibers project from the nucleus raphes dorsalis to RT on sleep-wakefulness cycle of rats were investigated with the methods of brain stereotaxic, nucleus spile, microinjection and polysomngraphy.1. The effects of GABAergic neurons in RT on sleep-wakefulness cycle of rats1.1 Microinjection of 3-mercaptopropionic acid (3-MP, a kind of glutamate decarboxylase inhibitor) into RT. On the day of microinjection, sleep only decreased a litter. On the second day, sleep marked decreased and wakefulness marked increased. On the third and fourth day, sleep and wakefulness stages resumed to normal.1.2 Microinjection of gamma-amino butyric acid (GABA 1.0μg) into RT enhanced sleep and reduced wakefulness compared with control; while microinjection of L-glutamate (L-Glu, 0.2μg) decreased sleep and increased wakefulness; microinjection of bicuculline (BIC, 1.0μg), a GABAA receptor antagonist, enhanced wakefulness and reduced sleep; microinjection of baclofen (BAC, 1.0μg), GABAB receptor agonist, had the same effects as GABA.2. The effects of NOergic neurons in RT on sleep-wakefulness cycle of rats2.1 Microinjection of L-arginine (L-Arg, 0.5μg) into RT decreased sleep compared with control, but there were on statistaical difference between L-Arg group and control; while microinjection of sodium nitroprusside (SNP, 0.2μg), a NO donor into RT, sleep marked decreased and wakefulness marked increased. Microinjection of nitric oxide synthase inhibitor, N-nitro-L-arginine (L-NNA, 2.0μg) into RT enhanced sleep and reduced wakefulness.2.2 After simultaneous microinjection of L-NNA (2.0μg) and SNP (0.2μg) into RT, SNP abolished the sleep-promoting effect of L-NNA compared with L-NNA group; after simultaneous microinjection of L-NNA (2.0μg) and L-Arg(0.5μg) into RT, we found that L-NNA could not blocked the wakefulness-promoting effect of L-Arg.3. The effects of opioid peptide in RT on sleep-wakefulness cycle of rats3.1 Microinjection of morphine sulfate (MOR, 1.0μg) into RT increased wakefulness and decreased sleep compared with control; while microinjection of naloxone hydrochloride (NAL, 1.0μg), the antagonist of opiate receptors, into RT, enhanced sleep and reduced wakefulness.3.2 After simultaneous microinjection of MOR (1.0μg) and NAL (1.0μg) into RT, the wakefulness-promoting effect of MOR and the sleep-promoting effect of NAL were not observed compared with control.4. The effects of cAMP in RT on sleep-wakefulness cycle of rats Microinjection of cAMP (1.0μg) into RT increased sleep and decreased wakefulness compared with control; microinjection of methylene blue (MB,1.0μg) into RT enhanced sleep and reduced wakefulness compared with control.5. The effects of the 5-HTergic nerve fibers project from DRN to RT on sleep-wakefulness cycle of rats5.1 When L-Glu (0.2μg) was microinjected into DRN and normal sodium (NS,1.0μg) was microinjected into bilateral RT. We found that sleep was decreased and wakefulness was increased compared with control; when L-Glu (0.2μg) was microinjected into DRN and methysergide (MS,1.0μg), a non-selective 5-HT antagonist, was microinjected into bilateral RT, We found that sleep was enhanced and wakefulness was reduced compared with L-Glu group.5.2 When p-chlorophenylalanine (PCPA, 10μg) was microinjected into DRN and NS (1.0μg) was microinjected into bilateral RT, We found that sleep was increased and wakefulness was decreased compared with control; microinjection of 5-hydroxytryptaphan (5-HTP, 1.0μg), which can convert to 5-HT by the enzyme tryptophane hydroxylase and enhance 5-HT into bilateral RT, could block the effect of microinjection of PCPA into DRN on sleep-wakefulness cycle.
本研究采用脑立体定位、核团插管、微量注射、多导睡眠描记等方法,研究丘脑网状核(nucleus reticularis thalami,RT)中γ-氨基丁酸(gamma-amino butyric acid ,GABA)能神经元、一氧化氮(nitrogen monoxidum,NO)能神经元、阿片肽类神经递质、环一磷酸腺苷(cyclic adenosine monophosphate,cAMP)及中缝背核(nucleus raphes dorsalis,DRN)至RT的5-羟色胺(5-hydroxytryptamine,5-HT)能神经纤维投射对大鼠睡眠-觉醒周期的影响及其作用机制。1 RT内GABA能神经元对大鼠睡眠-觉醒周期的影响1.1大鼠RT内微量注射GABA合成关键酶抑制剂3-巯基丙酸(3-MP,5μg),注射当天睡眠时间略有减少,第二日睡眠时间显著减少,觉醒时间明显增多,第三、四日睡眠和觉醒时间逐渐恢复至正常。1.2大鼠RT内微量注射GABA受体激动剂GABA( 1.0μg)后,与生理盐水组比较,睡眠时间增加,觉醒时间减少;而RT内微量注射L-谷氨酸(glutamic acid, L-Glu, 0.2μg)后,睡眠时间减少,觉醒时间增加;RT内微量注射GABAA受体阻断剂荷包牡丹碱(bicuculline,BIC,1.0μg)后,睡眠时间减少,觉醒时间增加;RT内微量注射GABAB受体激动剂氯苯氨丁酸(baclofen,BAC,1.0μg)后,产生了与GABA相似的促睡眠效果。2 RT内NO能神经元对大鼠睡眠-觉醒周期的影响2.1大鼠RT内微量注射NO的前体L-精氨酸(L-Arg,0.5μg)后,与生理盐水组对比,睡眠时间略有减少,但无显著性意义;而RT内微量注射NO的供体硝普钠(Sodium Nitroprusside,SNP,0.2μg)后可明显增加觉醒时间,缩短睡眠时间;微量注射一氧化氮合酶抑制剂L-硝基精氨酸(L-arginine,L-NNA,2.0μg)后,引起睡眠时间增多,觉醒时间减少。2.2大鼠RT内同时微量注射L-NNA(2.0μg)和SNP(0.2μg)后与L-NNA组比较发现SNP逆转了L-NNA的促睡眠作用;RT内同时微量注射L-NNA(2.0μg)和L-Arg(0.5μg)后,与L-NNA(2.0μg)组比较发现L-Arg可以增加觉醒而缩短睡眠,其促觉醒作用未能被NOS的抑制剂L-NNA所逆转。3 RT内阿片肽对大鼠睡眠-觉醒周期的影响3.1大鼠RT内微量注射硫酸吗啡(morphine sulfate,MOR,1.0μg)后与生理盐水组对比,睡眠时间减少而觉醒时间增加; RT内微量注射阿片肽受体拮抗剂盐酸纳洛酮(naloxone hydrochloride,NAL,1.0μg)后与生理盐水组比较,睡眠时间增加而觉醒时间减少。3.2大鼠RT内同时微量注射MOR(1.0μg)和NAL(1.0μg)后,与生理盐水组对比,原有的MOR促觉醒效果和NAL的促睡眠效果都没有表现。4 RT内环一磷酸腺苷信使对大鼠睡眠-觉醒周期的影响大鼠RT内微量注射cAMP(1.0μg)后与NS(1.0μg)组比较,睡眠时间增多而觉醒时间减少;RT内微量注射亚甲蓝(methylene blue,MB,1.0μg)后,与NS组比较,睡眠时间增多而觉醒时间减少。5中缝背核投射到丘脑网状核的5-羟色胺能神经纤维对大鼠睡眠-觉醒周期的影响5.1大鼠DRN内微量注射L-Glu(0.2μg),同时在双侧RT内微量注射NS (1.0μg)后,与对照组(DRN和双侧RT注射NS, 0.2μg)比较,睡眠时间减少,觉醒时间增多;大鼠DRN内微量注射L-Glu(0.2μg),同时在双侧RT内微量注射二甲基麦角新碱(methysergide, MS, 1.0μg )后,与对照组(DRN注射L-Glu 0.2μg,双侧RT注射NS 1.0μg)比较,睡眠时间增多,觉醒时间减少。5.2大鼠DRN内微量注射对氯苯丙氨酸(p-chlorophenylalanine,PCPA,10μg),同时在双侧RT内微量注射NS (1.0μg)后,与对照组(DRN和双侧RT注射NS, 1.0μg)比较,睡眠时间增多,觉醒时间减少;大鼠DRN内微量注射PCPA(10μg),产生睡眠增多效应后,在双侧RT内微量注射5-羟色胺酸(5-hydroxytryptaphan , 5-HTP, 1.0μg )后,与对照组(DRN注射PCPA 10μg,双侧RT注射NS 1.0μg)比较,睡眠时间减少,觉醒时间增多。
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Rock Around The Clock One, two, three o'clock, four o'clock, rock Five, six, seven o'clock, eight o'clock, rock Nine, ten, eleven o'clock, twelve o'clock, rock We're gonna rock around the clock tonight Put your glad rags on and join me, hon We'll have some fun when the clock strikes one We're gonna rock around the clock tonight We're gonna rock, rock, rock,'til broad daylight We're gonna rock, gonna rock, around the clock tonight When the clock strikes two, three and four If the band slows down we'll yell for more We're gonna rock around the clock tonight We're gonna rock, rock, rock,'til broad daylight We're gonna rock, gonna rock, around the clock tonight When the chimes ring five, six and seven We'll be right in seventh heaven We're gonna rock around the clock tonight We're gonna rock, rock, rock,'til broad daylight We're gonna rock, gonna rock, around the clock tonight When it's eight, nine, ten, eleven too I'll be goin' strong and so will you We're gonna rock around the clock tonight We're gonna rock, rock, rock,'til broad daylight We're gonna rock, gonna rock, around the clock tonight When the clock strikes twelve, we'll cool off then Start a rockin' round the clock again We're gonna rock around the clock tonight We're gonna rock, rock, rock,'til broad daylight We're gonna rock, gonna rock, around the clock tonight
罗克 Around 钟一,二,三点钟,四点钟,岩石五,六,七点钟,八点钟,岩石九,十,十一点钟,十二点钟,岩石我们正去向昼夜不停今晚的岩石穿上你的最好的衣服和加入我,亲爱的我们将获得乐趣中的一些当钟用击打我们正去今晚昼夜不停摇动的的时候,我们正去岩石,岩石,岩石,鼻音化符号大白天我们正去向去昼夜不停今晚的岩石的岩石当钟响了二,三和四下,如果乐队让生活松弛些的时候,我们将为我们正去今晚昼夜不停摇动的更多对叫嚷我们是去岩石,岩石,岩石,鼻音化符号大白天我们正去去的岩石向昼夜不停今晚的岩石当排钟正确在第七天堂中按五,我们将是的六和七叫的时候,我们正去向昼夜不停今晚的岩石我们正去岩石,岩石,岩石,鼻音化符号大白天我们正去向去昼夜不停今晚的岩石的岩石当它也是八,九,十,十一的时候,我将强有力地是 goin 和那样你希望我们是去昼夜不停今晚的岩石我们正去岩石,岩石,岩石,鼻音化符号大白天我们正去向去昼夜不停今晚的岩石的岩石当钟给予十二我们将使冷下来的时候,那时再次以开始一 rockin' 昼夜不停我们是去昼夜不停今晚的岩石我们正去岩石,岩石,岩石',鼻音化符号大白天我们正去向去昼夜不停今晚的岩石的岩石
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objective to study the correlation among psychosomatic health factors,depression,anxiety and sleep status in college students,to analyze influence factors in sleep status.methods with questionnaire opened in-vestigation,200college students were evaluated using cornell medical index,self-rating depression,self-rating anxiety scaleand pittsburgh sleep quality index.stepwise regression analysis was used.re-sults total score of sds was35.55±7.8,and sas was0.48±0.9.each score of cmi was higher than normal range,the highest was digestion system,next was respiration system,then,fatigue,eyes and ears,anxiety,sensitivity,tension,maladjustment in turn.total average score of psqi was6.32±3.6,ordinary sleep were115cases(57.5%),good and bad sleep were42(21%)and43(21.5%)cases respectively.influence factors in total score of psqi were sas,cmi,respiration system,anxiety,past healthy,digestion system,fatigue,sensitivity,sds and malad-justment in turn,using stepwise regression analysis,total score of psqi as dependent variable,each factor score of cmi,total score of sds and sas as independent variables.conclusion problems of psychosomatic health,anxiety and depression could both lead to sleep disorder.
目的 研究在校大学生心身健康因素及抑郁焦虑等与睡眠状况的相关性,并对影响睡眠状况的有关因素进行分析。方法采用问卷式的开放性研究,对在校的200名大学生进行康奈尔心身健康问卷、自评抑郁量表、焦虑自评量表和匹兹堡睡眠质量量表的测定,采用逐步回归分析方法。结果 sds总分为35.55±7.8、sas总分为0.48±0.9,cmi评分:消化系统最为严重评分为2.52,其次为呼吸系统、疲劳感、眼和耳、焦虑、敏感、紧张、不适应等,评分均高于正常常模。psqi总均分为6.32±3.6,一般睡眠有115例占57.5%,睡眠质量较好42例占21.0%,睡眠质量较差43例占21.5%。评估对睡眠状况的影响程度,以psqi总分为因变量,选择cmi各因子分和sds、sas总分作为自变量,进行多因素逐步回归分析,进入方程的因素依据标准化偏回归系数,影响psqi总分的因素依次为sas总分、cmi总分、呼吸系统、焦虑、既往健康、消化系统、疲劳感、敏感、sds总分、不适应(f=226.8;p.01;r=0.73)。结论心身健康问题和焦虑抑郁可导致睡眠障碍。
- 更多网络解释 与sleep around相关的网络解释 [注:此内容来源于网络,仅供参考]
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sleep around:乱伦
sleekly 光滑地 | sleep around 乱伦 | sleep in 睡过头
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sleep around:和几个人厮混
give somebody enough rope to hang himself 放任某人使其自取灭亡 | sleep around 和几个人厮混 | be taken for a ride 让人玩弄
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sleep around:性生活随便
194. Do you want to do it? 你想做吗? | 195. sleep around 性生活随便 | 196. She sleeps around a lot. 她是个喜欢随便和人上床的女人.
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sleep around:[俚](指女人)到处乱搞男女关系
walk in one's sleep 梦游 | sleep around [俚](指女人)到处乱搞男女关系 | sleep away 在睡眠中打发日子; 用睡眠来消除
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I like to sleep around:我喜欢到处拈花惹草
You're preaching to the converted.|我跟你意见一致 | I like to sleep around...|我喜欢到处拈花惹草 | whisk somebody off to Rio if the mood strikes me.|我需要有人陪我到里约热内卢
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