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Results The DNA was obtained from PPJ through a nasopancreatic tube. Aberrant p16 methylation and K- ras gene mutation were detected in the same samples of PPJ. Sensitivity,specificity,positive predictive values,negative predictive values and accuracy of HE staining for pancreatic cancer were 40%,100%,100%,45.4% and 60.0%,respectively. Of the 20 cases of pancreatic cancer,K- ras gene mutation was detected in 14 (70%) and the p16 gene was shown to be methylated in 7 (35%). Of the 8 cases of chronic pancreatitis,K-ras gene mutation was detected in 2 (25%). Of the 2 cases of mucinous cystoadenoma of pancreas,K-ras gene mutation was detected in 1 (50%). Aberrant methylation of p16 was not detected in pancreatic juice samples from patients with chronic pancreatitis and mucinous cystoadenoma of pancreas.
结果 所有胰液标本均成功抽提出DNA,30例胰腺疾病病人胰液标本同时进行了K-ras基因突变和p16基因启动子区5′CpG岛甲基化检测,其中20例胰腺癌病人胰液中K-ras基因突变率为70%(14/20),p16基因甲基化率为35%(7/20),8例慢性胰腺炎中K-ras基因突变率为25%(2/8),2例胰腺囊腺瘤病人中K-ras基因突变率为50%(1/2),慢性胰腺炎和胰腺囊腺瘤病人胰液中无p16基因甲基化。
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Result:22 out of 40(55%) primary tumors were detected the point mutations in the coden 12th of k-ras an d n-ras,h-ras.The point mutations of p53 E5 and E7 were found in 16 laryng eal tumors (16/40,40%).
结果:H-ras基因突变9例,突变率为22 。5%(9/40);K-ras基因突变8例,突变率为20%(8/40),N-ras基因突变5例,突变率为12.5%(5/40)。p53基因第5外显子突变7例,突变率为17.5%(7/40);第7外显子突变9例,突变率为22 。5%(9/40)。5例发现有两种基因突变,且均表现为ras基因和p53外显子改变。
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Objective To investigate the point mutation of codon 12 of H-ras and K-ras in tissues of gastric carcinoma.
目的 探讨人胃癌组织中H-ras、K-ras基因第12密码子点突变情况及意义。
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RAS:远程访问服务
于强壮的红外通讯的"红外线数据协会"(IrDA)传输层用于串行连接网络的"点对点协议"(PPP)和"串行线路接口协议"(SLIP)通过网络驱动程序接口规范(NDIS)支持局域网通过调制解调器对远程文件系统连接的"远程访问服务"(RAS)客户
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RAS:网状活化系统
这种活化作用是通过位于人脑根部的被称为网状活化系统(RAS)的次皮下单元的刺激而产生的. 通过一些装置就可以测量出人的活化作用水平,并以此为依据量化其情感警觉的程度,这样就完成了对感觉的测量.
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RAS:网状激活系统
激动的症状包括极度的警觉、心脏剧烈跳动、呼吸加深、出汗、口干等等. 激动的症状受自主神经系统(ANS)与网状激活系统(RAS)控制. ANS分布于全身,它有着身体"管家"的功能,例如心率.
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RAS:远程接入服务器
采用VoIP技术要注意以下几方面:充分了解现有的几种VoIP网关设备(独立网关、路由器网关、远程接入服务器(RAS)网关、IP PBX网关),统计出每种设备可处理的呼叫数量;检测每种设备的编码方式、压缩方法、优先级排序方式;
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RAS:abbr. the rennin-angiotensin system; 肾素-血管紧张素系统
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