quinolinic
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Alzheimer′s disease animal models were made by damaging bilateral nucleus basalis of Meynert of elderly rats (20-22 month) with quinolinic acid(150 nmol in 2 μL for each NBM, given d 3 after administration of test drugs). Activity of choline acetyltransferase was measured by radiochemistry assay. One time training passive avoidance step-down and water-maze spatial localization task were used to observe effects of ginsenoside of stem and leaf in combination with choline on learning and memory of AD model rats.
应用喹啉酸(每侧150 nmol,2 μL,给受试药后d 3注射)损毁老年大鼠双侧Meynert基底核制备阿尔茨海默病动物模型,放射化学法测定胆碱乙酰基转移酶活性,一次性训练被动回避跳台实验和水迷宫空间分辨能力测试,观察人参茎叶皂甙和胆碱合用对AD模型大鼠学习记忆的影响。
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Objective To explore into the probable mechanism of Alzheimer's diseaseby the acupuncture treatment combined with DGSYS of TCM.Methods Three kinds of model rats with dysmnesia which were made by injected into drug of scopolamine or NaNo 2 in the abdomen separately and injured at the hippocampal CA 1 in brian by drug of quinolinic acid treated by single acupuncture or acupuncture combined with DGSYS of TCM or DGSYS of TCM were observed separately,to compare different influence on dysfunctions of acuquisition and consoli-dation of memory induced by drugs and injure with nimodipineor the normal rats.
通过腹腔注射药物东莨菪碱或亚硝酸钠,或者用奎宁酸损毁大脑海马CA 1 区诱发大鼠发生记忆力障碍,造成不同类型的大鼠&痴呆&模型,对照性观察针刺、针刺加DGSYS、DGSYS及NM对记忆障碍功能的影响和与记忆相关实验指标参数的变化。
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Li Zhongren,Shen Meihong,Mu Yanyun,et al.Nanjing University of TCM,Jiangsu210029. Objective To explore into the probable mechanism of Alzheimer's diseaseby the acupuncture treatment combined with DGSYS of TCM.Methods Three kinds of model rats with dysmnesia which were made by injected into drug of scopolamine or NaNo 2 in the abdomen separately and injured at the hippocampal CA 1 in brian by drug of quinolinic acid treated by single acupuncture or acupuncture combined with DGSYS of TCM or DGSYS of TCM were observed separately,to compare different influence on dysfunctions of acuquisition and consoli-dation of memory induced by drugs and injure with nimodipineor the normal rats.
目的 探索临床针刺加当归芍药散治疗阿尔采默氏症的可能机理方法通过腹腔注射药物东莨菪碱或亚硝酸钠,或者用奎宁酸损毁脑海马CA 1 区诱发大鼠发生记忆力障碍,造成不同类型的大鼠&痴呆&模型,对照性观察针刺、针刺加DGSYS、DGSYS及NM对记忆障碍功能的影响和与记忆相关实验指标参的变化。
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High quinolinic acid levels in the brain are thought to be the cause of the dementia seen with HIV infection.
高喹啉酸水平在大脑中被认为是造成痴呆看到感染了艾滋病毒。
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Investigate the efftects of exogenous quinolinic acid on acute and subacute animal models of inflammation.
研究外源性给予喹啉酸对动物急性和亚急性炎症模型的影响。
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quinolinic acid:喹啉酸
本实验采用喹啉酸(quinolinic acid)损毁老年大鼠Meynert基底核(nucleus basalis of Meynert,NBM)制备AD动物模型[5],旨在此基础上观察人参皂苷Rg1对AD学习记忆障碍的改善作用.
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quinolinic anhydride:喹啉[酸]酐
喹啉;苯并吡啶 quinoline | 喹啉酸;2,3-吡啶二甲酸 quinolinic acid; pyridine-2,3-dicarboxylic acid | 喹啉[酸]酐 quinolinic anhydride
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quinolinic acid; pyridine-2,3-dicarboxylic acid:喹啉酸;2,3-吡啶二甲酸
喹啉;苯并吡啶 quinoline | 喹啉酸;2,3-吡啶二甲酸 quinolinic acid; pyridine-2,3-dicarboxylic acid | 喹啉[酸]酐 quinolinic anhydride