quercetin ['kwə:sitin]
- quercetin的基本解释
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n.
橡黄素
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- quercetin rutinoside
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Results:①The amount of human colon carcinoma cell line SW480 treated by quercetin decreased. The morphology of partial SW480 cells was shrunk volume, integrated cell membrane, condensed cytoplasm, pyknotic chromatin, nuclear fragmentation. Apoptotic Corpuscles were found by electron microscope.②MTT colorimetric assay showed quercetin inhibited the growth of human colon carcinoma cell line SW480 in a time- and dose-dependent manner when the concentration of quercetin was 30、60、90μmol/L.③Flow cytometry analysis showed the cell cycle of SW480 cell was restricted in G1/S. G0/G1 phase rate increased and S phase rate decreased with increasing concentration of quercetin and time lasting.④ Zymogram analysis assay showed the secretion of matrix metalloproteinases in human colon carcinoma cell line SW480 treated by quercetin decreased. With increasing concentration of quercetin, the secretion of MMP-2 and MMP-9 decreased.⑤Immunohistochemistry method demonstrated the position expression of Cathepsin-D in SW480 cell was suppressed by quercetin in a time- and dose-dependent manner.
研究结果:经槲皮素处理的人结肠癌SW480细胞数量减少,部分细胞体积缩小,细胞膜完整,胞浆浓缩,核染色质固缩,细胞核碎裂,形成凋亡小体;MTT法检测显示当作用浓度为30μmol/L~90μmol/L时,槲皮素对人结肠癌SW480细胞的生长有抑制作用,其抑制作用随着作用浓度的增加和作用时间的延长而增强;流式细胞学发现槲皮素主要作用于人结肠癌SW480细胞周期的G1/S期,大部分细胞被阻断于S期,随药物浓度的升高和作用时间的延长,G0/G1期细胞比例逐渐增加,S期细胞比例逐渐减少;酶谱分析法检测显示不同浓度的槲皮素能够抑制人结肠癌SW480细胞分泌MMP-2及MMP-9,随浓度的升高,MMP-2及MMP-9的分泌量减少;免疫组织化学法显示不同浓度的槲皮素处理人结肠癌SW480细胞后,Cathepsin-D的表达随药物浓度的升高和作用时间的延长而降低。
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Quercetin, quercetin rhamnoside, hyperin, syringoside and eleutheroside E wereisolated from the flower of Acanthopanax senticosus. Searching bioactive natural compound and establishing quality evaluation standard arefocused on this experiment. Using cold immersing of 70% methanol to extract from flower ofAcanthopanax senticosus and integrating macroporous resin, silica gel column chromatography,sephadex gel to abstract. We obtained five monomer compounds (compoundⅠ-compoundⅤ),quercetin, quercetin rhamnoside, hyperin, syringoside and eleutheroside E. That five compoundswere determined by HPLC in eight parts of Acanthopanax senticosus (flower, root, leaf fruit,shoot, new shoot, phloem of shoot, skin of shoot), which provide science bases for establishingquality evaluation system and settle infarctate foundation.
本文以从刺五加花蕾中寻找具有重要生物活性的天然化合物和建立质量评价标准为主要目的,对其化学成分进行研究,采用70%甲醇冷浸的方法对刺五加花蕾中的成分进行提取,运用大孔树脂吸附色谱法、硅胶柱层析法以及葡聚糖凝胶柱层析相结合的方法进行分离,得到5种单体化合物,分别为槲皮素、槲皮素鼠李糖苷、金丝桃苷、紫丁香苷和刺五加苷E;利用高效液相色谱法对这5种化合物在刺五加花蕾中的含量进行了测定;考察了8个部位(花蕾、根、叶、果、茎干、新枝、茎韧皮部、茎皮)中这5种化合物的含量分布情况,并作一比较,为今后建立刺五加质量评价体系提供了科学依据,奠定了坚实的基础。
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On the basis of spectral analysis, these compounds were identified as Kaempferol , Kaempferol-3-O-β-D-glucopyranoside , Kaempferol-3-O-β-D-galactopyranoside, Quercetin , Quercetin-3-O-β-D-arabinopyranoside, Quercetin-3-O-β-D-galactopyranoside, gallic acid, methyl gallate-4-O-β-D- galactopyranoside, caffeicacid, methyl caffeate, 4-cafeoyl-(3"a, 4"a, 5"β)- trihydroxyquinic acid, 3"-cafeoyl-(3"a, 4"P, 5"P )-trihydroxyquinic acid methyl ester, 5"-cafeoyl-galactonic acid , pumiloside, loganic acid , 5R,6S,7E-megastima-3-on-7-en-9-ol 9-O-β-D-glucopyranoside. 2a, 3β-dihydroxy-oleanoic acid , 2a, 3β, 23-trihydroxy-oleanoic acid, 3a, 6a-dihydroxy-oleanoic acid, 3β-hydroxy-ursoic acid, 2a, 3a, 23-trihydroxy-ursoic acid , 2a, 3β, 23-trihydroxy-ursoic acid, 2β, 3β, 19a -trihydroxy-ursoic acid, 2a , 3β, 19a -trihydroxy-ursoic acid-28-O-β-D-glucopyranoside , 2a. 3a, 19a-trihydroxy-ursoic acid-28-O-β-D-glucopyranoside, 2a, 3a, 19a, 23-tetrahydroxy-ursoic acid, 1a, 3a, 19a, 23-tetrahydroxy-ursoic acid-28-O-β-D-glucopyranoside , 3a, 19a, 23-trihydroxy-ursoic acid.
从珙桐中分离鉴定得到了28种化合物,它们分别是:山奈酚,3-O-β-D-吡喃葡萄糖基-山奈酚甙,3-O-β-D-吡喃半乳糖基-山奈酚甙,槲皮素,3-O-β-D-吡喃阿拉伯糖基-槲皮素甙,3-O-β-D-吡喃半乳糖基-槲皮素甙,没食子酸,4-O-β-D-吡喃半乳糖基-没食子酸甲酯,咖啡酸,咖啡酸甲酯,4-咖啡酰基-(3&α,4&α,5&β)-三羟基鸡纳酸,4-咖啡酰基-(3&α,4&β,5&β)-三羟基鸡纳酸甲酯,5'-咖啡酰基-半乳糖酸,pumiloside,loganic acid,5R,6S,7E-megastima-3-on-7-en-9-ol9-O-β-D-glucopyranoside,2α,3β-二羟基齐墩果酸,2α,3β,23-三羟基齐墩果酸,3α,6α-二羟基齐墩果酸,3β-羟基熊果酸,2α,3α,23-三羟基熊果酸,2α,3β,23-三羟基熊果酸,2β,3β,19α-三羟基熊果酸,2β,3β,19α-三羟基熊果酸-28-O-β-D-吡喃葡萄糖甙,2α,3α,19α-三羟基熊果酸-28-O-β-D-吡喃葡萄糖基甙,2α,3α,19α,23-四羟基熊果酸,2α,3α,19α,23-四羟基熊果酸-28-O-β-D-吡喃葡萄糖基甙,3α,19α,23-三羟基熊果酸。
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Quercetin:槲皮素
先前的研究显示: 槲皮素(quercetin)会很快地被肠及肝代谢掉,因此很难在血液里发现他. 研究团队因此先前的研究显示: 槲皮素(quercetin)会很快地被肠及肝代谢掉,因此很难在血液里发现他.先前的研究显示: 槲皮素(quercetin)会很快地被肠及肝代谢掉,
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Quercetin:槲皮苷
杏含有非常丰富的类胡萝卜素. 它不仅促进皮肤的再生,而且还能预防动脉中的沉积和增强免疫系统. 两只杏足以满足日需量. 另一好处黄酮类化合物槲皮苷(Quercetin)具有抗菌作用. 增强免疫系统,预防动脉硬化.
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Quercetin:橡黄素
四、增加饱感-苯丙氨酸(Dl-Phenylalanine)作用淤中枢神经来增加饱腹感和降低食欲,加酪氨酸(Tyrosine)能提高脑内的Dopamine及肾上腺素和副肾上腺素的前导物质,有助降低食欲. 六、增加抗氧化功能--橡黄素(Quercetin)能帮助消除游离基(Free Radicals)和提高代谢功能,刺激消化系统提高活动力.
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Quercetin:槲黄素
E生物类黄酮复合物-- 镁 (Magnesium)、维他命C(抗坏血酸) (Vitamin C)、凤梨酵素 (Bromelain)、槲黄素 (Quercetin)槲黄素是非常有效的抗发炎剂,槲黄素能阻止更强的发炎物质:白三烯素(leukotrienes)的释出,
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Quercetin:abbr. qu; 槲皮素
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