presymptomatic

presymptomatic的基本解释

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症状发生前的

与presymptomatic相关的网络例句 [注：此内容来源于网络，仅供参考]

①Location of WD gene in Ch inese: Using pairwise linkage analysis and multipoint linkage analysis method, w e constructed a genetic map of DNA markers within D13q14.2-3 which refined the location of WD gene by restriction fragment length polymorphism and microsatellite polymorphism analysis;②Screen for mutations of WD gene in Chinese people: we detected the structure of 21 exons of WD ge ne in 45 patients from 39 pedigrees by PCR-SSCP(Single strand conformation poly morphism) and PCR-DNA sequencing technology, found a new mutation in exon 5 and nuclcotide sequence analysis showed it is a T insertion. We also conformed the Arg778Leu in exon 8, the highest frequence mutation point in Chinese people, wit h mutation rate 22.8%in total;③Carrier detection and presymptomatic diagnosi s of WD: Based on DNA recombination technology, we peformed successfully the gen e diagnosis in all individuals of 79 families with WD and built up a helpful spe cific enzyme cut method (PCR-Msp1) to detect the carrier and presympomatic patients in Chinese pe ople with WD.

①WD的基因定位研究：通过RFLP及微卫星多态性分析，应用两位点及多位点连锁软件，建立了中国人WD基因在D13q14.2-3区域的精细遗传连锁图谱，从而首次对中国人WD基因进行了精确定位；②WD基因突变研究：应用PCR-SSCP及DNA测序技术，对39个家系45名WD患者进行该致病基因的21个外显子突变筛选，发现WD基因5号外显子存在新的T插入突变，并证实中国人WD基因的突变热点为8号外显子，突变形式为Arg778Leu，其频率为22.8%；③WD的症状前诊断和杂合子检出：应用DNA重组技术对79个家系进行基因诊断，成功地进行了WD的症状前诊断和杂合子检出，并建立了WD的基因筛选的PCR-Msp 1酶切方法。

Clinical trials in humans would be very difficult, however, because trials require many participants and there is no easy way to score effectiveness of a presymptomatic drug, Dr.

临床试验中，在人类将是非常困难的，但是，由于审判需要许多与会者并没有简单的方法来评分效力的presymptomatic药物，博士bezprozvanny说。

In 109 individuals of 19 WD families, we found 8 presymptomatic patients, 10 carriers and 15 normal people, 3 could not be determined. The rate of gene diagnosis was 91.67%.

共检出8例症状前患者，10例致病基因携带者及15例正常人，3例未能确定，基因诊断率达91.67%。

Results In 3 presymptomatic patients, no clinical abnormalities were found. Among 28 patients with symptoms, 23 patients (82%) had their symptoms and signs subsided or much improved, 2 patients(7%) remained unchanged, and 3(11%) died.

结果 3例症状前期患儿未出现异常；28例有症状患儿中23例(82%)临床症状基本消失或明显好转，2例(7%)无改善，3例(11%)死亡。

In 109 individuals of 19 WD families,we founded 8 presymptomatic patients,10 carriers,14 normal people,4 could not determined,the rate of gene diagnosis was 88.87%.

共检出8例症状前患者，10例基因携带者及14例正常人，4例未能确定，基因诊断率达88.87%。

与presymptomatic相关的网络解释 [注：此内容来源于网络，仅供参考]

presymptomatic：症状发生前的

presuppression 预抑制 | presymptomatic 症状发生前的 | presynapsis 前联会

presymptomatic diagnosis：症状前诊断

基因诊断 gene diagnosis | 症状前诊断 presymptomatic diagnosis | 单卵双生 monozygotic twins,identical twins