prediagnostic
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In peripheral blood obtained up to 77 months before a CLL diagnosis, prediagnostic B-cell clones were present in 44 of 45 patients with CLL.
45例白血病患者中,44例在CLL诊断前77个月内获得的外周血中发现了诊断前B细胞克隆。
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RESULTS: On the basis of either flow-cytometric or molecular analysis, 44 of 45 patients with CLL (98%; 95% confidence interval , 88 to 100) had a prediagnostic B-cell clone; in 41 patients (91%; 95% CI, 79 to 98), the presence of the B-cell clone was confirmed by both methods. The presence of immunoglobulin heavy-chain variable genes was determined in 35 of 45 prediagnostic clones (78%).
结果:在流式细胞或分子分析的基础上, 45名白血病患者有44例(98 %; 95 %可信区间,88~100 )具有诊断前B细胞克隆;在41例( 91%; 95 %可信区间, 79~98 ),B细胞克隆的存在得到了这两种方法的证实。45个诊断前克隆中有35个(78%)具有免疫球蛋白重链可变基因。
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Objective: To investigate whether prediagnostic fasting glucose and insulin concentrations and insulin resistance are associated with subsequent incidence of exocrine pancreatic cancer in a cohort of male smokers.
目的:在一个男性吸烟人群队列中调查诊断前空腹血糖、胰岛素水平和胰岛素抵抗是否与外分泌型胰腺癌发生相关。
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Furthermore, 27 of 35 of the IGHV sequences (77%) had mutations, with similar distributions after stratification either below or above the median time between the collection of the prediagnostic blood sample and the subsequent CLL diagnosis.
此外,35个IGHV序列中有27个(77 %)有突变,对诊断前血液样本收集和随后CLL诊断的中位时间进行分层,突变具有类似的分布。
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Context: Obesity, diabetes mellitus, and glucose intolerance have been associated with increased pancreatic cancer risk; however, prediagnostic serum insulin concentration has not been evaluated as a predictor of this malignancy.
背景:肥胖、糖尿病、葡萄糖耐受不良与胰腺癌发生风险升高有关。然而,诊断前血清胰岛素水平并不能作为这种恶性疾病的预测指标。
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