peritonitic
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We previously demonstrated that intravenously administered arginine attenuates the inflammatory response, whereas the simultaneous administration of arginine and an NOS inhibitor, i.e., L-NMMA, might not improve hypermetabolic and inflammatory responses in peritonitic rats.
先前的实验证实,以静脉给予arginine可减缓腹膜炎大鼠的发炎反应,但同时给予arginine及NOS抑制剂未改善其高度代谢及发炎现象。
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We found that intravenously administered arginine significantly decreased the spleen weight, the serum interleukin-6 level, and IL-6 production by leukocytes, splenic macrophages, and thymocytes; significantly decreased tumor-necrosis factor-α production of leukocytes and thymocytes; and significantly increased the stimulating index of cell proliferation in T-thymocytes in peritonitic rats.
结果显示,静脉给予arginine显著降低腹膜炎大鼠脾脏重量、血清间白素-6、与白血球、脾脏巨噬细胞及胸腺细胞IL-6分泌量,且显著降低白血球与胸腺细胞肿瘤坏死因子-α分泌量,但显著增加胸腺细胞增生的刺激指数。