muscarine ['mʌskərin]
- muscarine的基本解释
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蕈毒碱, [化] 蝇蕈碱
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- muscarinic
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Objective: To study research analytical method of muscarine.
目的:研究探讨GC/MS测定毒蝇碱的分析方法。
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It was found that there were kinds of neurotransmitter receptors expressed in Xenopus oocytes besides native muscarine receptor in oocyte itself.
实验发现除卵母细胞本身所具有的muscarine受体外,还有多种受体明显地在卵母细胞上表达。
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Early chemists had mistakenly assumed that the psychoactive principal of Fly Agaric was to be found in a tropane alkaloid known as muscarine.
早期化学家误假定精神科主飞金顶是可以找到一个烷生物碱称为毒蕈碱。
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Results:①In normal extracellular solution, the non-selective cholinergic agonist acetylcholine and the muscarinic agonist muscarine both caused the increace of [Ca2+]i in separately 21 out of 25 and 14 out of 18 VHCs I, while only 3 out of 20 and 2 out of 16 VHCs I had a weak increase of [Ca2+]i if investigated in calcium free extracellular solution; nicotine could increase the [Ca2+]i in 7 out of 32 VHCsⅠonly at enough high concentration(up to 10 mmol/L) in normal extracellular solution, this [Ca~(2+)]_i increase by nicotine at high concentration could not be investigated if at calcium free solution.
结果①非选择性胆碱能受体激动剂乙酰胆碱、M型胆碱能受体激动剂毒蕈碱在正常细胞外液中均可引起大部分(21/25, 14/18)单离VHCⅠ[Ca~(2+)]_i的升高,但无钙外液中ACh、muscarine仅使少部分(3/20,2/16)VHCⅠ[Ca~(2+)]_i升高且作用减弱;正常外液中,N型受体激动剂尼古丁仅在高浓度(≥10 mmol/L)时引起部分(7/32) VHCⅠ[Ca~(2+)]_i升高,在低浓度时对胞内钙离子浓度影响不明显,无钙外液中,10 mmol/L nicotine对胞内钙离子浓度影响不明显。
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muscarine:毒蕈碱
1.毒草碱型受体 能与毒蕈碱(muscarine)特异性结合并被激动的胆碱受体称为毒草碱型受体(muscarinic receptor,M受体),主要位于节后胆碱能神经纤维所支配的效应器细胞膜上.
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muscarine:毒蝇碱
最初的成分报告见于1869年,但真正分离提纯出毒蝇碱(muscarine)是到了1954年由瑞士人C.H.Eugster完成的. 当时他利用1 250 kg蘑菇子实体得出纯毒蝇碱3~4 g(含量0.0003%),并鉴定出许多异构体(见图1). 其中,L-(+)-(2S,3R′,
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muscarine:蕈毒碱
再为乙酰胆碱合成所用.乙酰胆碱是内源性生物活性物质,具有重要而广泛的生理作用.由于天然生物碱蕈毒碱(Muscarine)和烟碱(Nicotine)作用于乙酰胆碱受体产生不同的生物活性,
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muscarine:毒蕈硷
其毒素为类似乙酰胆硷的毒蕈硷(muscarine). 潜伏期约1~6小时发病时临床表现除肠胃炎的症状外,尚有副交感神经兴奋症状,如多汗流涎、流泪、脉搏缓慢瞳孔缩小等. 用阿托品类药物治疗效果甚佳. 少数病情严重者可有谵妄幻觉、呼吸抑制等表现.
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muscarine antagonist:抗毒蕈碱剂
murmur 杂音 | muscarine antagonist 抗毒蕈碱剂 | muscarinism 蕈毒碱中毒
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