isoalantolactone
- isoalantolactone的基本解释
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异土木香内酯
- 更多网络例句与isoalantolactone相关的网络例句 [注：此内容来源于网络，仅供参考]
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OBJECTIVE: Three sesquiterpene lactones 1-O-acetylbritannilactone, isoalantolactone and britannilactone were isolated from the roots of Inula helenium and the flowers of Inula japonica. The antitumor activities of the three sesquiterpenoids in the cell lines of HeLa, HEC-1, SHIN3, HOC-21 and HAC-2 were measured, and the relationship between structure and activity and the possible mechanisms were explored.
目的： 观察菊科植物中分离出的3种倍半萜化合物异土木香内酯、1-氧-乙酰大花旋覆花内酯和大花旋覆花内酯对体外培养的人子宫颈癌HeLa细胞、人子宫内膜癌HEC-1细胞、人卵巢透明细胞癌SHIN3及HOC-21细胞和人卵巢囊腺癌HAC-2细胞增殖的影响，研究这3种倍半萜化合物的体外抑制肿瘤细胞增殖作用及其结构与活性之间的构效关系，进而探讨3种倍半萜化合物的体外抑制肿瘤细胞增殖的可能机制。
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Determination of alantolactone and isoalantolactone in herb Inula racemosa Hook.f.by RP-HPLC.
RP-HPLC测定藏木香中土木香内酯和异土木香内酯含量。
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RESULTS:Isoalantolactone exhibited excellent anti-proliferative activities on HeLa, SHIN3 and HOC-21 and HAC-2 cell lines, while 1-O-acetylbritannilactone and britannilactone demonstrated weak anti-proliferative activities on HeLa, SHIN3, HOAC-21 and HAC-2 cell lines even at the concentration of 100 μmol/L. The apoptotic rate in isoalantolactone group with the concentration of 12.5 μmol/L was higher than that in PBS group.
结果： 异土木香内酯对上述5种肿瘤细胞的增殖均有明显的抑制作用，1-氧-乙酰大花旋覆花内酯和大花旋覆花内酯即使在100 μmol/L的高浓度下，对5种妇科肿瘤细胞的增殖不显示抑制活性；流式细胞学检查发现异土木香内脂处理后的HeLa细胞出现凋亡现象。
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MTT assay indicated that anti-proliferative activities in HeLa, SHIN3, HOAC-21 and HAC-2 cell lines were closely related to structure, 1,10-seco of eudesmane sesquiterpene lactone resulted in reduced anti-proliferative activity. The anti-tumor activity of isoalantolactone was probably achieved by inducing HeLa cell apoptosis.
提示A-环开环可能是导致桉叶烷型倍半萜内酯的体外抑制肿瘤细胞增殖作用消失或减弱的原因；异土木香内酯抑制肿瘤细胞增殖作用有可能是通过诱导肿瘤细胞凋亡机制而实现的。
- 更多网络解释与isoalantolactone相关的网络解释 [注：此内容来源于网络，仅供参考]
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Isoalantolactone：异土木香内酯
Isoaconitine 紫草乌碱乙 | Isoalantolactone 异土木香内酯 | D-Isoascorbic acid D-异抗坏血酸
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Isoalantolactone：莪二酮(莪术二酮/姜黄二酮)
E004 N,N'-二甲基蝙蝠葛碱碘化物 N,N'-dimethyldauricine iodide | E005 莪二酮(莪术二酮/姜黄二酮) isoalantolactone | E006 莪术醇 Curcumol