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induction factor的中文,翻译,解释,例句

induction factor

induction factor的基本解释
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诱导因素, 诱发因素(子)

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Poptosis-inducing factor is a mitochondrion-localized flavoprotein with NADH oxidoreductase activity, which is encoded by the nuclear gene. Following induction of apoptosis, AIF is released from mitochondria and translocated to cytosol, and then to the nucleus. The mechanism of AIF translocation from mitochondria to nucleus is still unclear. It has been suggested that translocation is due to the presence of nuclear localization signal.

bstract: AIF(apoptosis-inducing factor)为位在粒线体内膜膜上之蛋白质,在正常细胞中,能够藉由维持电子传递链复合体I的稳定性,进而影响细胞能量的产生及自由基的清除,并且也会维持粒线体的构造;反之,当细胞遭受到不当刺激时,粒线体膜通透性改变,使得原本存在於粒腺体间质中之AIF,被释放出来,进入细胞核内造成DNA片段化,进一步促进细胞凋亡。

Abstract] AIM:To investigate the role of nuclear factor κB in the induction of iNOS gene by TNFα and LPS in endothelial cells and the effect of antioxidant on the induction of iNOS. METHODS:Nitrite was determined based on Griess reaction. iNOS mRNA was analyzed using Northern blot. NFκB in the cell nucleole was detected with electrophoretic mobility shift assay.RESULTS:(1)NO production and iNOS mRNA expression induced by LPS and TNFα was blocked by pyrrolidine dithiocarbamate or N-acetylcysteine.

研究表明内皮细胞激活时iNOS表达的调控主要发生在转录水平。iNOS基因的启动子区域含有多个转录因子的结合位点包括NFκB、AP-1、NF-IL6,Oct-1等[2],而核因子κB(nuclear factor κB, NFκB)被认为在多种参与炎症反应的蛋白质因子的基因调控中担任重要角色,因而可能是内皮细胞激活的调控中一个重要转录激活因子[2,3]。

Systemic levels of IL-6, IL-8 and TNF- a increase in patients with acute pancreatitis and correlate with the severity of the disease.A key regulator of cytokine induction is the pleiotropic transcription factor nuclear factor- K B.

核因子-κB(nuclear factor-kappa B,NF-κB)是由Rel蛋白家族成员形成的同源或异源二聚体,它几乎存在所有的细胞,不同的二聚体与不同的DNA序列结合,亲和力和转录激活能力是不一样的。

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saturation factor:饱和率

saturation curve 饱和曲线 | saturation factor 饱和率 | saturation induction 饱和感应