epigenetically
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In this way, histone modifications have the potential to influence many fundamental biological processes, some of which may be epigenetically inherited.
在这种方法中,组蛋白修饰具有影响很多基本生物学过程的潜力,它们中的一些可能是表观上遗传的。
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In other words, researchers have to prove that the disruption of this function, either genetically through mutation, or epigenetically through DNA methylation or chromatin modification, causes the initiation or progression of cancer.
换句话说,研究人员必须证明这些功能的中断,或者是通过遗传上的突变,或者是通过表观上的DNA甲基化或染色质修饰,导致癌症的发生以及进一步恶化。
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Analysis of five other epigenetically repressed genes indicates that Ras directs the silencing of multiple unrelated genes through a largely common pathway.
分析另外5个表观抑制基因显示Ras通过一个主要的共有通路指导多相关基因的沉寂。
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They identified 371 genes (nearly 10%) as monoallelically expressed in epigenetically stable patterns in at least one population of cells derived from a single B cell clone.
他们确认起源于一个单B细胞克隆种群的371个基因(近10%)以单等位基因性在后生遗传稳定模式中表达。
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Gimelbrant et al. determined the proportion of human genes that can be expressed monoallelically, in patterns that are epigenetically stable (for example, chemical modifications of DNA, such as cytosine methylation, that do not alter the sequence but are heritable within cell populations).
Gimelbrant等确定部分人类基因,能够单等位基因性表达,在表达模式上,后生同类物稳定(例如,化学修饰的DNA ,如胞嘧啶甲基化,不改变序列,但内细胞群是可遗传的)。
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