deguelin [di'gelin]
- deguelin的基本解释
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鱼藤素
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The study was purposed to investigate the effect of deguelin on expression of nucleoporin 98(nup98) in leukemia K562 cells.
本研究观察鱼藤素对白血病细胞株K562细胞核孔蛋白nup98表达的影响。
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Results:(1) The proliferation of Jurkat cells was inhibited by deguelin in a time- and dose-dependent manner, with IC50 value for 24 h being 46.03±0.13 nmol/L.
2鱼藤素以剂量依赖性方式诱导Jurkat细胞凋亡，40 nmol/L的鱼藤素处理24 h后出现明显的DNA剪切现象，伴有典型的凋亡细胞形态学改变，其总凋亡率达(19.87±1.76)%。
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Effects of deguelin on the regulation of nucleoporins and nucleophosmin in Jurkat leukemia cells in vitroObjective: To study the antileukemia effects of deguelin on leukemia cells, and explore the possible mechanisms to provide more theories for clinical application.
第一部分鱼藤素对Jurkat白血病细胞核孔蛋白与核磷蛋白的调节作用目的：研究鱼藤素对白血病细胞增殖和凋亡的影响，并探讨其可能的作用机理，为其临床应用提供理论基础。
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Deguelin induced DNA fragmentation and apoptotic cell death in a dose-dependent manner, which was accompanied by typical morphological changes associated with apoptosis.
3鱼藤素能同时在蛋白和基因水平，以剂量依赖性方式抑制核孔蛋白Nup88、Nup214以及核磷蛋白NPM的表达。
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Objective To investigate antitumor activity and molecular mechanism of deguelin to the human U937 leukaemia cells and to explore the mechanisms regulating cell cycle and nucleoporin 98 （Nup98） and nucleoporin 88 （Nup88） in vitro.
目的研究鱼藤素对人类白血病细胞株U937细胞体外抗肿瘤作用，研究其引起细胞周期与核孔蛋白Nup98和Nup88的改变，探讨其抗癌作用的分子机制。
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deguelin：鱼藤素
鱼藤素研究进展 纪伟,陈仁娟,崔玉兰,周庆新,林新仁,*甘纯玑 福建农林大学食品科学学院,福州(350002) 摘要:鱼藤素(Deguelin)是一种黄酮类化合物,存在于毒灰叶(Tephrosia toxicaria)、鱼藤(Derris trifoliata)和毕澄茄(Pipe cubeba)的根中,