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A virus strain was isolated from the arthrosis of broiler chickens.The virus was shown to have spherical particles with isometric symmetry,no envelope,double deck capsids,with outer capsid of 75nm,inner one of 50nm in diameter by electron microscopy.The virus was not sensitive to aether,acid and heat.The virus could multiply on the chick embryo fibroblastcell,and could cause syncytial pathologic change with the appearance of cytoplasm inclusion bodies.The challenged chickens of one-day old by nasal,oral,intramuscular and pulvillus injection displayed obvious clinical symptom of severe arthritis and accompanied with pathological changes of malabsorption and necrosis.Meanwhile,four avian reovirus isolates CL,S1133,YH and YB were examined in the cross-neutralization test.
从临床患病鸡关节病料中分离到一株病毒,在电镜下观察到病毒粒子无囊膜,有双层衣壳,外衣壳直径约75nm,内核约50nm;分离病毒株对酸、热有较强的抵抗力,对乙醚不敏感;病毒感染鸡胚成纤维细胞上能产生以融合细胞为特征的CPE;爪垫接种1日龄雏鸡表现出明显的病毒性关节炎临床症状,并伴有吸收障碍型和坏死型的病理变化;血清中和交叉试验表明,该病毒分离株与国内的2株番鸭源呼肠孤病毒分离株和国外S1133呈不同程度的交叉反应。
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Retroviruses use a similar set of components to seal off their RNA in structures called capsids.
逆转录病毒利用相似的成分包装他们的RNA,在病毒结构上成为衣壳。
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He SPRY domain of TRIM5α, which may be responsible for recognition of incoming viral capsids showed higher nonsynonymous/synonymous substitution ratios than the non-SPRY domain, indicating that the adaptive evolution of TRIM5α in primates might be an innate strategy developed in defending retrovirus infection during primate evolution.
RIM5α的 SPRY 结构域可能负责识别入侵病毒的衣壳,这个结构域比基因的其它部分在进化过程中具有更高的错义突变同义突变比率,表明 TRIM5α的适应性进化可能是灵长类发展抗反转录病毒感染策略的结果。
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The results provide a basis for research of the assembly of FMDV empty capsids in vitro and the design of antivirus drug.
本研究为空衣壳的体外组装及新型抗病毒药物设计的研究奠定了基础。
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The strains differ most in the molecular structure of the proteins in their capsids.
各种鼻病毒株之间差异最大的其病毒外壳的蛋白质分子结构。
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