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Progesterone increased the formation of the CDK2-p21 and CDK2-p27 complexes, but not the CDK4-p21 and CDK4-p27 complexes. Moreover, the assayable CDK2, but not CDK4, activity was concentration-dependently decreased by progesterone treatment.
藉由同时给予p21与p27反义寡核苷酸造成p21与p27的表现被抑制,会回复助孕酮所产生之胸腺嘧啶核甘标记嵌合([3H]thymidine incorporation)的抑制。