aspartyl
- aspartyl的基本解释
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[机] 门冬氨酰, 丁氨二酰
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The better reaction conditions are as follows: Reaction temperature is 40°C, Reaction time is 5 hour; the ratio of L - phenylalanine to acetic acid and N - formyl - L- aspartyl anhydrideis 1:10.2:1.1, Its yield is 95.4%.
在查阅文献的基础上,得到较优的α-L-天冬氨酰L-苯丙氨酸甲脂盐酸盐的合成方案,在甲醇一水体系中,N-甲酰-α-L-天冬氨酰-L-苯丙氨酸在浓盐酸的作用下60℃水解90分钟,后冷却到15℃加入浓盐酸在20~30℃保温反应96小时,进行甲脂化,形成甲脂盐酸盐,结晶析出。
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Recently,numerous studies proved that each member of secreted aspartyl proteinase have different requirements in temperature and pH,with develop of gene mutation technology further cleared relation between gene expression regulation and organism′s infection sites and state,as well as transcription activation factor effect on expression of each member of secreted aspartyl proteinase.
近年来,大量研究证实了分泌型天冬氨酸蛋白酶各成员对温度、pH值等培养方面有不同的要求,基因突变技术的发展,进一步明确了基因表达调控与机体感染部位、感染状态之间的关系及转录活化因子在蛋白酶各成员表达中的作用。
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One of the major problems,however,remains the poor solubility and membrane permeation of pepstatin, as well as its lack of selectivity among aspartyl proteases.The amino acid statine can mimic the tetrahedral transition-state of amide bond hydrolysis but cannot itself be hydrolyzed by the enzyme.
分子中含有两个非天然氨基酸statine能模拟天冬氨酸蛋白酶底物活性部位的四面体水解过渡态,且本身不易被切割,通过氢键和酶的天冬氨酸残基结合。
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Pepstatin,which contains the novel amino acid statine,is a natural pentapeptide isolated from natrue product.It is a good inhibitor of most aspartyl proteases with a K_i in the nanomolar range.
从天然产物中分离得到的Pepstine对大多数天冬氨酸蛋白酶的抑制率达纳摩尔级,但其选择性差、溶解性弱。
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It revealed high inhibition specificity toward serine proteinases (bovine trypsin, bovine chymotrypsin, and porcine trypsin). It did not exert any inhibitory activity toward cystein proteases and aspartyl proteinases.
丝氨酸蛋白酶抑制剂对丝氨酸蛋白酶家族中的牛胰凝乳蛋白酶、牛胰蛋白酶、猪胰蛋白酶三种蛋白酶的活性均有强烈的抑制作用;而对半胱氨酸蛋白酶家族中的木瓜蛋白酶及天冬氨酸蛋白酶家族中的牛胃蛋白酶几乎没有作用。
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aspartyl:门冬氨酰
aryl-芳(香)基 | aspartyl-门冬氨酰 | auri-金(基);(三价)金基
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aspartyl:天[门]冬胺酰基
天[门]冬酰胺酰基 asparaginyl; asparagyl | 天[门]冬胺酰基 aspartyl | 壬二酰基 azelaxyl
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aspartyl hydroxamate:天冬氨酸异羟肟酸
aspartic protease天冬氨酸蛋白酶 | aspartyl hydroxamate天冬氨酸异羟肟酸 | aspergillin曲霉菌素
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aspartyl hydroxamate:天冬氨酸异羥 酸
aspartic protease 天冬氨酸蛋白 | aspartyl hydroxamate 天冬氨酸异羥 酸 | aspergillin 曲霉菌素
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aspartyl phosphate:天冬氨酰磷酸
aspartokinase 天冬氨酸激酶 | aspartyl phosphate 天冬氨酰磷酸 | aspergillic acid 曲霉酸
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