annonaceous [,ænə'neiʃəs]
- annonaceous的基本解释
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adj.
[植]番荔枝科的
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During these years (1997-2000) in the research area of annonaceous acetogenins 5 natural products and a number of chiral-pure analogs of annonaceous acetogenins have been synthesized using sugars as the starting materials. Their high activity and selectivity against cell line of colon tumor and a relationship between activity and configuration have been found too. In the respect of inhibitor of sialidase two new methodologies for the synthesis of chiral-pure 3-deoxy-ulosonic acid using hetero-Diels-Alder reaction or asymmetric propargylation as the key reaction were developed. On the topic of anti-leukemia marine natural product clavulactone a synthetic method based on the free radical cyclization and starting from sugar has been developed. In other title of PKC inhibited agent sphingosine a new synthetic route with SN2' as the key reaction has also been disclosed.
项目期间(1997-2000)在番荔枝内酯方面从糖出发合成了五个天然产物和一批手性纯的类似物,它们对肠癌细胞有很高的活性和选择性,并与构型有关;在唾液酸酶抑制剂方面发展了二类全新手性纯高碳糖的合成方法-杂原子D-A反应或丙炔基不对称加成为关键的反应;抗白血病海洋天然产物群柱虫内酯方面研究了由糖出发和自由基环化反应的合成方法;对PKC 起抑制作用的鞘氨醇方面也开创了新的合成途径-由糖出发并以SN2'反应为关键反应。
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Annonaceous acetogenins are natural compoundsisolated so far only from Annonaceae and showed potential as anticancer,immunosuppressive, and pesticidal agents.
Tonkinecin是一个具C5羟基37个碳的单四氢呋喃环番荔枝内酯化合物,它对人类肿瘤细胞如肝细胞瘤、胃癌等强烈细胞毒性。
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Objective To investigate the effects of annonaceous acetogenin on proliferation and apoptosis in Raji cells and its mechanism.
目的 研究番荔枝内酯对体外人淋巴瘤Raji细胞体外增殖和凋亡的影响及其可能机制。
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Objective To observe the inhibitory action of annonaceous acetogenins AS-4 on human liver cancer cell line HepG2 in vitro.
目的研究番荔枝内酯AS-4在体外对人肝癌细胞株HepG2生长的抑制作用。
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Objective To observe the inhibitory action of annonaceous acetogenins AS-4 on human liver cancer cell line HepG2 in vitro.
目的 研究番荔枝内酯AS-4在体外对人肝癌细胞株HepG2生长的抑制作用。
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annonaceous:番荔枝科的
annomination | 类语重叠 | annonaceous | 番荔枝科的 | annotate | 注释, 评注