abl.

abl.的基本解释

adj.

(=ablative)[语]离格的, 磨蚀的, 可烧蚀的

与abl.相关的网络例句 [注：此内容来源于网络，仅供参考]

CML is cytogenetically marked by the philadelphia chromosome, which originates from a reciprocal translocation between chromosome 9 and 22 and is molecularly marked a chimeric bcr-abl gene, resulting from juxta-positive of the abl proto-oncogene on chromosome 9 with the bcr gene, which is normally located on chromosome 22. The chimeric bcr-abl gene expression an 8. 5kb hybrid mRNA transcript giving rise to a 210-KD fusion protein (P210〓) with increased tyrosine kinase activity. P210〓 plays a key role in the pathogenesis of CML. The continuous cell line K562 was established from the pleural effusion of a 53-year-old female with CML in terminal blast crisis, and was a human erythroleukemia line, contained Ph chromosome.

绝大多数慢粒患者白血病细胞中具有Ph染色体，是由9号染色体长臂3区4带和22号染色体长臂1区1带相互易位形成，即t（9；22），使位于9q〓的c-abl原癌基因在第二外显子的5'端断裂并易位到22 q〓的M-bcr基因第2或第3外显子的3'端，形成异常的bcr-abl嵌合基因，该基因转导出异常的mRNA，编码并翻译出P210蛋白，该蛋白具有很强的酪氨酸激酶活性，使粒细胞发生恶性增殖。K562细胞属于慢粒急变、红白血病细胞株，具有Ph染色体。

P210bcr/abl plays a central role in the pathophysiology of CML. The purpose of this study was to construct a cell line model that bcr/abl expression can be regulated by Tetoff inducingexpressionsystem. The fulllength b3a2 bcr/abl cDNA was subcloned into the pTRE2hyg expression vector to construct the pT2P210 plasmid.

CML是目前致病分子信号基础研究最为清楚的肿瘤之一，1960年Nowell和Hungerford在CML患者的白血病细胞中发现Ph染色体［1］，1973年Rowley等［2］进一步应用染色体分带技术证明，Ph染色体是由9q34的abl基因和22q11 的 bcr 基因相互易位形成的 bcr/abl 融合基因。

"This is an important point," Dr. Sawyers told Medscape in an interview,"as it shows that the drug target continues to mutate and that BCR-ABL is the escape mechanism." Hence, further drug development should continue to focus on BCR-ABL and not on any of the other mechanisms that are thought to also be involved, he commented.

Sawyers医师在一项访谈中向Medscape表示，这是个重点，当这项研究显示药物的标的持续在突变，且BCR-ABL基因有逃脱机转，他评论，之后的药物研发应该继续针对BCR-ABL且不应针对其他被认为牵涉其中的机转。

与abl.相关的网络解释 [注：此内容来源于网络，仅供参考]

abl. ablative：从格

abl. ablative 从格 | acc. accusative 受格 | adv. adverb 副词

abl. ablative：從格,奪格

A. a tmanepada, middle voice 為己 | Abl. ablative 從格,奪格 | abs. absolutive 連續體

BRT. ABL. TH：调节亮度ABL起始点

RGB. TEMP RGB色温 0 0 | BRT. ABL. TH 调节亮度ABL���始点 0 0 | 6 BY. DC. LVL B-Y信号直流电平调节 8 8

BRT. ABL. D：亮度ABL开关

BLK. STK. NG 黑电平增益 1 1 | BRT. ABL. D 亮度ABL���关 0 0 | MID. STD. D ABL���制幅度开关 0 0

MID. STD. D ABL：控制幅度开关

BRT. ABL. D 亮度ABL���关 0 0 | MID. STD. D ABL���制幅度开关 0 0 | RGB. TEMP RGB色温 0 0