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Methods According to the 4×4 Latin Square design,lytic efficacy was assessed in UK dose[(10 000 U/ml,20 000 U/ml,30 000 U/ml or 40 000 U/ml)]and the timing of Uk infusion(2,4,8,16 h after blood sample taken)and UK lytic time(2,4,8,16 h after UK infusion)in vitro.15 rabbits were subjected to the intracerebral hematoma model for analysing the effect of 2 differents UK dose(10 000 U vs 30 000 U)on brain tissue around hematoma cavity.
目的 探讨尿激酶溶解血凝块的最佳用药剂量、用药时机及药物最佳作用时间，为临床一次性清除血肿提供实验依据。方法采用2个(4×4)拉丁方设计，分析UK剂量[(1万U/ml、2万U/ml、3万U/ml、4万U/ml)]、用药时机(抽血后2、4、8、16 h)和药物作用时间(加UK后2、4、8、16 h)对溶凝效果的影响。
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We coupled the IgG of monoclonal antibody N34 specific to UK and the Fab of monoclonal antibody SZ-51 specific to the membrane protein GMP-140 of activated platelet. The bispecific antibody (N34 SZ-51) is able to bind UK and plasma-clot simutaneously. It enhanced plasma clot lysis 5 fold by HUK whereas it enhanced plasma clot lysis 38 times by LUK. UK in association with the bispecific antibody didn't decrease the concentration of fibrinogen in the assay supernatants.
利用抗体介导使纤溶酶原激活剂定向到血栓表面，可大大提高其纤溶作用，我们用双功能团试剂将抗尿激酶的单克隆抗体N34的IgG和抗活化血小板膜蛋白GMP-l40的单抗SZ-5l的Fab片段通过二硫键共价偶联，合成的双专一性抗体（N34-SZ-51）既具有血栓亲和性也具有尿激酶亲和性，从而增加了尿激酶对血栓的专一性，使高分子量尿激酶溶栓率提高了5倍，使低分子量尿激酶溶栓率提高了38倍之多，且不影响血浆中纤维蛋白原的含量。
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UK：英国
Cashfiesta给出了许多Offer 供你注册,由于没有有效的美国信用卡号,有的需要信用卡号的(Credit card required)无法注册,但其中也有能成功注册的,英国(UK) 英国 (UK)>伦敦(London)London,
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UK：联合王国
但是增长率仍低于诸如国内生产总值(GDP)和贸易等其他经济指标的增长率. 尽管如此,研究与开发(R&D)的支出与专利申请量密切相关. R&D方面投资大的国家,其每一居民专利申请量往往更高,美国、日本、中国、德国、法国、联合王国(UK)和韩国的情况就是如此.
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UK：尿激酶
5,溶栓治疗 1) 尿激酶(UK)2万IU/kg/2h,或首剂25万IU单位(相当于4000~4400IU/kg)在30分钟内滴注完,继以4000IU/kg/h连续用药12~24小时. 2) 重组组织型纤溶酶原激活剂(rt-PA)根据体重给50-100mg,外周静脉静滴2小时.
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UK：尿钾
我国学者曾在首钢两家幼儿园观察过限盐和限盐补钙的试验,证明限盐时收缩压(SBP)、舒张压(DBP)均下降,尿钠(UNa)、尿钠钾比(UNa/K)降低,尿钾(UK)升高:恢复常规膳食后,SBP、DBP增高,UNa、UNa/K升高,UK降低.
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UK：abbr. urine kinase; 尿激酶
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