Marcks
- Marcks的基本解释
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[人名] 马克斯
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Objective: To observe the contribution of Qingnao drop pilula to the alteration of myristoylated alanine-rich C kinase substrate mRNA expression in acute multi-infarction hippocampus.
中文摘要:目的:观察清脑滴丸对急性脑缺血海马MARCKS mRNA表达变化的影响,探讨其对急性脑缺血损害的调节作用。
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Qingnao drop pilula can alleciate histomorphology lesion of hippocampus when occurring acute multi-infarction, to turn slower MARCKS mRNA expression, may play a neuroprotective effect role through accommodating PKC-MARCKS signal transduction system.
清脑滴丸可以减轻急性脑缺血时海马组织损伤,下调MARCKS mRNA的过高表达,其机制可能是通过调节PKC-MARCKS信号转导系统而起到神经保护作用。
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Experiment conclusions ①The expression and activation of MARCKS and p-MARCKS were elevated in brain under the condition of acute ischemia, suggesting that over expression of MARCKS transudation pathway might play an important role in brain ischemia.②Treatment with Qingnao Pilular could inhibit the over expression and activation of MARCKS; MARCKS signal transduction pathway could be novel target for the treatment of acute ischemia.
2实验研究结论①在缺血易损区MARCKS及p-MARCKS表达与活化明显增强,提示MARCKS蛋白过表达和活化与脑缺血损害的发生密切相关;②清脑滴丸可以调节脑缺血易损区MARCKS的过表达与活化,MARCKS信号转导通路可能是脑缺血保护治疗的新靶点,为熄风清热、化痰活血法治疗急性缺血性脑血管病提供了一定的理论和实验基础。
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Paul Klee:书本装订工艺
舞台 Schreyer ,Oskar Schlemmer | 书本装订工艺 Paul Klee | 陶艺 Gerhard Marcks
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Walter Gropius ,Mies van der Rohe:建筑
陶艺 Gerhard Marcks | 建筑 Walter Gropius ,Mies van der Rohe | 展示规划 Joost Schmidt