Jun Wang
- Jun Wang的基本解释
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[人名]王军
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- 更多 网络例句 与Jun Wang相关的网络例句 [注:此内容来源于网络,仅供参考]
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Results are as followed:1 Exposure of HELF cells to BP caused c-Jun activation,and increased the activity of MAPK,PI-3K,p53 and cyclin D1 pathway.2 BP-induced c-Jun activation was inhibited by dominant negative mutants of extracellular signal-regulated protein kinase or c-Jun NH_2-terminal kinase,but not by p38,impling that JNK and ERK pathways medicate c-Jun activation induced by BP.3 Overexpression of dominant-negative mutants PI-3K and Akt potently blocked phosphorylations of c-Jun and ERK,but not JNK in response to BP,suggesting that PI-3K/Akt pathway positively regulates BP-induced c-Jun activation through ERK.4 Inhibition of p53 by its chemical or molecular inhibitor markedly increased the phosphorylation levels of c-Jun,Akt and ERK upon BP stimulation,indicating that p53 negatively medicates BP-induced c-Jun activation through PI-3K/Akt/ERK pathway.5 The cell lines expressed TAM67 exhibits no significant affecting normal cell growth properties.6 TAM67 was able to significantly block G_1-S transition and subsequent cell proliferation,suggesting that c-Jun is essential for cell cycle alternations elicited by BP.7 Overexpression of TAM67 impaired BP-induced cyclin D1 activation,decreasing expression of E2F1 and pRb,indicating that c-Jun participates in the modulation of BP-induced activation of cyclin D1/pRb/E2F1 pathway.8 Stably expression of TAM67 led to the increases in the expression levels of p53 and p21,elevating phosphorylation level of p53,clearly indicating that c-Jun regulates p53/p21 pathway activation induced by BRCollectively,PI3K/Akt/ERK pathway mediated BP-induced c-Jun activation through p53-dependent mechanism.
结果显示:1BP刺激细胞可促进c-Jun活化,并伴随着MAPK、PI-3K、p53和cyclinD1通路各组成成分的活性增强。2利用MAPK通路的显性失活突变体分别阻断细胞外信号调节激酶和c-Jun氨基末端激酶活性,均可明显抑制BP诱导的c-Jun活化,但阻断p38活性对BP引起的c-Jun活化无明显影响,提示JNK和ERK通路参与调控BP诱导的c-Jun活化。3过表达PI-3K和Akt的显性失活突变体也可显著抑制BP诱导的c-Jun活化,并降低磷酸化ERK的表达水平,但对磷酸化JNK的表达水平无明显影响,说明PI-3K/Akt通路通过ERK正性调控了BP诱导的c-Jun活化。4p53的化学/分子抑制剂能使BP作用的细胞内c-Jun活性明显增加,并同时诱导Akt和ERK的磷酸化水平的升高,表明p53可通过PI-3K/Akt/ERK通路对BP诱导的c-Jun活化进行负性调控。5随后观察转染细胞的生长情况,发现TAM67对细胞正常生长和形态无明显影响。6稳定表达TAM67可有效抑制BP诱导的S期细胞数的增加,提示c-Jun在BP致细胞周期改变的过程中发挥了重要作用。7TAM67过表达能够抑制BP诱导的cyclin D1活化,降低磷酸化Rb以及E2F1蛋白表达水平,表明c-Jun参与调控BP诱导的cyclin D1/Rb/E2F1通路的活化。8过表达TAM67可使BP刺激的细胞中p53、p21总蛋白以及p53磷酸化的表达水平明显升高,可见c-Jun也参与调控BP诱导的p53/p21通路活化。
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They are the Tang firewood Jun, Song firewood Jun as breasts, Yuan and Ming dynasties of coal Transitional Jun Porcelain, Charcoal-Broiled Qing Jun, and the contemporary straight Yan Jun, and down draft Jun, and Jun Porcelain-free sagger, Coal burning Drawer Jun, and gas mixture burning Jun, natural gas Jun Porcelain.
它们分别是唐代柴烧钧窑、宋代双乳状柴烧钧窑、元明时期柴煤过渡时期钧窑、清代炭烧钧窑、当代直焰钧窑、倒焰钧窑、无匣钵钧窑、煤烧抽屉式钧窑、煤气混合烧钧窑、天然气钧窑。
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Not only but Wang Xinling astonishing the explosive force which makes one hope for soon detonates the sound production in February 24, including while receives training when Japan training period Wang Xinling the leisure window-shops, not only walks on the road many people for Wang Xinling's this attractive female student stops the footsteps, the Japanese male students who says something to smooth things over to Wang Xinling are countless along the way, such situation also lets Wang Xinling regards as year secret weapon Taiwan returns the phonograph record confidence to increase, in not the booming phonograph record market in the business planning, the propaganda, the manufacture investment great writer, elected in 2003 beginning of the spring for the first time to launch an attack from the very beginning at present, then 'Cinderella's tear' took the beginning by Wang Xinling, had little princessThe outlook, Cinderella's will, the host of the same name hits the song 'Cinderella's tear' is defers to the sound energy which and the individuality the heart insults measures body making, believed that focuses attention on the human in the early spring first wave new human tide must be able to capture according to the Wang Xinling strong strength and the appearance which the dazzling good result.
而王心凌惊人的令人期盼的爆发力不但在 2月24日即将引爆发声,连在日本受训期间王心凌趁受训闲暇去逛街时,不但走在路上许多人为王心凌的这位漂亮的女生所停下脚步,沿途对王心凌搭讪的日本男生更是不计其数,这样的情形也让将王心凌视为年度秘密武器台湾艾回唱片信心大增,更在目前不景气的唱片市场一开始在企划、宣传、制作投入大手笔,选在2003年开春首次出击,便以王心凌『灰姑娘的眼泪』作为开场,拥有小公主的外型,灰姑娘的毅力,同名主打歌『灰姑娘的眼泪』便是依照心凌的声音能量与个性所量身打造,相信依照王心凌坚强的实力和受人瞩目的外貌在新春的第一波新人潮中必能夺得耀眼的好成绩。您觉得最佳答案好不好?目前有0人评价
- 更多网络解释 与Jun Wang相关的网络解释 [注:此内容来源于网络,仅供参考]
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JUN AVIGNON:(阿维农) STRASBOURG(斯特拉斯堡)
20 JUN NIMES(尼姆) AVIGNON(阿维农) | 21 JUN AVIGNON(阿维农) STRASBOURG(斯特拉斯堡) | 22 JUN STRASBOURG(斯特拉斯堡) ANNECY(安锡)
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Jun. 11:仁布--年木 (50公里)
Jun. 10 尼木--仁布 (45公里) | Jun. 11 仁布--年木 (50公里) | Jun. 12 年木--日喀则 (50公里)
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Jun. 17:山口--定日 (30公里)
Jun. 16 拉孜--山口 (45公里) | Jun. 17 山口--定日 (30公里) | Jun. 18 定日--扎西宗 (65公里)